Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish
Animals, 2022 In teleost, as in other vertebrates, stress affects reproduction. A key component of the stress response is the pituitary secretion of the adrenocorticotropic hormone (ACTH), which binds to the melanocortin 2 receptor (MC2R) in the adrenal glands and ...
Sandra Navarro +6 more
doaj +1 more source
The melanocortin receptors and their accessory proteins. [PDF]
, 2013 The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Chan, LF +3 more
core +2 more sources
Heparanase affects food intake and regulates energy balance in mice. [PDF]
PLoS ONE, 2012 Mutation of the melanocortin-receptor 4 (MC4R) is the most frequent cause of severe obesity in humans. Binding of agouti-related peptide (AgRP) to MC4R involves the co-receptor syndecan-3, a heparan sulfate proteoglycan.
Linda Karlsson-Lindahl +12 more
doaj +1 more source
Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]
, 2019 The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Biebermann, Heike +10 more
core +1 more source
Genetic obesity: an update with emerging therapeutic approaches [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2022 Based on the genetic contribution, childhood obesity can be classified into 3 groups: common polygenic obesity, syndromic obesity, and monogenic obesity.
Young Bae Sohn
doaj +1 more source
Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function. [PDF]
, 2019 The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Chen, Jihuan +9 more
core +1 more source
Physiopathological Implications of 7TM Receptors [PDF]
, 2010 Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core +1 more source
The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism [PDF]
, 2015 The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer ...
Arble, Deanna M. +10 more
core +2 more sources
Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor [PDF]
, 2007 More than 70 missense mutations have been identified in the human melanocortin 4 receptor (MC4R), and many of them have been associated with obesity. In a number of cases, the causal link between mutations in MC4R and obesity is controversially discussed.
Annette Grüters +34 more
core +1 more source
Melanocortin‐3 receptors are involved in adaptation to restricted feeding [PDF]
Genes, Brain and Behavior, 2012 The central nervous melanocortin system forms a neural network that maintains energy homeostasis. Actions involving neural melanocortin‐3 receptors (MC3Rs) regulate the expression rhythms in ingestive behaviors and metabolism anticipating nutrient intake.
Begriche, K +6 more
openaire +2 more sources