Results 51 to 60 of about 58,672 (263)

Interaction of central kisspeptin with melanocortin, GABAergic, corticotrophin, and NPY systems on food intake in chickens [PDF]

The Iranian Journal of Veterinary Science and Technology, 2022
Kisspeptin is a key component of reproduction that can directly affect food intake in mammals. There is evidence suggesting that melanocortin, GABA, corticotrophin, and neuropeptide Y (NPY), have a mediatory role in reward; however, how these substances ...
Ahmadreza Kord, Bita Vazir, Morteza Zendedel kheybari, Vahab Babapour, Ahmad Asghari   +4 more
doaj   +1 more source

Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia [PDF]

, 2014
Open Access funded by Medical Research CouncilPeer reviewedPublisher ...
Alastair S. Garfield, Blevins, Fisas, Frassetto, Garfield, Grill, Heal, Heisler, Heisler, Heisler, Hirst, Holenz, Jill Shaw, Lam, Lam, Leibowitz, Li, Lora K. Heisler, Luke K. Burke, Mark L. Evans, Michaud, Monti, Roberts, Wesołowska, Woolley, Woolley, Xu, Xu, Yeo   +28 more
core   +1 more source

Endocrinologic Control of Men's Sexual Desire and Arousal/Erection [PDF]

, 2016
Several hormones and neurotransmitters orchestrate men's sexual response, including the appetitive (sexual desire) and consummative (arousal and penile erection) phases.
Aversa, Antonio, Burnett, Arthur L., Corona, Giovanni, Isidori, Andrea, Maggi, Mario   +4 more
core   +1 more source

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. [PDF]

, 2018
Most monogenic cases of obesity in humans have been linked to mutations in genes encoding members of the leptin-melanocortin pathway. Specifically, mutations in MC4R, the melanocortin-4 receptor gene, account for 3-5% of all severe obesity cases in ...
A Hinney, A Marley, A Shalata, Aaron Marley, Adelaide A. Bernard, AS Garfield, BA Ersoy, Baran A. Ersoy, C Lubrano-Berthelier, C Lubrano-Berthelier, C Vaisse, C Vaisse, C Vaisse, Christian Vaisse, D Huszar, E Stergiakouli, F Hildebrandt, GA Bishop, GJ Morton, H Fenselau, JA Green, Jacqueline E. Siljee, Jeremy F. Reiter, JF Reiter, JR Davenport, KC Corbit, L Wu, M Calton, Mark Von Zastrow, MJ Krashes, N Balthasar, NF Berbari, P Aanstad, P Acs, SC Goetz, Sumei Zhang, Y Bromberg, Yi Wang, Z Wang   +38 more
core   +1 more source

Sporadic mutations in melanocortin receptor 3 in morbid obese individuals [PDF]

European Journal of Human Genetics, 2008
Several mutations in the melanocortin receptor 4 gene have been identified in humans and account for 3-6% of morbid obesity. In contrast, strong evidence of a causative role for melanocortin receptor 3 (MC3R) mutations are still lacking. In MC3R knockout mice, high feed efficiency rather than hyperphagia seems to contribute to increased fat mass.
Mencarelli M, Walker GE, Maestrini S, Alberti L, Verti B, Brunani A, PETRONI M, Tagliaferri M, Liuzzi A, Di Blasio AM   +9 more
openaire   +3 more sources

NDP-MSH activates melanocortin-3 receptor to attenuate oxidative stress and neuronal apoptosis in mice with intracerebral hemorrhage via PKC/ERK signaling pathway

Di-san junyi daxue xuebao, 2020
Objective To investigate the inhibitory effect of Nle4-D-Phe7-α-MSH (NDP-MSH) that binds to melanocortin-3 receptor (Mc3r) on oxidative stress and neuronal apoptosis in mice with intracerebral hemorrhage (ICH).
FU Siming, WU Xuan, XIE Zongy
doaj   +1 more source

Melanogenic effect of dersimelagon (MT‐7117), a novel oral melanocortin 1 receptor agonist

Skin Health and Disease, 2022
Background The activation of melanocortin 1 receptor (MC1R) on melanocytes stimulates the production of eumelanin. A tridecapeptide α melanocyte‐stimulating hormone (αMSH) is known to induce skin pigmentation.
T. Suzuki, Y. Kawano, A. Matsumoto, M. Kondo, K. Funayama, S. Tanemura, M. Miyashiro, A. Nishi, K. Yamada, M. Tsuda, A. Sato, K. Morokuma, Y. Yamamoto   +12 more
doaj   +1 more source

Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]

, 2006
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Acuna-Goycolea, Balthasar, Bays, Bednarek, Bonilla, Burdakov, Butler, Choudhury, Cone, Cowley, Cowley, Dhillon, Erickson, Fan, Farooqi, Fekete, Graham, Gropp, Hagan, Harrold, Haskell-Luevano, Hille, Huszar, Ibrahim, Kanjhan, Kas, Kim, Kim, Lechan, Liu, Liu, Mountjoy, Nijenhuis, Plum, Ramos, Roseberry, Srinivasan, Takano, Tang, Wang, Wikberg, Yang   +41 more
core   +4 more sources

CRF1/CRF2 and MC3/MC4 Receptors Affect Glutamate- Induced Food Intake in Neonatal Meat-Type Chicken

Brazilian Journal of Poultry Science, 2019
Central glutamate, melanocortin and corticotropin systems have mediatory role on several physiologic functions in the brain, but their interactions on appetite regulation are not fully elicited.
F Ahmadi, M Zendehdel, V Babapour, N Panahi   +3 more
doaj   +1 more source

Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms. [PDF]

PLoS ONE, 2014
We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose ...
Christopher J Lelliott, Andrea Ahnmark, Therese Admyre, Ingela Ahlstedt, Lorraine Irving, Feenagh Keyes, Laurel Patterson, Michael B Mumphrey, Mikael Bjursell, Tracy Gorman, Mohammad Bohlooly-Y, Andrew Buchanan, Paula Harrison, Tristan Vaughan, Hans-Rudolf Berthoud, Daniel Lindén   +15 more
doaj   +1 more source