Results 71 to 80 of about 59,513 (188)

Funktionelle Konsequenzen von Mutationen im Melanocortin-4-Rezeptorgen bei adipösen Kindern und Jugendlichen [PDF]

, 2006
Der Melanocortin-4-Rezeptor spielt eine zentrale Rolle in der Gewichtsregulation, er vermittelt (indirekt) die anorexigenen Effekte des Leptin, indem er nach Aktivierung eine Einstellung der Nahrungsaufnahme und eine Erhöhung der Stoffwechselrate ...
Gudermann, Thomas (Prof. Dr.), Hohmann, Sarah Hortense   +1 more
core   +1 more source

Genetic Pigmentary Disorders: From Molecular Mechanisms to Clinical Manifestations

The Journal of Dermatology, Volume 53, Issue 2, Page 169-179, February 2026.
ABSTRACT Genetic pigmentary disorders represent a diverse group of genetic conditions characterized by alterations in melanin production and transport and melanocyte development, resulting from single‐gene pathological variants. These disorders encompass both hypopigmentary and hyperpigmentary phenotypes, affecting not only skin pigmentation but also ...
Ken Okamura, Tamio Suzuki
wiley   +1 more source

From Permits to Samples: Addressing Key Challenges for High‐Quality Reference Genome Generation in Europe

Molecular Ecology Resources, Volume 26, Issue 2, February 2026.
ABSTRACT High‐quality reference genome assemblies have become essential for deepening our understanding of biodiversity, yet obtaining them for many species remains surprisingly challenging. Drawing on experiences from the European Reference Genome Atlas (ERGA) community, we focus on permit and sample‐handling procedures leading up to nucleic acid ...
Katja Reichel, Jaakko Pohjoismäki, Jonas J. Astrin, Astrid Böhne, Chiara Bortoluzzi, Elena Bužan, Javier del Campo, Claudio Ciofi, Camilla B. Di‐Nizo, Pradeep K. Divakar, Carola Greve, Vladimír Hampl, Leon Hilgers, Veronika N. Laine, Jennifer A. Leonard, Jesus Lozano‐Fernandez, Lada Lukić Bilela, Camila J. Mazzoni, Ann M. McCartney, José Melo‐Ferreira, Rita Monteiro, Rebekah A. Oomen, Martina Pavlek, João Pimenta, Michal Rindos, Ole Seehausen, Andrii Tarieiev, Salvatore Tomasello, Olga Vinnere Pettersson, Robert M. Waterhouse, Alexandra A.‐T. Weber, Oleksandr Zinenko, Christian de Guttry   +32 more
wiley   +1 more source

Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies. [PDF]

, 2013
Second-generation antipsychotic exposure, in both children and adults, carries significant risk for excessive weight gain that varies widely across individuals.
Aman, MG, Arnold, LE, Handen, B, Johnson, C, Lecavalier, L, McCracken, JT, McDougle, CJ, Nurmi, EL, Posey, DJ, Research Units on Pediatric Psychopharmacology Autism Network, Ritz, L, Scahill, LL, Spilman, SL, Stigler, KA, Sukhodolsky, DG, Tierney, E, Vitiello, B, Whelan, F   +17 more
core   +1 more source

A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors

International Journal of Cosmetic Science, Volume 48, Issue 1, Page 1-15, February 2026.
UV‐induced photodamage leads to increased DNA damage and elevated MMP levels, which degrade collagen and contribute to wrinkle formation. SLT‐001 and SLT‐008, novel cosmetic ingredients that target salt‐inducible kinase, help reverse this effect by enhancing DNA repair, reducing MMP expression and decreasing erythema, thereby mitigating photodamage ...
Inbal Rachmin, Béatrice Le Varlet, Claire Regazzetti, Thierry Passeron, Jinhua Wang, David E. Fisher, Philippe Schaison, Braham Shroot   +7 more
wiley   +1 more source

Palmitate‐induced impairment of melanocortin‐4 receptor

The FASEB Journal, 2013
Obese patients, and diet induced obese rodents, exhibit elevated palmitate in the blood stream and hypothalamus. Elevated palmitate has been found to attenuate hypothalamic insulin signaling, and this effect is thought to be mediated through endoplasmic reticulum (ER) stress.
Faith Kennedy McDaniel, Giulia Baldini
openaire   +1 more source

Cortisol Regulates PD‐1 and IL‐12 in Canine Leishmaniasis

Parasite Immunology, Volume 48, Issue 2, February 2026.
ABSTRACT Canine visceral leishmaniasis (CanL) is a tropical zoonosis caused by Brazil's protozoan Leishmania (L.) infantum. Disorders in the hypothalamic–pituitary–adrenal (HPA) axis have been reported in human and experimental visceral leishmaniasis, but not yet in canine leishmaniasis.
Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Mayla Abbas Guimarães, Bianca Maciel Marques de Souza, Sofia Furrier Soares, Luiz Eduardo Amador Loiola Pereira, Valéria Marçal Felix de Lima   +6 more
wiley   +1 more source

Activation of melanocortin receptors MC1 and MC5 attenuates retinal damage in experimental diabetic retinopathy [PDF]

, 2016
We hypothesize that melanocortin receptors (MC) could activate tissue protective circuit in a model of streptozotocin- (STZ-) induced diabetic retinopathy (DR) in mice.
D'Amico, M., D'Amico, M., Di Filippo, C., Di Filippo, C., Ferraraccio, F., Ferraraccio, F., Gesualdo, C., Gesualdo, C., Getting, S.J., Getting, S.J., Grieco, P., Grieco, P., Kaneva, M.K., Kaneva, M.K., Maisto, R., Maisto, R., Merlino, F., Merlino, F., Perretti, M., Perretti, M., Rossi, S., Rossi, S., Simonelli, F., Simonelli, F., Surace, E., Surace, E., Testa, F., Testa, F., Trotta, M.C., Trotta, M.C.   +29 more
core   +4 more sources

Biochemical and Physiological Effects of Galanin in Health and Disease

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles, Yubo Wang, Kathryn Rhodes, Sharon DeMorrow   +3 more
wiley   +1 more source

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist

New England Journal of Medicine, 2016
Patients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme early-onset obesity, hyperphagia, hypopigmentation, and hypocortisolism, resulting from the lack of the proopiomelanocortin-derived peptides melanocyte-stimulating hormone and corticotropin. In such patients, adrenal insufficiency must be treated with hydrocortisone
Peter, Kühnen, Karine, Clément, Susanna, Wiegand, Oliver, Blankenstein, Keith, Gottesdiener, Lea L, Martini, Knut, Mai, Ulrike, Blume-Peytavi, Annette, Grüters, Heiko, Krude   +9 more
openaire   +2 more sources