Results 191 to 200 of about 49,162 (239)

Characterization of Melanocortin Receptors

Current Protocols in Pharmacology, 2003
AbstractThis unit describes a Scintillation Proximity Assay (SPA) for the measurement of ligand binding to melanocortin receptors (MCRs) using membranes prepared from cell lines stably expressing recombinant MCRs. It provides a facile method for determining the affinity of compounds at MC1R, MC3R, MC4R, or MC5R.
Aaron S, Goetz, Diane M, Ignar
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New ligands for melanocortin receptors

International Journal of Obesity, 2008
Named originally for their effects on peripheral end organs, the melanocortin system controls a diverse set of physiological processes through a series of five G-protein-coupled receptors and several sets of small peptide ligands. The central melanocortin system plays an essential role in homeostatic regulation of body weight, in which two alternative ...
C B, Kaelin, S I, Candille, B, Yu, P, Jackson, D A, Thompson, M A, Nix, J, Binkley, G L, Millhauser, G S, Barsh   +8 more
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Melanocortin Receptors and Erectile Function

European Urology, 2004
Review the historical and current evidence that suggests that activation of melanocortin receptors modulates erectile activity.The available literature was reviewed.Melanocortin peptides derived from the pro-opiomelanocortin (POMC) precursor protein exert a host of diverse physiological effects in the periphery and in the CNS through interactions with ...
William J, Martin, D Euan, MacIntyre
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Melanocortin-5 receptor and sebogenesis

European Journal of Pharmacology, 2011
The melanocortins (α-MSH, β-MSH, γ-MSH, and ACTH) bind to the melanocortin receptors and signal through increases in cyclic adenosine monophosphate to induce biological effects. The melanocortin MC(5) and MC(1) receptors are expressed in human sebaceous glands, which produce sebum, a lipid mixture of squalene, wax esters, triglycerides, cholesterol ...
Li, Zhang, Wen-Hwa, Li, Michael, Anthonavage, Apostolos, Pappas, Dianne, Rossetti, Druie, Cavender, Miri, Seiberg, Magdalena, Eisinger   +7 more
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Evolution of melanocortin receptors in teleost fish: The melanocortin type 1 receptor

Gene, 2007
The melanocortin type 1 receptor (Mc1r) belongs to a family of G-protein-coupled receptors involved in various physiological processes in vertebrates. Melanocortins, the Mcr natural agonists, are pituitary peptide hormones including adrenocorticotropin and melanocyte-stimulating hormones.
Yvonne, Selz, Ingo, Braasch, Carsten, Hoffmann, Cornelia, Schmidt, Christina, Schultheis, Manfred, Schartl, Jean-Nicolas, Volff   +6 more
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Molecular Modeling of Melanocortin Receptors

Current Topics in Medicinal Chemistry, 2007
Molecular modeling of G-protein coupled receptors (GPCRs) remains a challenge due to the limited availability of structural information for the receptors. Molecular modeling approaches for melanocortin receptors (MCRs) fall into three categories: structure-based, ligand-based, and proteochemometric.
Hongmao, Sun, David, Fry
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Melanocortin receptors weigh in

Nature Medicine, 2004
Well over ten years ago, hints begin to emerge that the melanocortin system, implicated in adrenal function and skin pigmentation, might also regulate energy balance. In the 1990s, speculation gave way to hard data: a melanocortin receptor highly expressed in the brain was firmly established as a central regulator of food intake and fat mass.
Stephen O'Rahilly, Giles S H Yeo, I Sadaf Farooqi   +2 more
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The Melanocortin Receptors

2000
Part I: Historical Perspectives. Proopiomelanocortin and the Melanocortin Peptides, A. N. Eberle. Melanocortins and Pigmentation, A. B. Lerner. Melanocortins and Adrenocortical Function, M. Begeot and J. M. Saez. Effects of Melanocortins in the Nervous System, R. A. H. Adan. Peripheral Effects of Melanocortins, B. A. Boston. Part II.
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Melanocortin 3 receptor gene and melanocortin 4 receptor gene mutations: the Asian Perspective

Diabetes/Metabolism Research and Reviews, 2012
SummaryMelanocortin 4 receptor (MC4R) deficiency resulting from disruption of one or both MC4R alleles represents the commonest monogenic form of human obesity to date. Human MC4R deficiency was reported to affect 4 and 5.8% of severely obese French and British populations respectively.
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Melanocortin Receptors: Ligands and Proteochemometrics Modeling

Annals of the New York Academy of Sciences, 2003
Abstract: The melanocortin receptors exist in five subtypes, MC1–5R. These receptors participate in important regulations of the immune system, central behavior, and endocrine and exocrine glands. Here we provide a short review on MCR subtype selective peptides and organic compounds with activity on the MCRs, developed in our laboratory. Also provided
J E S, Wikberg, F, Mutulis, I, Mutule, S, Veiksina, M, Lapinsh, R, Petrovska, P, Prusis   +6 more
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