Melanocortin 1 Receptor: Structure, Function and Regulation [PDF]
Frontiers in Genetics, 2016 The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic gene, and loss of function correlates with a fair, UV-sensitive, and melanoma ...
Erin Marissa Wolf Horrell +2 more
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Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects. [PDF]
Int J Mol Sci, 2023 Melanocortins play crucial roles in regulating the stress response, inflammation, and skin pigmentation. In this review, we focus on the melanocortin 1 receptor (MC1R), a G protein-coupled receptor primarily known for regulating skin pigmentation and ...
Mun Y, Kim W, Shin D.
europepmc +4 more sources
Melanogenic effect of dersimelagon (MT‐7117), a novel oral melanocortin 1 receptor agonist [PDF]
Skin Health and Disease, 2022 Background The activation of melanocortin 1 receptor (MC1R) on melanocytes stimulates the production of eumelanin. A tridecapeptide α melanocyte‐stimulating hormone (αMSH) is known to induce skin pigmentation.
T. Suzuki +12 more
doaj +3 more sources
Journey through the spectacular landscape of melanocortin 1 receptor. [PDF]
Pigment Cell Melanoma ResThe physiological role of α‐melanocyte stimulating hormone in regulating integumental pigmentation of many vertebrate species has been recognized since the 1960's.
Upadhyay PR +4 more
europepmc +4 more sources
Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground The melanocortin 1 receptor (MC1R) is abundantly expressed in the skin and leukocytes, where it regulates skin pigmentation and inflammatory responses.
Anni Suominen +9 more
doaj +5 more sources
Melanocortin 1 Receptor Targeted Imaging of Melanoma With Gold Nanocages and Positron Emission Tomography [PDF]
Molecular Imaging, 2018 Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable ...
Yongfeng Zhao PhD +8 more
doaj +4 more sources
Effects of melanocortin 1 receptor agonists in experimental nephropathies. [PDF]
PLoS ONE, 2014 Nephrotic syndrome, characterized by massive proteinuria, is caused by a large group of diseases including membranous nephropathy (MN) and focal segmental glomerulosclerosis (FSGS).
Annika Lindskog Jonsson +5 more
doaj +6 more sources
Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages. [PDF]
Circulation, 2017 Background: The melanocortin 1 receptor (MC1-R) is expressed by monocytes and macrophages, where it exerts anti-inflammatory actions on stimulation with its natural ligand α-melanocyte–stimulating hormone. The present study was designed to investigate the specific role of MC1-R in the context of atherosclerosis and possible ...
Rinne P +14 more
europepmc +7 more sources
Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E-/- Mice. [PDF]
Arterioscler Thromb Vasc Biol, 2018 Objective— The MC1-R (melanocortin 1 receptor) is expressed by monocytes and macrophages where it mediates anti-inflammatory actions. MC1-R also protects against macrophage foam cell formation primarily by promoting cholesterol efflux through the ABCA1 ...
Rinne P +8 more
europepmc +7 more sources
Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity. [PDF]
Nat Commun, 2023 Inhibition of T cell infiltration dampens antitumor immunity and causes resistance to immune checkpoint blockade (ICB) therapy. By in vivo CRISPR screening in B16F10 melanoma in female mice, here we report that loss of melanocortin-1 receptor (MC1R) in ...
Cui Y +8 more
europepmc +2 more sources