Results 31 to 40 of about 994,457 (252)

Selection on the Major Color Gene Melanocortin-1-Receptor Shaped the Evolution of the Melanocortin System Genes. [PDF]

International Journal of Molecular Sciences, 2017
Modular genetic systems and networks have complex evolutionary histories shaped by selection acting on single genes as well as on their integrated function within the network. However, uncovering molecular coevolution requires the detection of coevolving
Alexandre Roulin, Anne-Lyse Ducrest, Fisher, Linda Dib, Luis San-Jose, Nicolas Salamin, Quinn, Salzet   +7 more
core   +3 more sources

Probing the Role of Melanocortin Type 1 Receptor Agonists in Diverse Immunological Diseases

Frontiers in Pharmacology, 2019
Background: The melanocortin α-melanocyte stimulating hormone (α-MSH), an endogenous peptide with high affinity for the melanocortin 1 receptor (MC1r), has demonstrated prevention and reversal of intestinal and ocular inflammation in animal models ...
Carl Spana, Andrew W. Taylor, David G. Yee, Marie Makhlina, Wei Yang, John Dodd   +5 more
doaj   +2 more sources

Melanoma-associated melanocortin 1 receptor variants confer redox signaling-dependent protection against oxidative DNA damage [PDF]

Redox Biology
Cutaneous melanoma, a lethal skin cancer, arises from malignant transformation of melanocytes. Solar ultraviolet radiation (UVR) is a major environmental risk factor for melanoma since its interaction with the skin generates DNA damage, either directly ...
María Castejón-Griñán, Sonia Cerdido, José Sánchez-Beltrán, Ana Lambertos, Marta Abrisqueta, Cecilia Herraiz, Celia Jiménez-Cervantes, José Carlos García-Borrón   +7 more
doaj   +2 more sources

Dual melanocortin‐4 receptor and GLP‐1 receptor agonism amplifies metabolic benefits in diet‐induced obese mice

EMBO Molecular Medicine, 2015
We assessed the efficacy of simultaneous agonism at the glucagon‐like peptide‐1 receptor (GLP‐1R) and the melanocortin‐4 receptor (MC4R) for the treatment of obesity and diabetes in rodents.
Christoffer Clemmensen, Brian Finan, Katrin Fischer, Robby Zachariah Tom, Beata Legutko, Laura Sehrer, Daniela Heine, Niklas Grassl, Carola W Meyer, Bart Henderson, Susanna M Hofmann, Matthias H Tschöp, Lex HT Van der Ploeg, Timo D Müller   +13 more
doaj   +2 more sources

Fingolimod and Diabetic Retinopathy: A Drug Repurposing Study

Frontiers in Pharmacology, 2021
This study aimed to investigate the interactions between fingolimod, a sphingosine 1-phosphate receptor (S1PR) agonist, and melanocortin receptors 1 and 5 (MCR1, MCR5).
Carlo Gesualdo, Cornel Balta, Chiara Bianca Maria Platania, Maria Consiglia Trotta, Hildegard Herman, Sami Gharbia, Marcel Rosu, Francesco Petrillo, Salvatore Giunta, Alberto Della Corte, Paolo Grieco, Rosa Bellavita, Francesca Simonelli, Michele D’Amico, Anca Hermenean, Anca Hermenean, Settimio Rossi, Claudio Bucolo   +17 more
doaj   +1 more source

The α‐melanocyte‐stimulating hormone/melanocortin‐1 receptor interaction: A driver of pleiotropic effects beyond pigmentation

Pigment Cell & Melanoma Research, 2021
Melanocortin‐1 Receptor (MC1R), when stimulated by alpha‐melanocyte‐stimulating hormone (α‐MSH), is a driver of eumelanogenesis. Brown/black eumelanin is an effective filter against ultraviolet radiation (UVR) and is a scavenger of free radicals. Several
C. Herraiz, Idoya Martínez-Vicente, V. Maresca   +2 more
semanticscholar   +1 more source

The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans. [PDF]

PLoS ONE, 2010
BACKGROUND: The neuropeptide alpha-melanocyte-stimulating hormone is well known as a mediator of skin pigmentation. More recently, it has been shown that alpha-melanocyte-stimulating hormone also plays pivotal roles in energy homeostasis, sexual function,
Karin Loser, Thomas Brzoska, Vinzenz Oji, Matteo Auriemma, Maik Voskort, Verena Kupas, Lars Klenner, Cornelius Mensing, Axel Hauschild, Stefan Beissert, Thomas A Luger   +10 more
doaj   +1 more source

Melanocortin 1 Receptor Agonists Reduce Proteinuria [PDF]

Journal of the American Society of Nephrology, 2010
Membranous nephropathy is one of the most common causes of nephrotic syndrome in adults. Recent reports suggest that treatment with adrenocorticotropic hormone (ACTH) reduces proteinuria, but the mechanism of action is unknown. Here, we identified gene expression of the melanocortin receptor MC1R in podocytes, glomerular endothelial cells, mesangial ...
Annika, Lindskog, Kerstin, Ebefors, Martin E, Johansson, Bergur, Stefánsson, Anna, Granqvist, Margret, Arnadottir, Anna-Lena, Berg, Jenny, Nyström, Börje, Haraldsson   +8 more
openaire   +2 more sources

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

Molecular Metabolism, 2021
Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more ...
Giles S.H. Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M. Koerperich, Mark D. Ericson, Stephanie E. Simonds, Courtney M. Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A. Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger A.H. Adan   +14 more
doaj   +1 more source

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]

, 2020
The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo, Biebermann, Heike, Dimitriou, Ioanna Maria, Krude, Heiko, Kühnen, Peter, Lohse, Martin J., Paisdzior, Sarah, Scheerer, Patrick, Schöpe, Paul Curtis   +8 more
core   +3 more sources