An overview of benefits and risks of chronic melanocortin-1 receptor activation. [PDF]
J Eur Acad Dermatol VenereolThe melanocortin‐1 receptor (MC1R) is a G protein‐coupled receptor that plays a pivotal role in human skin pigmentation, melanin synthesis, redox homeostasis and inflammation. Loss‐of‐function MC1R variants suppress G protein‐coupled receptor coupling or
Böhm M +4 more
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Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats. [PDF]
Theranostics, 2021 Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury (EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of melanocortin 1 receptor (MC1R), using BMS-470539, attenuates EBI by ...
Xu W +7 more
europepmc +2 more sources
Frontiers in Endocrinology, 2016 ACTH acts via a highly selective receptor that is a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors. The ACTH receptor, also known as the melanocortin 2 receptor (MC2R) is unusual in that it is absolutely dependent on ...
Adrian John Clark +6 more
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Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver [PDF]
eLife, 2023 Melanocortin 1 receptor (MC1-R) is widely expressed in melanocytes and leukocytes and is thus strongly implicated in the regulation of skin pigmentation and inflammation.
Keshav Thapa +7 more
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Regulation of Melanocortin-3 and -4 Receptors by Isoforms of Melanocortin-2 Receptor Accessory Protein 1 and 2 [PDF]
Biomolecules, 2022 The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Interaction of neural MCRs and melanocortin-2 receptor accessory proteins (MRAPs, MRAP1
Ren-Lei Ji, Ya-Xiong Tao
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Detecting Melanocortin 1 Receptor Gene's SNPs by CRISPR/enAsCas12a. [PDF]
Genes (Basel), 2023 Beyond its powerful genome-editing capabilities, the CRISPR/Cas system has opened up a new era of molecular diagnostics due to its highly specific base recognition and trans-cleavage activity. However, most CRISPR/Cas detection systems are mainly used to detect nucleic acids of bacteria or viruses, while the application of single nucleotide ...
Yang W, Tao D, Xu B, Zheng Y, Zhao S.
europepmc +3 more sources
Melanocortin 1 Receptor-Targeted α-Particle Therapy for Metastatic Uveal Melanoma. [PDF]
J Nucl Med, 2019 New effective therapies are greatly needed for metastatic uveal melanoma, which has a very poor prognosis with a median survival of less than 1 y. The melanocortin 1 receptor (MC1R) is expressed in 94% of uveal melanoma metastases, and a MC1R-specific ...
Tafreshi NK +20 more
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A novel oral formulation of the melanocortin-1 receptor agonist PL8177 resolves inflammation in preclinical studies of inflammatory bowel disease and is gut restricted in rats, dogs, and humans [PDF]
Frontiers in Immunology, 2023 IntroductionPL8177 is a potent and selective agonist of the melanocortin 1 receptor (MC1R). PL8177 has shown efficacy in reversing intestinal inflammation in a cannulated rat ulcerative colitis model.
John Dodd +8 more
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Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in Xenopus tropicalis [PDF]
Frontiers in Endocrinology, 2022 The melanocortin system consists of five G protein–coupled receptors (MC1R-MC5R), the bidirectional endogenous ligands (MSH and Agouti families), and accessory proteins (MRAP1 and MRAP2).
Xiaolu Tai +8 more
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Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease [PDF]
Molecular Neurodegeneration, 2022 Background Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson’s disease (PD).
Waijiao Cai +10 more
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