Results 21 to 30 of about 994,457 (252)

Malignant melanoma and melanocortin 1 receptor [PDF]

Biochemistry (Moscow), 2013
The conventional chemotherapeutic treatment of malignant melanoma still remains poorly efficient in most cases. Thus the use of specific features of these tumors for development of new therapeutic modalities is highly needed. Melanocortin 1 receptor (MC1R) overexpression on the cell surface of the vast majority of human melanomas, making MC1R a ...
A. A. Rosenkranz, A. A. Rosenkranz, T. A. Slastnikova, M. Durymanov, M. Durymanov, A. S. Sobolev, A. S. Sobolev   +6 more
semanticscholar   +3 more sources

Enhancing the Efficacy of Melanocortin 1 Receptor-Targeted Radiotherapy by Pharmacologically Upregulating the Receptor in Metastatic Melanoma. [PDF]

Mol Pharm, 2019
Melanocortin 1 receptor (MC1R) is under investigation as a target for drug delivery for metastatic melanoma therapy and imaging. The purpose of this study was to determine the potential of using BRAF inhibitors (BRAFi) and histone deacetylase inhibitors (
Li M, Liu D, Lee D, Kapoor S, Gibson-Corley KN, Quinn TP, Sagastume EA, Mott SL, Walsh SA, Acevedo MR, Johnson FL, Schultz MK.   +11 more
europepmc   +2 more sources

Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor. [PDF]

Proc Natl Acad Sci U S A, 2019
Significance This study expands understanding of opsin 3 (OPN3) function and of skin pigmentation. The findings presented here reveal that the nonvisual OPN3 modulates the pigmentation of human epidermal melanocytes—the melanin-producing cells of the ...
Ozdeslik RN, Olinski LE, Trieu MM, Oprian DD, Oancea E.   +4 more
europepmc   +2 more sources

Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao   +2 more
doaj   +3 more sources

Localization of Melanocortin 1 Receptor in the Substantia Nigra. [PDF]

Int J Mol Sci
Recent findings have revealed that melanocortin 1 receptor (MC1R) deficiency leads to Parkinson’s disease-like dopaminergic neurodegeneration in the substantia nigra (SN). However, its precise distribution and expressing-cell type in the SN remain unclear.
Ehara A, Ito N, Nakadate K, Tokuda N.
europepmc   +3 more sources

⁶⁸Ga-DOTA-GGNle-CycMSH_hex targets the melanocortin-1 receptor for melanoma imaging. [PDF]

Sci Transl Med, 2018
68Ga-DOTA-GGNle-CycMSHhex, a radiolabeled melanocortin-1 receptor–targeting imaging probe, detects melanoma in first-in-human testing. Visualizing the target Metastatic melanoma (skin cancer) has a high mortality rate. Yang et al.
Yang J, Xu J, Gonzalez R, Lindner T, Kratochwil C, Miao Y.   +5 more
europepmc   +2 more sources

Molecular Imaging and Radionuclide Therapy of Melanoma Targeting the Melanocortin 1 Receptor

Molecular Imaging, 2017
Melanoma is a deadly disease at late metastatic stage, and early diagnosis and accurate staging remain the key aspects for managing melanoma. The melanocortin 1 receptor (MC1 R) is overexpressed in primary and metastatic melanomas, and its endogenous ...
Chengcheng Zhang PhD, Kuo-Shyan Lin PhD, François Bénard MD   +2 more
doaj   +2 more sources

Amplification of the Melanocortin-1 Receptor in Nephrotic Syndrome Identifies a Target for Podocyte Cytoskeleton Stabilization. [PDF]

Sci Rep, 2018
The melanocortin-1 receptor (MC1R) in podocytes has been suggested as the mediator of the ACTH renoprotective effect in patients with nephrotic syndrome with the mechanism of action beeing stabilization of the podocyte actin cytoskeleton.
Bergwall L, Wallentin H, Elvin J, Liu P, Boi R, Sihlbom C, Hayes K, Wright D, Haraldsson B, Nyström J, Buvall L.   +10 more
europepmc   +2 more sources

Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor. [PDF]

Cell Res, 2021
Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE.   +9 more
europepmc   +2 more sources

Patients with Obesity Caused by Melanocortin-4 Receptor Mutations Can Be Treated with a Glucagon-like Peptide-1 Receptor Agonist.

Cell Metabolism, 2018
Pathogenic mutations in the appetite-regulating melanocortin-4 receptor (MC4R) represent the most common cause of monogenic obesity with limited treatment options.
E. Iepsen, Jinyi Zhang, H. Thomsen, E. Hansen, Mette Hollensted, S. Madsbad, T. Hansen, J. Holst, J. Holm, S. Torekov   +9 more
semanticscholar   +3 more sources