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Chemistry of the Melanocyte-stimulating Hormones
1966The melanocyte stimulating hormones (MSH; intermedin) of the pituitary gland are polypeptides of low molecular weight. Although assays of naturally-occurring and synthetic corticotropins (ACTH) have unequivocally demonstrated that ACTH possesses an intrinsic melanocyte-stimulating activity, most of the melanocyte-stimulating activity found in the whole
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Neuropharmacological tests with α-melanocyte stimulating hormone
Life Sciences, 1976Abstract The pituitary peptide hormone α-MSH was found to potentiate the behavioral effects of DOPA but not serotonin. It slightly reduced footshock-induced fighting and decreased audiogenic seizures in susceptible mice, but was inactive in reducing the tremors induced by oxotremorine.
Nicholas P. Plotnikoff+3 more
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Hormone-Replacement Therapy for Melanocyte-Stimulating Hormone Deficiency
New England Journal of Medicine, 2016The first law of endocrine disease treatment is that an absent hormone should be replaced. As they report in this issue of the Journal, Kuhnen et al.1 successfully applied this principle to two adult patients with genetic proopiomelanocortin deficiency, and both patients had impressive hunger reduction and weight loss as well as improved insulin ...
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THE ADIPOKINETIC ACTIVITIES OF THE CORTICOTROPHINS AND MELANOCYTE STIMULATING HORMONES
Acta Endocrinologica, 1960ABSTRACT Pepsin degraded and non-degraded corticotrophin (ACTH) preparations all are highly adipokinetic and, in general, this parallels ACTH activity. a and β melanocyte stimulating hormones (MSH) are largely devoid of this activity. The structures necessary for fat mobilizing activity are similar but not identical to those for ACTH.
Sanford L. Steelman, William W. Smith
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Melanocyte-stimulating hormone and learned appetitive behavior
Experientia, 1969Cette etude indique que l'administration de α MSH aux rats les fait retenir une tâche appetitive. Un effet sur la perseveration ou la memoire est implique.
Andrew V. Schally+2 more
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Journal of Endocrinology, 1975
Alpha-Melanocyte-stimulating hormone was shown to act synergistically with testosterone to stimulate the sebaceous, prostate and the seminal vesicles in hypophys-ectomized-castrated rats.
F. Ebling+3 more
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Alpha-Melanocyte-stimulating hormone was shown to act synergistically with testosterone to stimulate the sebaceous, prostate and the seminal vesicles in hypophys-ectomized-castrated rats.
F. Ebling+3 more
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Behavioral Aspects of Melanocyte-Stimulating Hormone (MSH)
1973Publisher Summary This chapter explores the behavioral aspects of melanocyte-stimulating hormone (MSH). The pituitary hormone MSH is tested in several different behavioral systems. MSH is a hormone(s) whose presence has persisted in the pituitary gland of vertebrates from very low forms to man.
Andrew V. Schally+5 more
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Control of sebaceous gland function in the rat by alpha-melanocyte-stimulating hormone.
Journal of Endocrinology, 1975The effect of alpha-MSH on sebum secretion and preputial gland weight was examined in intact, castrated and hypophysectomized male rats and in hypophysectomized rats receiving treatment with either testosterone propionate (TP) or progesterone.
A. Thody+7 more
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Effect of Melanocyte-stimulating Hormone on the Eye of the Rabbit
Nature, 1963THE aqueous flare is a scattering phenomenon, which may be observed when a beam of light passes the anterior chamber of the eye. It is caused by the presence of substances with large molecules (proteins). Using a photographic apparatus1 for measuring the intensity of the flare, Anjou, Krakau and Stigmar2 observed that an injection of ...
K. Dyster-Aas, C. E. T. Krakau
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Relationship of melanocyte-stimulating hormone to photoreceptor damage
Peptides, 1980Three separate experiments involving intact, sham-operated and hypophysectomized albino rats, examined the relationship of alpha-MSH to the severity of photically-induced retinal damage. alpha-MSH was administered at 1430 hours and 0900 hours, when endogenous MSH levels are different, and continuously by osmotic minipumps.
Abba J. Kastin+2 more
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