Results 21 to 30 of about 7,637 (207)

α-MSH analogue attenuates blood pressure elevation in DOCA-salt hypertensive mice. [PDF]

PLoS ONE, 2013
Melanocyte-stimulating hormones, α-, β- and γ-MSH, regulate important physiological functions including energy homeostasis, inflammation and sodium metabolism.
Petteri Rinne, Anna-Maija Penttinen, Wendy Nordlund, Markku Ahotupa, Eriika Savontaus   +4 more
doaj   +1 more source

Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice

Molecular Metabolism, 2019
Objective: Life-threatening hypoglycemia is a major limiting factor in the management of diabetes. While it is known that counterregulatory responses to hypoglycemia are impaired in diabetes, molecular mechanisms underlying the reduced responses remain ...
Benjamin P. Tooke, Hui Yu, Jessica M. Adams, Graham L. Jones, Talisha Sutton-Kennedy, Lakshmi Mundada, Nathan R. Qi, Malcolm J. Low, Kavaljit H. Chhabra   +8 more
doaj   +1 more source

D-TRP(8)-γMSH Prevents the Effects of Endotoxin in Rat Skeletal Muscle Cells through TNFα/NF-KB Signalling Pathway. [PDF]

PLoS ONE, 2016
Sepsis induces anorexia and muscle wasting secondary to an increase in muscle proteolysis. Melanocyte stimulating hormones (MSH) is a family of peptides that have potent anti-inflammatory effects.
Ana Belén Gómez-SanMiguel, María Ángeles Villanúa, Ana Isabel Martín, Asunción López-Calderón   +3 more
doaj   +1 more source

Multiple sclerosis, relapses, and the mechanism of action of adrenocorticotropic hormone (ACTH)

Frontiers in Neurology, 2013
Relapses in multiple sclerosis (MS) are disruptive and frequently disabling for patients, and their treatment is often a challenge to clinicians. Despite progress in the understanding of the pathophysiology of MS and development of new treatments for ...
Amy ePerrin Ross, Aliza eBen-Zacharia, Colleen J Harris, Jennifer eSmrtka   +3 more
doaj   +1 more source

The role of proopiomelanocortin (POMC) neurones in feeding behaviour

Nutrition & Metabolism, 2007
The precursor protein, proopiomelanocortin (POMC), produces many biologically active peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and β-endorphin.
Millington George WM
doaj   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Melanocortin Peptide Therapy for the Treatment of Arthritic Pathologies

The Scientific World Journal, 2009
Arthritic pathologies are a major cause of morbidity within the western world, with rheumatoid arthritis affecting approximately 1% of adults. This review highlights the therapeutic potential of naturally occurring hormones and their peptides, in both ...
S. J. Getting, M. Kaneva, Y. Bhadresa, D. Renshaw, Giovanna Leoni, H. B. Patel, M. J. P. Kerrigan, I. C. Locke   +7 more
doaj   +1 more source

Molecular evolution of the proopiomelanocortin system in Barn owl species.

PLoS ONE, 2020
Examination of genetic polymorphisms in outbred wild-living species provides insights into the evolution of complex systems. In higher vertebrates, the proopiomelanocortin (POMC) precursor gives rise to α-, β-, and γ-melanocyte-stimulating hormones (MSH),
Karin Löw, Anne-Lyse Ducrest, Luis M San-Jose, Céline Simon, Vera Uva, Nabil G Seidah, Antonella Pasquato, Stefan Kunz, Alexandre Roulin   +8 more
doaj   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source