Results 21 to 30 of about 5,590 (146)
α-MSH analogue attenuates blood pressure elevation in DOCA-salt hypertensive mice. [PDF]
PLoS ONE, 2013 Melanocyte-stimulating hormones, α-, β- and γ-MSH, regulate important physiological functions including energy homeostasis, inflammation and sodium metabolism.
Petteri Rinne +4 more
doaj +1 more source
Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice
Molecular Metabolism, 2019 Objective: Life-threatening hypoglycemia is a major limiting factor in the management of diabetes. While it is known that counterregulatory responses to hypoglycemia are impaired in diabetes, molecular mechanisms underlying the reduced responses remain ...
Benjamin P. Tooke +8 more
doaj +1 more source
D-TRP(8)-γMSH Prevents the Effects of Endotoxin in Rat Skeletal Muscle Cells through TNFα/NF-KB Signalling Pathway. [PDF]
PLoS ONE, 2016 Sepsis induces anorexia and muscle wasting secondary to an increase in muscle proteolysis. Melanocyte stimulating hormones (MSH) is a family of peptides that have potent anti-inflammatory effects.
Ana Belén Gómez-SanMiguel +3 more
doaj +1 more source
Multiple sclerosis, relapses, and the mechanism of action of adrenocorticotropic hormone (ACTH)
Frontiers in Neurology, 2013 Relapses in multiple sclerosis (MS) are disruptive and frequently disabling for patients, and their treatment is often a challenge to clinicians. Despite progress in the understanding of the pathophysiology of MS and development of new treatments for ...
Amy ePerrin Ross +3 more
doaj +1 more source
The role of proopiomelanocortin (POMC) neurones in feeding behaviour
Nutrition & Metabolism, 2007 The precursor protein, proopiomelanocortin (POMC), produces many biologically active peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and β-endorphin.
Millington George WM
doaj +1 more source
Melanocortin Peptide Therapy for the Treatment of Arthritic Pathologies
The Scientific World Journal, 2009 Arthritic pathologies are a major cause of morbidity within the western world, with rheumatoid arthritis affecting approximately 1% of adults. This review highlights the therapeutic potential of naturally occurring hormones and their peptides, in both ...
S. J. Getting +7 more
doaj +1 more source
Molecular evolution of the proopiomelanocortin system in Barn owl species.
PLoS ONE, 2020 Examination of genetic polymorphisms in outbred wild-living species provides insights into the evolution of complex systems. In higher vertebrates, the proopiomelanocortin (POMC) precursor gives rise to α-, β-, and γ-melanocyte-stimulating hormones (MSH),
Karin Löw +8 more
doaj +1 more source
Frontiers in Endocrinology, 2013 Proopiomelanocortin (POMC) is the precursor of several peptide hormones generated in the pituitary gland. After biosynthesis, POMC undergoes several posttranslational modifications, including proteolytic cleavage, acetylation, amidation, phosphorylation,
Akiyoshi eTakahashi, Kanta eMizusawa
doaj +1 more source
Frontiers in Endocrinology, 2019 The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Nicolas Heyder +10 more
doaj +1 more source
Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2009 The authors carried on the research of the activity pituitary-gonadal system unter stress thermic on white rats. There were established that stress termic reduses consentration of sexual hormones but administration of the melanocyte stimulating hormone ...
USM ADMIN
doaj