Results 31 to 40 of about 5,735 (191)

α-MSH analogue attenuates blood pressure elevation in DOCA-salt hypertensive mice. [PDF]

PLoS ONE, 2013
Melanocyte-stimulating hormones, α-, β- and γ-MSH, regulate important physiological functions including energy homeostasis, inflammation and sodium metabolism.
Petteri Rinne, Anna-Maija Penttinen, Wendy Nordlund, Markku Ahotupa, Eriika Savontaus   +4 more
doaj   +1 more source

Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice

Molecular Metabolism, 2019
Objective: Life-threatening hypoglycemia is a major limiting factor in the management of diabetes. While it is known that counterregulatory responses to hypoglycemia are impaired in diabetes, molecular mechanisms underlying the reduced responses remain ...
Benjamin P. Tooke, Hui Yu, Jessica M. Adams, Graham L. Jones, Talisha Sutton-Kennedy, Lakshmi Mundada, Nathan R. Qi, Malcolm J. Low, Kavaljit H. Chhabra   +8 more
doaj   +1 more source

D-TRP(8)-γMSH Prevents the Effects of Endotoxin in Rat Skeletal Muscle Cells through TNFα/NF-KB Signalling Pathway. [PDF]

PLoS ONE, 2016
Sepsis induces anorexia and muscle wasting secondary to an increase in muscle proteolysis. Melanocyte stimulating hormones (MSH) is a family of peptides that have potent anti-inflammatory effects.
Ana Belén Gómez-SanMiguel, María Ángeles Villanúa, Ana Isabel Martín, Asunción López-Calderón   +3 more
doaj   +1 more source

Multiple sclerosis, relapses, and the mechanism of action of adrenocorticotropic hormone (ACTH)

Frontiers in Neurology, 2013
Relapses in multiple sclerosis (MS) are disruptive and frequently disabling for patients, and their treatment is often a challenge to clinicians. Despite progress in the understanding of the pathophysiology of MS and development of new treatments for ...
Amy ePerrin Ross, Aliza eBen-Zacharia, Colleen J Harris, Jennifer eSmrtka   +3 more
doaj   +1 more source

The role of proopiomelanocortin (POMC) neurones in feeding behaviour

Nutrition & Metabolism, 2007
The precursor protein, proopiomelanocortin (POMC), produces many biologically active peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and β-endorphin.
Millington George WM
doaj   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Melanocortin Peptide Therapy for the Treatment of Arthritic Pathologies

The Scientific World Journal, 2009
Arthritic pathologies are a major cause of morbidity within the western world, with rheumatoid arthritis affecting approximately 1% of adults. This review highlights the therapeutic potential of naturally occurring hormones and their peptides, in both ...
S. J. Getting, M. Kaneva, Y. Bhadresa, D. Renshaw, Giovanna Leoni, H. B. Patel, M. J. P. Kerrigan, I. C. Locke   +7 more
doaj   +1 more source

Molecular evolution of the proopiomelanocortin system in Barn owl species.

PLoS ONE, 2020
Examination of genetic polymorphisms in outbred wild-living species provides insights into the evolution of complex systems. In higher vertebrates, the proopiomelanocortin (POMC) precursor gives rise to α-, β-, and γ-melanocyte-stimulating hormones (MSH),
Karin Löw, Anne-Lyse Ducrest, Luis M San-Jose, Céline Simon, Vera Uva, Nabil G Seidah, Antonella Pasquato, Stefan Kunz, Alexandre Roulin   +8 more
doaj   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source