Results 31 to 40 of about 5,590 (146)

Radioimmunoassay for Alpha Melanocyte Stimulating Hormone

Experimental Biology and Medicine, 1966
SummaryA radioimmunoassay has been developed for alpha melanocyte stimulating hormone (ae MSH). The assay compares favorably with biologic assays in terms of sensitivity and appears to be better in terms of precision and specificity.
G T, Ross, W D, Odell, T, Goodfriend
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α-Melanocyte-Stimulating Hormone–Induced Eruptive Nevi [PDF]

Archives of Dermatology, 2009
Synthetic peptides that target proopiomelanocortin receptors are being investigated as a novel and safe way to tan. It has been postulated that synthetic alpha-melanocyte-stimulating hormone (alpha-MSH) peptides may have protective effects against the development of melanoma because of their melanogenic activity.
Adela R, Cardones, James M, Grichnik
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Effects of the POMC System on Glucose Homeostasis and Potential Therapeutic Targets for Obesity and Diabetes

Diabetes, Metabolic Syndrome and Obesity, 2022
Dan Yang,1,2 Xintong Hou,1,2 Guimei Yang,1,2 Mengnan Li,1,2 Jian Zhang,1,2 Minmin Han,1,2 Yi Zhang,3 Yunfeng Liu1 1Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2First Clinical Medical ...
Yang D, Hou X, Yang G, Li M, Zhang J, Han M, Zhang Y, Liu Y   +7 more
doaj  

Gene transfer to chicks using lentiviral vectors administered via the embryonic chorioallantoic membrane.

PLoS ONE, 2012
The lack of affordable techniques for gene transfer in birds has inhibited the advancement of molecular studies in avian species. Here we demonstrate a new approach for introducing genes into chicken somatic tissues by administration of a lentiviral ...
Gideon Hen, Sara Yosefi, Dmitry Shinder, Adi Or, Sivan Mygdal, Reba Condiotti, Eithan Galun, Amir Bor, Dalit Sela-Donenfeld, Miriam Friedman-Einat   +9 more
doaj   +1 more source

Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist

Nature Communications
The melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety.
Thomas Fontaine, Andreas Busch, Toon Laeremans, Stéphane De Cesco, Yi-Lynn Liang, Veli-Pekka Jaakola, Zara Sands, Sarah Triest, Simonas Masiulis, Lies Dekeyzer, Noor Samyn, Nicolas Loeys, Lisa Perneel, Melanie Debaere, Murielle Martini, Charlotte Vantieghem, Richa Virmani, Kamila Skieterska, Stephanie Staelens, Rosa Barroco, Maarten Van Roy, Christel Menet   +21 more
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The Role of Proopiomelanocortin and α-Melanocyte-Stimulating Hormone in the Metabolic Syndrome in Psychiatric Disorders: A Narrative Mini-Review

Frontiers in Psychiatry, 2019
The metabolic syndrome (MetS) comprises abdominal obesity, preclinical or full diabetes type 2, arterial hypertension, and dyslipidemia and affects a significant proportion of the general population with a remarkably higher prevalence in patients ...
Stefan Raue, Dirk Wedekind, Jens Wiltfang, Jens Wiltfang, Jens Wiltfang, Ulrike Schmidt, Ulrike Schmidt   +6 more
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Psychobiology of feeding behaviour

Dialogues in Clinical Neuroscience & Mental Health, 2018
Adequate nutrition is essential for survival and therefore is ensured by a complex brain system regulating the levels of various nutrients in the blood and in the body stores.
George Konstantakopoulos
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Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro

Frontiers in Pharmacology, 2018
It is now well established that GPR139, a G-protein coupled receptor exclusively expressed in the brain and pituitary, is activated by the essential amino acids L-tryptophan (L-Trp) and L-phenylalanine (L-Phe) via Gαq-coupling.
Diane Nepomuceno, Chester Kuei, Curt Dvorak, Timothy Lovenberg, Changlu Liu, Pascal Bonaventure   +5 more
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Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging

Molecular Metabolism
Objective: The central melanocortin system, composed of peptides derived from pro-opiomelanocortin (POMC) such as the melanocyte-stimulating hormones (α-, β-, γ-MSH) and melanocortin 4 receptors (MC4R), along with the agouti-related protein (AgRP), plays
Yoon Namkung, Tal Slutzki, Joao Pedroso, Xiaohong Liu, Paul V. Sabatini, Maia V. Kokoeva, Stéphane A. Laporte   +6 more
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Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance

Molecular Metabolism, 2018
OBJECTIVE: Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy balance. Desacetyl-α-MSH, the precursor for α-MSH, is present in brain and blood.
Mountjoy, Kathleen G., Caron, Alexandre, Hubbard, Kristina, Shome, Avik, Grey, Angus C., Sun, Bo, Bould, Sarah, Middleditch, Martin, Pontré, Beau, McGregor, Ailsa, Harris, Paul W.R., Kowalczyk, Renata, Brimble, Margaret A., Botha, Rikus, Tan, Karen M.L., Piper, Sarah J., Buchanan, Christina, Lee, Syann, Coll, Anthony P., Elmquist, Joel K.   +19 more
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