Results 61 to 70 of about 6,975 (237)

Stress alters hypothalamic gene expression in adolescent male Golden hamsters

Journal of Neuroendocrinology, EarlyView.
Abstract In Golden hamsters (Mesocricetus auratus), a two‐week exposure to chronic social stress in adolescence causes acceleration of agonistic behavior, enhanced adult aggression, impaired waiting impulsivity, and higher food intake, body fat, and long‐term increased body weight.
Kevin M. Moran, Tyler M. Milewski, James P. Curley, Yvon Delville   +3 more
wiley   +1 more source

Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice

Molecular Metabolism, 2019
Objective: Life-threatening hypoglycemia is a major limiting factor in the management of diabetes. While it is known that counterregulatory responses to hypoglycemia are impaired in diabetes, molecular mechanisms underlying the reduced responses remain ...
Benjamin P. Tooke, Hui Yu, Jessica M. Adams, Graham L. Jones, Talisha Sutton-Kennedy, Lakshmi Mundada, Nathan R. Qi, Malcolm J. Low, Kavaljit H. Chhabra   +8 more
doaj  

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies

Obesity Reviews, EarlyView.
ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin, Stjepan Eržen, Zala Mlinarič, Dubravka Jurišić Eržen, Simon Horvat, Tanja Kunej, Jasna Klen   +6 more
wiley   +1 more source

Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially Impact Schwann and Olfactory Ensheathing Cell Development Without Disrupting GnRH‐1 Migration

Glia, Volume 73, Issue 10, Page 2077-2097, October 2025.
Main Points OECs, SCs, and Mel derive from SCPs. Sox10Cre;YapHet;TazKO mice show impaired SC maturation, reduced Mel formation, fewer SCPs, OECs, and olfactory neurons, but normal GnRH‐1 neuron migration. ABSTRACT Olfactory Ensheathing Cells (OECs) are glial cells originating from the neural crest and are critical for bundling olfactory axons to the ...
Ed Zandro M. Taroc, Enrico Amato Jr., Alexis M. Semon, Nikki Dolphin, Briane Beck, Sophie Belin, Yannick Poitelon, Paolo E. Forni   +7 more
wiley   +1 more source

Quantum Chemical, Spectroscopic and In Silico (Molecular Docking, Molecular Dynamic and ADME) Studies on Anti‐Aging Pentapeptide‐3 (Vialox)

International Journal of Quantum Chemistry, Volume 125, Issue 15, August 5, 2025.
This study investigates the anti‐aging potential of Pentapeptide‐3 (Vialox) using quantum chemical, spectroscopic, and in silico methods. Molecular docking and dynamics analysis confirm its stable interactions with key aging‐related receptors, highlighting Pentapeptide‐3 as a promising candidate for cosmeceutical applications targeting skin aging ...
Dilan Akhan, Bilge Bicak, Serda Kecel Gunduz, Elif Akalin   +3 more
wiley   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

Studies on pituitary polypeptide hormones. 1. The structure of β-melanocyte-stimulating hormone from pig pituitary glands [PDF]

, 1959
J. Ieuan Harris, P. Roos
openalex   +1 more source

Photoprotective, Antioxidant and Anti‐Inflammatory Effects of Aged Punica granatum Extract: In Vitro and In Vivo Insights

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
This study evaluates the bioactivity of an aged pomegranate extract (APEx) on human skin. HPLC‐MS identified key compounds: ellagic acid, punicalagin, and urolithin A. In vitro assays confirmed antioxidant, anti‐inflammatory, and low cytotoxic potential.
Yuki Ikeda, Mizuho Nasu, Jean‐Yves Bruxer, Rocío Díaz‐Puertas, Jesica Martínez‐Godfrey, Darya Bulbiankova, María Herranz‐López, Vicente Micol, Francisco Javier Álvarez‐Martínez   +8 more
wiley   +1 more source

Pharmacological and Therapeutic Properties of the Caucasian Whortleberry (Vaccinium arctostaphylos L.): An Overview of the New Findings

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
This review covers the ethnomedical applications, phytochemical composition, and pharmacological properties of various extracts from different parts of V. arctostaphylos, with a particular focus on the aerial parts and fruits of this medicinal plant. In Iranian traditional medicine, V.
Hesam Bighamanganeh, Maryam Salabati, Abbas Khalilpour, Mohsen Akbaribazm, Nabi Akbarnezhad   +4 more
wiley   +1 more source