Results 101 to 110 of about 62,888 (340)

Shedding light on melanins within in situ human eye melanocytes using 2-photon microscopy profiling techniques. [PDF]

, 2019
Choroidal melanocytes (HCMs) are melanin-producing cells in the vascular uvea of the human eye (iris, ciliary body and choroid). These cranial neural crest-derived cells migrate to populate a mesodermal microenvironment, and display cellular functions ...
Cherepanoff, Svetlana, Conway, Robert Max, Gratton, Enrico, Macmillan, Alexander, Madigan, Michele C, Sitiwin, Ephrem, Whan, Renee   +6 more
core  

Biology of advanced uveal melanoma and next steps for clinical therapeutics [PDF]

, 2014
Uveal melanoma is the most common intraocular malignancy although it is a rare subset of all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with widely divergent patient outcomes.
Bastian, BC, Bowcock, AM, Carvajal, RD, Flaherty, KT, Gershenwald, JE, Gutkind, JS, Luke, JJ, McKenna, KC, Patel, PM, Sato, T, Selig, S, Sossman, JA, Streicher, HZ, Sznol, M, Thurin, M, Triozzi, PL, Van Meir, EG, Welch, J   +17 more
core   +1 more source

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

Barrier Immunity, EarlyView.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia, Mathias Hochgerner, Qingzhen Wei, Xian'ge Zhong, Jiucun Wang   +4 more
wiley   +1 more source

Unraveling Vitiligo: From Immune Mechanisms to Promising Therapeutic Strategies [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Vitiligo is a dermatological condition affecting 1% of the global population, characterized by the loss of skin pigmentation. It appears in two main forms: nonsegmental (symmetrical depigmentation) and segmental (localized depigmentation).
Artur Kovenskiy, Nurlubek Katkenov, Zhussipbek Mukatayev, Almagul Kushugulova   +3 more
doaj   +1 more source

Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially Impact Schwann and Olfactory Ensheathing Cell Development Without Disrupting GnRH‐1 Migration

Glia, EarlyView.
OECs, SCs, and Mel derive from SCPs. Sox10Cre;YapHet;TazKO mice show impaired SC maturation, reduced Mel formation, fewer SCPs, OECs, and olfactory neurons, but normal GnRH‐1 neuron migration. ABSTRACT Olfactory Ensheathing Cells (OECs) are glial cells originating from the neural crest and are critical for bundling olfactory axons to the brain.
Ed Zandro M. Taroc, Enrico Amato Jr., Alexis M. Semon, Nikki Dolphin, Briane Beck, Sophie Belin, Yannick Poitelon, Paolo E. Forni   +7 more
wiley   +1 more source

A Case of Polypoid Intraoral Nevus in Buccal Mucosa: a Case Report

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2020
BACKGROUND AND OBJECTIVE: Mouth discoloration can be of internal or external origin. Melanotic nevus are the result of benign proliferation of melanocytes, the intraoral type of which is not as common as melanotic skin moles.
S Baghery moghadam, N Mortazavi, AR Ahmadinia, F Mirzaei   +3 more
doaj  

Long non-coding RNAs in cutaneous melanoma : clinical perspectives [PDF]

, 2017
Metastatic melanoma of the skin has a high mortality despite the recent introduction of targeted therapy and immunotherapy. Long non-coding RNAs (lncRNAs) are defined as transcripts of more than 200 nucleotides in length that lack protein-coding ...
Brochez, Lieve, Hulstaert, Eva, Mestdagh, Pieter, Vandesompele, Jo, Volders, Pieter-Jan   +4 more
core   +1 more source

Remolding Microenvironmental Homeostasis for Enhancing Regenerative Hypertrophic Scar Treatment Based on Functionalized Microneedles

Interdisciplinary Materials, EarlyView.
This study explores the dysregulated “mitophagy–apoptosis–inflammation” axis in hypertrophic scar (HS) pathophysiology and proposes a synergistic therapy to restore microenvironmental homeostasis. By targeting mitochondrial dysfunction and inflammatory signaling, the strategy enhances scar regression, providing a novel clinical approach for HS ...
Shengjie Jiang, Jialiang Zhou, Liyun Wang, Xin Liu, Jiaming Sun, Yu Zhuang, Li Yu, Haiyan Li, Dejian Li, Zhaoyong Zou, Zhen Gao, Kaili Lin   +11 more
wiley   +1 more source

Antimicrobial peptides: agents of border protection for companion animals. [PDF]

, 2012
Over the past 20 years, there have been significant inroads into understanding the roles of antimicrobial peptides in homeostatic functions and their involvement in disease pathogenesis.
Affolter, Verena K, Bevins, Charles L, Leonard, Brian C   +2 more
core   +1 more source

SOX10, MITF, and microRNAs: Decoding their interplay in regulating melanoma plasticity

International Journal of Cancer, EarlyView.
Abstract Recent studies show that the dysregulation of the transcription factor SOX10 is essential for the development and progression of melanoma. MicroRNAs (miRNAs) can regulate the expression of transcription factors at the post‐transcriptional level. The interactions between SOX10 and its targeting miRNAs form network motifs such as feedforward and
Xin Lai, Chunyan Luan, Zhesi Zhang, Anja Wessely, Markus V. Heppt, Carola Berking, Julio Vera   +6 more
wiley   +1 more source