Results 111 to 120 of about 92,933 (386)

Exploring the Molecular Pathways Underlying the Anti‐Diabetic Effects of Millets

Food Safety and Health, EarlyView.
Millet consumption may modulate gluconeogenesis and glycolysis, enhance glucose transporter activity, increase leptin levels, inhibit the NF‐κB pathway, and mitigate oxidative and nitrosative stress. ABSTRACT Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemic conditions resulting from inadequate insulin production or ...
Akash Kumar, Nidhi N. Shah, Mehul R. Chorawala, Rekha Kaushik, Bhupendra Prajapati, Rahul Mehra   +5 more
wiley   +1 more source

SOX10, MITF, and microRNAs: Decoding their interplay in regulating melanoma plasticity

International Journal of Cancer, EarlyView.
Abstract Recent studies show that the dysregulation of the transcription factor SOX10 is essential for the development and progression of melanoma. MicroRNAs (miRNAs) can regulate the expression of transcription factors at the post‐transcriptional level. The interactions between SOX10 and its targeting miRNAs form network motifs such as feedforward and
Xin Lai, Chunyan Luan, Zhesi Zhang, Anja Wessely, Markus V. Heppt, Carola Berking, Julio Vera   +6 more
wiley   +1 more source

Large Melanosome Complex Is Increased in Keratinocytes of Solar Lentigo

Cosmetics, 2017
Solar lentigo (SL) is characterized by macular lesions exhibiting epidermal hyperplasia combined with hyperpigmentation along with irregular elongation of epidermal rete ridges.
Kazuhisa Maeda
doaj   +1 more source

Influence of Inflammatory Mediators and Cytokines on Human Melanocyte Function [PDF]

, 1993
The fully differentiated human melanocyte functions as a necessary and integral part of the epidermis, synthesizing melanin in intracellular organelles and transferring these pigment-containing organelles to surrounding keratino-cytes.
Morelli, Joseph G., Norris, David A.
core   +1 more source

A Case of Primary Urethral Malignant Melanoma With Persistent Bleeding and Severe Anemia

IJU Case Reports, EarlyView.
ABSTRACT Introduction Primary malignant melanomas of the urethra are extremely rare. The initial symptoms typically include hematuria or genital bleeding. This report describes a case of a massive primary urethral malignant melanoma with persistent bleeding.
Tatsuma Juichi, Go Noguchi, Yuki Yokoi, Daisuke Yamashita, Shuko Yoneyama, Kazuhide Makiyama, Akitoshi Takizawa   +6 more
wiley   +1 more source

Evans Medicine [PDF]

, 1988
Newsletter of the Evans Memorial Department of Clinical Research and Preventive Medicine at University ...
University Hospital, Evans Memorial Department of Clinical Research and Preventive Medicine
core  

Plant extracellular vesicles: A promising bionic medicine platform for disease treatment and drug delivery

Interdisciplinary Medicine, EarlyView.
We introduced the basic characterization and isolation methods of PEVs, reviewed the PEVs‐related articles pertaining to disease therapy and drug delivery system, and summarized the drug loading methods, storage techniques, and engineering modification strategies of the carrier, to establish a safer, more efficient and more affordable approach for ...
Jichun Yang, Yuhan Wang, Yunqian Fu, Sitong Wang, Yao Luo, Xin Cui, Chenyu Sun, Jianing Ji, Jiaxi Mo, Yang Wang, Yilin Liu, Xinghong Hu, Xiaohui Chen, Yimin Jia, Yang Luo   +14 more
wiley   +1 more source

Optimized reconstruction of the absorption spectra of kidney tissues from the spectra of tissue components using the least squares method

Journal of Biophotonics, EarlyView.
The absorption coefficient spectra of healthy and cancerous kidney tissues were reconstructed from the absorption spectra of tissue components using constant weights. Both reconstructions allowed to calculate the concentrations of the tissue components and a comparison between the healthy and chromophobe renal cell carcinoma kidney showed an increase ...
Maria R. Pinheiro, Luís E. Fernandes, Isa C. Carneiro, Sónia D. Carvalho, Rui M. Henrique, Valery V. Tuchin, Hélder P. Oliveira, Luís M. Oliveira   +7 more
wiley   +1 more source

5-ht inhibition of rat insulin 2 promoter cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus [PDF]

, 2009
A number of anti-obesity agents have been developed that enhance hypothalamic 5-HT transmission. Various studies have demonstrated that arcuate neurons, which express proopiomelanocortin peptides (POMC neurons), and neuropeptide Y with agouti-related ...
A.I. Choudhury, Acuna-Castillo, Adham, Bai, Baxter, Beer, Bonnin, Broberger, Brown, Choudhury, Claret, Clemett, Cone, Cowley, Cui, D.J. Withers, Ellacott, Halford, Hansen, Heisler, Heisler, Hoyer, Hoyer, Ioannides-Demos, K. Hisadome, Katayama, Kennett, Kennett, Kilpatrick, Könner, Lovenberg, Lucas, M. Claret, M.A. Smith, M.L.J. Ashford, Makarenko, Muraki, Niswender, Peters, Plum, Ramboz, Ramos, Raymond, Roseberry, Schiavi, Schwartz, Selkirk, Smith, Tecott, Tiligada   +49 more
core   +3 more sources

A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors

PLoS Genetics, 2013
During embryogenesis, the transcription factor, Sox10, drives the survival and differentiation of the melanocyte lineage. However, the role that Sox10 plays in postnatal melanocytes is not established.
Melissa L. Harris, Kristina Buac, O. Shakhova, R. Hakami, M. Wegner, L. Sommer, W. Pavan   +6 more
semanticscholar   +1 more source