Results 151 to 160 of about 92,933 (386)

Endothelial Cell, Pericyte, and Perivascular Resident Macrophage-Type Melanocyte Interactions Regulate Cochlear Intrastrial Fluid–Blood Barrier Permeability

Journal of the Association for Research in Otolaryngology, 2012
The integrity of the fluid–blood barrier in the stria vascularis is critical for maintaining inner ear homeostasis, especially for sustaining the endocochlear potential, an essential driving force for hearing function.
Lingling Neng, Fei Zhang, Allan Kachelmeier, Xiaorui Shi   +3 more
semanticscholar   +1 more source

Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging

Aging Cell, EarlyView.
Age‐related increases in IGF‐1 expression in the skin accelerate stem cell exhaustion and senescence by impairing SIRT1 function, ultimately driving hair follicle aging. Conversely, activating SIRT1, clearing senescent cells, or adopting dietary restriction can mitigate excessive IGF‐1 signaling and provide a promising strategy to rejuvenate hair ...
Yang Wang, Jian Yang, Yue Luo, Zhiqiang Zhao, Yawen Yuan, Juan Li, Yang Liu, Yong Yi, Xiaoke Xu, Yuankunyu Lan, Juan Zou, Qintong Li, Liang Wang, Yang Pan, Yuanhan Yang, Muzhao Xiong, Min Wu, Jinsong Li, Weiyuxin Li, Yujun Zhang, Yang Cao, Yi Zhu, Zhi‐Xiong Jim Xiao   +22 more
wiley   +1 more source

c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.

Genes & Development, 2000
Microphthalmia (Mi) is a bHLHZip transcription factor that is essential for melanocyte development and postnatal function. It is thought to regulate both differentiated features of melanocytes such as pigmentation as well as proliferation/survival, based
Min Wu, T. Hemesath, Clifford M. Takemoto, M. Horstmann, Audrey G. Wells, E. Price, Daniel Z. Fisher, D. Fisher   +7 more
semanticscholar   +1 more source

Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells

Aging Cell, EarlyView.
Expression of HIRA in embryonic melanoblasts is required for proper epigenetic programing and lineage differentiation. Although HIRA deficiency results in a mild phenotype at birth and young adulthood, the melanocytic lineage is sensitive to proliferative challenge, prone to loss of stem cells and dramatically accelerated hair greying in later life ...
Farah Jaber‐Hijazi, Rouven Arnold, Karthic Swaminathan, Kathryn Gilroy, Alexander T. Wenzel, Anthony Lagnado, Kristina Kirschner, Neil Robertson, Claire Reid, Neil Fullarton, Jeff Pawlikowski, Taranjit Singh Rai, Ian Baranyk, Christina Huan Shi, Kevin Y. Yip, Karen Blyth, Jill P. Mesirov, Melissa L. Harris, João F. Passos, Laura M. Machesky, Peter D. Adams   +20 more
wiley   +1 more source

Premature hair graying: a multifaceted phenomenon. [PDF]

Int J Dermatol
Abstract Premature hair graying (PHG) is the early loss of natural hair color, influenced by genetic, biological, and environmental factors. This review discusses the significant psychological impacts of PHG and explores its underlying mechanisms, related health conditions, and available treatments.
Desai DD, Karim M, Nohria A, Needle C, Brinks A, Kearney CA, Ridge A, Mesinkovska N, Shapiro J, Lo Sicco KI.   +9 more
europepmc   +2 more sources

Prevention of Post‐Inflammatory Hyperpigmentation in Skin of Colour: A Systematic Review

Australasian Journal of Dermatology, Volume 66, Issue 3, Page 119-126, May 2025.
ABSTRACT Background/Objectives Post‐inflammatory hyperpigmentation (PIH) impacts all skin tones with a heightened predilection for Fitzpatrick skin types (FST) III‐VI. Preventative measures include pre‐ and post‐intervention approaches, such as sunscreen and corticosteroids. This systematic review aims to summarise the preventative measure outcomes for
Kristie Mar, Mahan Maazi, Bushra Khalid, Rayan Ahmed, Ou Jia (Emilie) Wang, Touraj Khosravi‐Hafshejani   +5 more
wiley   +1 more source

Zinc transporter Slc30a1 regulates melanocyte development by interacting with mt2 in zebrafish

European Journal of Cell Biology, 2022
The essential trace element zinc is involved in multiple biological processes including development and metabolism, while its role in melanocyte formation is still unclear. Slc30a1a and Slc30a1b are zinc exporters in zebrafish.
Zhidan Xia, Xiu Yang, Xinying Bi, Xiujuan Tong, Junxia Min, Fudi Wang   +5 more
doaj  

Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

Andrology, EarlyView.
Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert, Sini Laasanen, Mirja Nurmio, Aida Wahlgren, Kirsi Jahnukainen, Kim Eerola, Miisael Nieminen, Opeyemi Olotu, Noora Kotaja, Juho‐Antti Mäkelä, Jorma Toppari   +10 more
wiley   +1 more source

The ever ongoing cosmetic quest to change eye colour

Acta Ophthalmologica, Volume 103, Issue 3, Page 357-362, May 2025.
Abstract Purpose To provide a historical overview of the various efforts to change eye colour for purely cosmetic reasons, along with the associated potential risks and harms. Methods Literature and online search. Results Eye drops containing adrenaline were used during World War II on involuntary inmates of concentration camp Auschwitz‐Birkenau ...
Richard H. C. Zegers
wiley   +1 more source

Characterisation of localised pigment accumulation in brains of eastern grey kangaroos (Macropus giganteus) after clinical disease due to chronic Phalaris species toxicosis

Australian Veterinary Journal, EarlyView.
A progressive tremorgenic syndrome characterised by ataxia and head nodding is well documented in sheep and cattle affected by chronic Phalaris toxicosis (CPT), and is increasingly documented in the eastern grey kangaroo {(EGK), Macropus giganteus} in southeastern Australia.
C El‐Hage, T Chen, L Tatarczuch, J Hufschmid, LF Skerratt, P Whiteley, N Davis, R Ploeg   +7 more
wiley   +1 more source