Results 151 to 160 of about 78,152 (310)

Untrastructure of Melanocyte in Penile Melanosis [PDF]

, 1990
Sung Bin Im, Dongsik Bang
openalex   +1 more source

A model for de novo pigmentation of amelanotic retinal pigment epithelial cells

Acta Ophthalmologica, EarlyView.
Abstract Purpose Retinal Pigment Epithelial (RPE) cells perform critical functions in the visual cycle. Their melanin pigmentation, which is organized into specialized compartments – melanosomes, is highly critical for proper vision. A chemical method to induce pigmentation in a non‐pigmented model of ARPE‐19 cells was applied using L‐DOPA as a ...
Santosh Gupta, Lyubomyr Lytvynchuk, Taras Ardan, Hana Studenovska, Georgina Faura, Lars Eide, Ljubo Znaor, Slaven Erceg, Knut Stieger, Jan Motlik, Goran Petrovski   +10 more
wiley   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Phenylalanine Lowers Melanin Synthesis in Mammalian Melanocytes by Reducing Tyrosinase Uptake: Implications for Pigment Reduction in Phenylketonuria

, 1980
Richard A. Farishian, J.H. Writtaker
openalex   +1 more source

1242 A natural compound harmine decreases melanin synthesis through inhibition of DYRK1A in human skin melanocytes [PDF]

, 2018
Chulwhan Park, Goon-Bo Kim, Yan Lee, Hyangkyoung Kim, Myoung‐Chong Song, Daewon Lee, Jin Ho Chung   +6 more
openalex   +1 more source

Exosomes released by melanocytes modulate fibroblasts to promote keloid formation: a pilot study

, 2022
Zeren Shen, Jinjin Shao, Jiaqi Sun, Jinghong Xu   +3 more
openalex   +2 more sources

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Interaction between α-Melanocyte-Stimulating Hormone and Corticotropin-Releasing Hormone in the Regulation of Feeding and Hypothalamo-Pituitary-Adrenal Responses [PDF]

, 2003
Xin‐Yun Lu, Gregory S. Barsh, Huda Akil, Stanley J. Watson   +3 more
openalex   +1 more source

The Impact of Next‐Generation Sequencing on Interobserver Agreement and Diagnostic Accuracy of Deep Penetrating Melanocytic Neoplasms

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Next‐generation sequencing (NGS) is becoming more commonly used for diagnosis in dermatopathology. It's critical to appraise its efficacy and limitations. Distinguishing benign deep penetrating nevi (DPN) from deep penetrating like‐melanoma (DPN‐M) is a challenging diagnostic scenario even for experienced dermatopathologists ...
Julia Edwin Jeyakumar, Afua Konadu Addo, Haya Mary Beydoun, Shantel Olivares, Armita Bahrami, Thiagarajah Balamurugan, Raymond L. Barnhill, Willeke A. M. Blokx, Klaus J. Busam, Lorenzo Cerroni, Martin Cook, Arnaud de La Fouchardière, Lyn M. Duncan, David E. Elder, Peter Ferguson, Gerardo Ferrara, Iva Johansson, Jennifer S. Ko, Ji Eun Kwon, Gilles Landman, Cecilia Lezcano, Lori Lowe, Daniela Massi, Jane Messina, Daniela Mihic‐Probst, Douglas C. Parker, Margaret Redpath, Michael R. Sargen, Richard A. Scolyer, Christopher R. Shea, Michael Tetzlaff, Carlos Torres‐Cabala, Victor Tron, Xiaowei Xu, Iwei Yeh, Sook Jung Yun, Artur Zembowicz, Pedram Gerami   +37 more
wiley   +1 more source