Results 211 to 220 of about 62,888 (340)

Lichenoid graft‐versus‐host disease shows a high interferon score, with IFNAR1 inhibition preventing skin inflammation

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
This study identifies interferons as key mediators in lichenoid chronic GVHD pathogenesis, along with Th2 and Th17 involvement. It particularly highlights the role of Type I interferon, showing that early anti‐IFNAR1 treatment reduces skin inflammation in a murine model of chronic cutaneous GVHD.
Chloé Grolleau   +11 more
wiley   +1 more source

Immune checkpoint molecules and spatial transcriptome profiles according to BRAF status in acral melanoma

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
The BRAF mutation in acral melanoma is associated with the expression of immune checkpoint molecules—PD‐1, LAG‐3 and TIM‐3—at both protein and mRNA levels. This suggests an association with the tumour microenvironment, including tumour‐associated immune cells, which influence both anti‐tumour immunity and tumour progression.
Hee Joo Yang   +6 more
wiley   +1 more source

Clinical heterogeneity in vitiligo: Identification of clinical markers based patient clusters

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
Vitiligo is a chronic autoimmune disease with heterogeneous clinical presentations. This study analysed 399 patients using hierarchical clustering and identified five phenotypes based on clinical characteristics and lesion distribution. Two groups exhibited high disease activity and extensive involvement.
Laura Galissi   +8 more
wiley   +1 more source

PAX3 expression patterns in ocular surface melanocytes. [PDF]

open access: yesSci Rep
Ulrich E   +8 more
europepmc   +1 more source

Non‐invasive characterization of melanoma depth at single‐cell resolution

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
Non‐invasive determination of Breslow depth would be beneficial for the clinical management of melanoma. We demonstrate that RSOM can achieve non‐invasive imaging of single melanocytes up to several millimetres in tissue. A pilot clinical study showed a high degree of correlation between RSOM and the standard for Breslow depth determination.
Juan Aguirre   +11 more
wiley   +1 more source

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