Results 191 to 200 of about 53,753 (240)

Spatial architecture of the melanoma immune niche reveals CORO1A as a functional hub for T cell cytotoxicity and immunotherapy synergy. [PDF]

J Transl Med
Zhang S, Wang H, Wu J, Fan P, Liu Y, Ma T, Li L.   +6 more
europepmc   +1 more source

Setmelanotide in Bardet‐Biedl Syndrome: A Case Report

Pediatric Dermatology, EarlyView.
ABSTRACT Setmelanotide is a melanocortin‐4‐receptor agonist used for the treatment of hyperphagia in the genetic obesity syndrome Bardet‐Biedl. Presented is a case of diffuse hyperpigmentation in a patient treated with setmelanotide, which represents the most common side effect of this medication.
Shelby Smith, Eric Sanfilippo, Lara Wine Lee   +2 more
wiley   +1 more source

Single-cell transcriptomic profiling of halo nevi and normal nevi reveals CD8⁺ T cell activation in melanocytic autoimmunity. [PDF]

Front Immunol
Gao W, Lv H, Xie Y, Chang Y, Li B, Chang J, Sun K, Chen T.   +7 more
europepmc   +1 more source

Impact of a Brief Educational Intervention on Parental Sun Safety Attitudes for Newborns

Pediatric Dermatology, EarlyView.
ABSTRACT Early‐life sun exposure accounts for a substantial portion of lifetime UV damage, with much of lifetime risk acquired before age 20 years. Despite clear pediatric and dermatology guidelines, many parents remain unsure of what optimal sun protection means, highlighting the need for accessible education and intervention.
Ayesha Kothari, Kaylee Gwyn, Bashir Khatib‐Shahidi, Faheed Shafau, Elizabeth Buzney   +4 more
wiley   +1 more source

Aberrant laminin signaling drives melanocyte dedifferentiation and unveils a tractable therapeutic target in vitiligo. [PDF]

Nat Commun
Yang F, Yang L, Lai S, Yokota M, Kuroda Y, Yuki T, Takahashi Y, Sayo T, Namiki T, Goto H, Hiroyasu S, Sano S, Inoue S, Mizukami Y, Tsuruta D, Katayama I.   +15 more
europepmc   +1 more source

Clinical Characterization of Skin Findings on the Hands in Proteus Syndrome

Pediatric Dermatology, EarlyView.
ABSTRACT Background Proteus syndrome is a progressive asymmetric overgrowth disorder caused by mosaic activating variants in AKT1. It most frequently affects the skin, soft tissues, bones, and central nervous system and increases the risk for certain tumors and venous thromboembolism. A hallmark feature is the progressive plantar cerebriform connective
Samantha D. Verling, Nicole Gaidici, Leslie G. Biesecker, Thomas N. Darling, Christopher A. Ours   +4 more
wiley   +1 more source

Regulatory T cells in vitiligo: a review of functional disequilibrium between peripheral blood and lesional tissue. [PDF]

Front Immunol
Qiu Y, He Y, Liu F.
europepmc   +1 more source

Cutis Tricolor‐Like Pigmentary Mosaicism in Mowat–Wilson Syndrome: Phenotypic Overlap With Ruggieri–Happle Syndrome

Pediatric Dermatology, EarlyView.
ABSTRACT Cutis tricolor (CT) is a rare pigmentary mosaicism characterized by the coexistence of hyperpigmented and hypopigmented areas on a background of normal skin; its syndromic form, Ruggieri–Happle syndrome (RHS), is associated with neurodevelopmental delay, facial dysmorphism, skeletal abnormalities, and other systemic defects.
Didier Bessis, Pierre Meyer, Marjolaine Willems   +2 more
wiley   +1 more source

SASH1 as a Context-Dependent Multi-Docking Scaffold Linking Receptor Signaling to Cytoskeletal Dynamics. [PDF]

Int J Mol Sci
Clements CM, Roney MSI, Shellman YG.
europepmc   +1 more source

Photoprotective potential of gadusol against ultraviolet B radiation in melanocytes

Photochemistry and Photobiology, EarlyView.
Gadusol protects melanocytes from ultraviolet B (UVB)‐induced damage without cytotoxicity. Abstract The increasing incidence of skin cancer, including melanoma, combined with the need for ultraviolet (UV) filters that are safe for human health and marine ecosystems, is driving the search for new photoprotective agents.
Andressa Mai Matsumoto, Rocío Isla Naveira, Andy Joel Taipe Huisa, Marcelo Augusto Germani Marinho, Lais Zortéa, José María Monserrat, Agueda Elena Massa, María Sandra Churio, Ana Paula de Souza Votto   +8 more
wiley   +1 more source