Results 201 to 210 of about 116,555 (410)

Large Congenital Melanocytic Nevus With LMNA::NTRK1 Fusion: Expanding Targeted Therapy Options for Congenital Nevi and Melanoma

open access: yesJournal of Cutaneous Pathology, EarlyView.
ABSTRACT Large congenital melanocytic nevi/nevus (LCMN) are caused by genetic events that activate the mitogen‐activated protein kinase (MAPK) and extracellular signal‐regulated kinase (ERK) pathway. Individuals with LCMN are prone to developing aggressive melanomas during childhood.
Akanksha Nagarkar   +16 more
wiley   +1 more source

Estrogen synthesized in the central nervous system enhances MC4R expression and reduces food intake

open access: yesThe FEBS Journal, EarlyView.
Estrogen is regulated by the rate‐limiting enzyme aromatase. This study examines how neuroestrogens, estrogen produced in the brain, regulate appetite through the hypothalamus. Using ovariectomized, aromatase knockout, and brain‐specific aromatase‐restored mice, the study found that neuroestrogens suppress appetite by influencing genes like Mc4r.
Takanori Hayashi   +8 more
wiley   +1 more source

Electron Microscopy of Melanocytes in Human Piebaldism*

open access: bronze, 1965
Aodán S. Breathnach   +2 more
openalex   +1 more source

ZNF224 enhances the oncogenic function of p21 via p53 and AKT pathways in melanoma

open access: yesThe FEBS Journal, EarlyView.
KRAB zinc finger protein ZNF224 acts as an oncogenic factor in melanoma cells, enhancing p21 cytosolic retention and impairing nuclear p21 cytostatic activity through stimulation of the AKT pathway. Furthermore, ZNF224 regulates transcriptional expression levels of p21 via p53.
Leandra Sepe   +12 more
wiley   +1 more source

Correlation study of facial lipid profile differences and skin physiological characteristics in Chinese women aged 19–33 years

open access: yesInternational Journal of Cosmetic Science, EarlyView.
The facial SC lipid profiles of young Chinese women in the early aging stage exhibited significant changes with age. The average chain length of diacylglycerol, triacylglycerol and short‐chain ceramides decreases with age, while the cholesteryl ester and ceramide EO subclasses increase. Some ceramides correlate positively with TEWL, skin elasticity and
Yumei Fan   +6 more
wiley   +1 more source

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