Results 91 to 100 of about 283,745 (306)

Nivolumab plus ipilimumab in the treatment of advanced melanoma. [PDF]

, 2015
Advanced melanoma has historically been a difficult disease to treat due to few effective systemic treatment options. However, over the past few years, scientific advancements in immune checkpoint inhibition have resulted in several novel approaches that
Daud, Adil I, Tsai, Katy K
core   +1 more source

Tumor-targeting Salmonella typhimurium A1-R combined with temozolomide regresses malignant melanoma with a BRAF-V600E mutation in a patient-derived orthotopic xenograft (PDOX) model. [PDF]

, 2016
Melanoma is a recalcitrant disease in need of transformative therapuetics. The present study used a patient-derived orthotopic xenograft (PDOX) nude-mouse model of melanoma with a BRAF-V600E mutation to determine the efficacy of temozolomide (TEM ...
Chmielowski, Bartosz, Dry, Sarah M, Eilber, Fritz C, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Yunfeng, Murakami, Takashi, Nelson, Scott D, Russell, Tara A, Singh, Arun, Unno, Michiaki, Zhang, Yong, Zhao, Ming   +14 more
core   +2 more sources

Integrated Visible Light and Oxidant Protection Through Multifunctional Sunscreens

Advanced Healthcare Materials, EarlyView.
High‐energy visible radiation (HEVR), although less energetic than UV light, penetrates deeper into the skin and contributes to photoaging, pigmentation disorders, and oxidative stress. The development of new HEVR‐targeted filters, therefore, represents not only a scientific challenge but also a pressing public health and cosmetic industry need.
Beatriz Peñín, Raúl Losantos, Ignacio Funes‐Ardoiz, Diego Sampedro   +3 more
wiley   +1 more source

A comparative study of different strategies of batch effect removal in microarray data: a case study of three datasets [PDF]

, 2013
Batch effects refer to the systematic non-biological variability that is introduced by experimental design and sample processing in microarray experiments.
Ding, Fei
core  

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours [PDF]

, 2016
Natural killer (NK) lymphocytes are part of the innate immune system and are important in immune protection against tumourigenesis. NK cells display a broad repertoire of activating and inhibitory cell surface receptors that regulate NK cell activity ...
Filtjens, Jessica, Keirsse, Jiri, Kerre, Tessa, Leclercq, Georges, Plum, Jean, Taghon, Tom, Taveirne, Sylvie, Van Acker, Aline, Van Ammel, Els, Van Ginderachter, Jo A, Vandekerckhove, Bart   +10 more
core   +2 more sources

Bioorthogonal Photoactivation of 2‐Nitrobenzyl Caged Doxorubicin Anticancer Prodrugs on Gold Nanostars

Advanced Materials, EarlyView.
Bioorthogonal chemistry was applied to intracellularly photoactivate Doxorubicin (Dox) using gold nanostars (AuNSt) and near‐infrared (NIR) light. Two prodrugs were used: one photoactivatable, masked with 2‐nitrobenzyl carbamate (proDox1) and another photolabile, masked with 2‐nitrobenzyl diol (proDox2), which was attached to the AuNSt surface.
Juan José Esteve‐Moreno, Andrea Escudero, Oscar Ferreira Silvestre, José Manuel Terrés, Mónica Gorbe, Eva Garrido, Carlos Renero‐Lecuna, Judith Langer, María Alfonso, Javier Ibañez, Félix Sancenón, Roberto Cao‐Milán, Luis M. Liz‐Marzán, Alba García‐Fernández, Andy Hernández‐Montoto, Ramón Martínez‐Máñez   +15 more
wiley   +1 more source

Efecto del D-isoproterenol sobre el crecimiento de melanomas experimentales,

Revista de la Facultad de Medicina, 1966
  En un experimento informado anteriormente, se encontró una diferencia apreciable, pero sin significación estadística, en el peso promedio de melanomas en hámsteres inyectados con D-isoproterenol con el de los controles y el de otros grupos ...
José Perea Sasiaín, Alicia Gaitán Cortés   +1 more
doaj  

Cold Atmospheric Plasma‐Activated Decellularized Extracellular Matrix Gel as a Tumor‐Infiltrating Immunoactivation Platform for Post‐Surgical Cancer Immunotherapy

Advanced Materials, EarlyView.
An injectable cold atmospheric plasma‐activated decellularized tumor extracellular matrix hydrogel is introduced as a post‐surgical immunoactivation platform. The engineered gel attracts residual tumor cells and induces immunogenic cell death, reshaping the tumor microenvironment and eliciting systemic antitumor immunity. In combination with checkpoint
Tianxu Fang, Mo Chen, Yueyang Deng, Tianqin Ning, Tianwen Luo, Guojun Chen   +5 more
wiley   +1 more source

The lincRNA MIRAT binds to IQGAP1 and modulates the MAPK pathway in NRAS mutant melanoma. [PDF]

, 2018
Despite major advances in targeted melanoma therapies, drug resistance limits their efficacy. Long noncoding RNAs (lncRNAs) are transcriptome elements that do not encode proteins but are important regulatory molecules.
Burlingame, Alma, Daud, Adil, Dimon, Michelle, Esteve-Puig, Rosaura, Gajjala, Abhinay, Gho, Deborah, Ho, Wilson, Johnston, Katia, Lai, Kevin, Lin, Kevin, Moy, Adrian, Ortiz-Urda, Susana, Oses Prieto, Juan, Posch, Christian, Rappersberger, Klemens, Sanlorenzo, Martina, Vujic, Igor, Vujic, Marin, Zekhtser, Mitchell   +18 more
core   +1 more source

Metamaterial Antennas Enhance MRI of the Eye and Occipital Brain

Advanced Materials, EarlyView.
A radiofrequency antenna platform comprising planar and bend configurations is developed, incorporating structurally integrated epsilon‐negative metamaterial unit cells to enhance MRI. These antennas enable high‐resolution in vivo human MRI of the eye, orbit, and occipital brain. Comprehensive validation, including simulations, phantom experiments, SAR,
Nandita Saha, Bilguun Nurzed, Mostafa Berangi, Andre Kuehne, Helmar Waiczies, Igor Fabian Tellez Ceja, Xiang Hu, Thomas Gladytz, Lisa Krenz, Dave Huebler, Beate Endemann, Claudia Brockmann, Ebba Beller, Oliver Stachs, Thoralf Niendorf   +14 more
wiley   +1 more source