Results 161 to 170 of about 283,745 (306)

Astragalus Polysaccharides Induce Immunogenic Cell Death in Melanoma: A Mechanism Mediated by cGAS/STING Activation via Intratumoral Microbiota Modulation. [PDF]

Cancer Med
Qiao X, Ding G, Lu Q, Chen Y, Wang X, Wang Y, Ma J, Cheng X.   +7 more
europepmc   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

First-line Nivolumab plus Ipilimumab in patients with advanced melanoma previously treated with adjuvant systemic therapy

EJC Skin Cancer
K. Kisielewska, K. Kozak, P. Teterycz, Ł. Galus, J. Mackiewicz, P. Brandys, B. Cybulska-Stopa, N. Kempa-Kamińska, M. Ziętek, J. Żubrowska, R. Dziura, P. Sobczuk, A.M. Czarnecka, P. Rutkowski   +13 more
doaj   +1 more source

Melanoma cells secrete follistatin, an antagonist of activin-mediated growth inhibition [PDF]

, 2004
Bracke, Marc, Devreese, Bart, Mareel, Marcus, Stove, Christophe, Van Beeumen, Jozef, Vanrobaeys, Frank   +5 more
core   +2 more sources

Plasticity, signaling, and metabolic rewiring in melanoma persister cells. [PDF]

Commun Biol
Sensenbach S, Ngo HG, Orman MA.
europepmc   +1 more source

scResponse: A Rank‐Based Method for Identifying Cell States That Contribute to Immunotherapy Response by Single‐Cell Data

Advanced Science, EarlyView.
Although the tumor microenvironment is known to shape immunotherapy response, its key determinants remain elusive, underscoring the critical need for single‐cell resolution analytical frameworks. We present scResponse, an efficient algorithm to quantify single‐cell responses to immunotherapy. By capturing diverse cellular subtypes and states associated
Qi Dong, Haijun Huang, Yuxiu Wang, Bo Jiang, Yuzheng Chen, Huanhuan Xu, Jing Ren, Shengnan Guo, Tianhao Li, Mingjie Zhang, Tianyu Zhai, Wenbo Yang, Kaidong Liu, Cheng Lyu, Jingxuan Kang, Mingshuo Zhang, Yupeng Lu, Binghui Si, Shujun Cao, Dandan Xu, Zong Chen, Dapeng Hao   +21 more
wiley   +1 more source

Pregnancy Associated Melanoma: Diagnostic and Therapeutic Challenges. [PDF]

Medicina (Kaunas)
Atanasescu VP, Atanasescu IE, Mehedintu C, Ristea MR, Alexandru AN, Dogaru IM, Boga BM, Oproiu AM.   +7 more
europepmc   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Author Correction: Tumour gene expression signature in primary melanoma predicts long-term outcomes

Nature Communications, 2022
Manik Garg, Dominique-Laurent Couturier, Jérémie Nsengimana, Nuno A. Fonseca, Matthew Wongchenko, Yibing Yan, Martin Lauss, Göran B. Jönsson, Julia Newton-Bishop, Christine Parkinson, Mark R. Middleton, D. Timothy Bishop, Sarah McDonald, Nikki Stefanos, John Tadross, Ismael A. Vergara, Serigne Lo, Felicity Newell, James S. Wilmott, John F. Thompson, Georgina V. Long, Richard A. Scolyer, Pippa Corrie, David J. Adams, Alvis Brazma, Roy Rabbie   +25 more
doaj   +1 more source

Photo-immunotherapeutic PDA-Ce6-R837 nanoparticles enhance the induction of immunogenic responses in melanoma cells. [PDF]

RSC Adv
Wang J, Liu C, Zhang X, Xie Y, Zhang X, Wang T, Wang L.   +6 more
europepmc   +1 more source