Results 71 to 80 of about 528,594 (306)
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Dermatology ReportsBackground: Sentinel lymph node biopsy (SLNB) in melanoma allows the identification of patients with clinically non-palpable metastatic lymph nodes. The risk of nodal involvement is related to Breslow thickness, ulceration, or mitotic rate.
Italian Melanoma Intergroup
doaj +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Dermatology ReportsBackground: Immunotherapy has significantly improved survival outcomes in metastatic melanoma. Following the Checkmate 067, in January 2022, the Italian Medicines Agency (AIFA) approved combination of Nivolumab+Ipilimumab for the treatment of metastatic
Italian Melanoma Intergroup
doaj +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Approaches to the study of FKBP51 for development of a novel melanoma biomarker.
, 2011 Very recently, we have identified that FKBP51 controls response of melanoma to DNA damaging agents. In particular, we found that FKBP51-silencing activated apoptosis in irradiated melanoma, both in vitro and in vivo. Increased levels of FKBP51 were found
ROMANO, MARIA FIAMMETTA
core
Dermatology ReportsBackground: Conjunctival melanoma is a rare but aggressive ocular tumor with high metastatic potential leading to 30% mortality rate. Standard treatment relies on surgery and brachytherapy, but local recurrence and mutilating procedures (e.g ...
Italian Melanoma Intergroup
doaj +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Identificação de biomarcadores terapêuticos em melanoma
, 2011 Mestrado em Biomedicina MolecularO melanoma deriva da transformação maligna de melanócitos e é frequentemente encontrado na pele e na região ocular. A identificação de marcadores moleculares que inequivocamente indiquem a agressividade do tumor ou que
Tavares, Sandra Raquel de Oliveira
core
Dermatology ReportsBackground: Sentinel lymph node biopsy (SLNB) is key for melanoma staging, but its value in thinner lesions is debated, with current predictive models often underestimating positivity. Methods: We retrospectively analyzed 511 patients with pT1a (8.6%),
Italian Melanoma Intergroup
doaj +1 more source