Results 61 to 70 of about 7,378 (211)

Molecular Aspects of Eye Evolution and Development: From the Origin of Retinal Cells to the Future of Regenerative Medicine [PDF]

, 2013
A central issue of evolutionary developmental biology is how the eye is diverged morphologically and functionally. However, the unifying mechanisms or schemes that govern eye diversification remain unsolved.
Ohuchi, Hideyo
core   +1 more source

The Ecology of Human Sleep (EcoSleep) Cohort Study: Protocol for a longitudinal repeated measurement burst design study to assess the relationship between sleep determinants and outcomes under real‐world conditions across time of year

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary The interplay of daily life factors, including mood, physical activity, or light exposure, influences sleep architecture and quality. Laboratory‐based studies often isolate these determinants to establish causality, thereby sacrificing ecological validity.
Anna M. Biller, Nayab Fatima, Chrysanth Hamberger, Laura Hainke, Verena Plankl, Amna Nadeem, Achim Kramer, Martin Hecht, Manuel Spitschan   +8 more
wiley   +1 more source

Synaptic Contact between Melanopsin-Containing Retinal Ganglion Cells and Rod Bipolar Cells

Investigative Opthalmology & Visual Science, 2007
Evidence indicates that the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs) receive input from rods and cones, which are thought to modulate the irradiance detecting system driving entrainment of the circadian system and pupillomotor control.
Jens, Østergaard, Jens, Hannibal, Jan, Fahrenkrug   +2 more
openaire   +2 more sources

G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.

PLoS ONE, 2015
Phosphorylation is a primary modulator of mammalian G-protein coupled receptor (GPCR) activity. The GPCR melanopsin is the photopigment of intrinsically photosensitive retinal ganglion cells (ipRGCs) in the mammalian retina. Recent evidence from in vitro
Timothy J Sexton, Russell N Van Gelder
doaj   +1 more source

Phosphorylation of mouse melanopsin by protein kinase A.

PLoS ONE, 2012
The visual pigment melanopsin is expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs) in the mammalian retina, where it is involved in non-image forming light responses including circadian photoentrainment, pupil constriction ...
Joseph R Blasic, R Lane Brown, Phyllis R Robinson   +2 more
doaj   +1 more source

Randomized trial of polychromatic blue-enriched light for circadian phase shifting, melatonin suppression, and alerting responses. [PDF]

, 2019
Wavelength comparisons have indicated that circadian phase-shifting and enhancement of subjective and EEG-correlates of alertness have a higher sensitivity to short wavelength visible light.
Ayers, M., Brainard, G. C., Byrne, B., Cecil, K., Gerner, E., Hanifin, J. P., Jablonski, M., James, M., Lockley, S. W., Pineda, C., Rollag, M., Warfield, B., West, K.   +12 more
core   +2 more sources

Pinopsin Regulates Melatonin Production and Daily Locomotor Activity: Functional Insights From Gene‐Edited Xenopus Tadpoles

Journal of Pineal Research, Volume 78, Issue 2, March 2026.
ABSTRACT Circadian rhythm alignment depends on environmental light detection via opsins. Pinopsin, originally identified in the pineal organ of birds and later in amphibian pineal complex and eyes, may play a role in this process, though its function has not been genetically tested.
Neda Heshami, Ricardo D. Romero, Flavio S. J. de Souza, Gabriel E. Bertolesi, Sarah McFarlane   +4 more
wiley   +1 more source

Melanopsin retinal ganglion cells are resistant to neurodegeneration in mitochondrial optic neuropathies [PDF]

Brain, 2010
Mitochondrial optic neuropathies, that is, Leber hereditary optic neuropathy and dominant optic atrophy, selectively affect retinal ganglion cells, causing visual loss with relatively preserved pupillary light reflex. The mammalian eye contains a light detection system based on a subset of retinal ganglion cells containing the photopigment melanopsin ...
LA MORGIA, CHIARA, Ross Cisneros F. N., Sadun A. A., Hannibal J., Munarini A., Mantovani V., Barboni P., Cantalupo G., Tozer K. R., Sancisi E., Salomao S. R., Moraes M. N., Moraes Filho M. N., Heegaard S., Milea D., Kjer P., MONTAGNA, PASQUALE, CARELLI, VALERIO   +17 more
openaire   +4 more sources

Cell-type expression and activation by light of neuropsins in the developing and mature Xenopus retina

Frontiers in Cellular Neuroscience, 2023
Photosensitive opsins detect light and perform image- or nonimage-forming tasks. Opsins such as the “classical” visual opsins and melanopsin are well studied.
Lawrence L. H. Man, Samuel S. Storey, Gabriel E. Bertolesi, Sarah McFarlane   +3 more
doaj   +1 more source

The Effects of Neurosteroids, such as Pregnenolone Sulfate and its receptor, TrpM3 in the Retina. [PDF]

, 2019
Pregnenolone sulfate (PregS) is the precursor to all steroid hormones and is produced in neurons in an activity dependent manner. Studies have shown that PregS production is upregulated during certain critical periods of development, such as in the first
Webster, Corey Michael
core