Results 41 to 50 of about 3,657 (172)

Melanopsin-derived visual responses under light adapted conditions in the mouse dLGN.

PLoS ONE, 2015
A direct projection from melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) reaches the primary visual thalamus (dorsal lateral geniculate nucleus; dLGN).
Katherine E Davis, Cyril G Eleftheriou, Annette E Allen, Christopher A Procyk, Robert J Lucas   +4 more
doaj   +1 more source

Loss of Melanopsin-Expressing Retinal Ganglion Cells in Patients With Diabetic Retinopathy [PDF]

Investigative Opthalmology & Visual Science, 2017
Photo-entrainment of the circadian clock is mediated by melanopsin-expressing retinal ganglion cells (mRGCs) located in the retina. Patients suffering from diabetic retinopathy (DR) show impairment of light regulated circadian activity such as sleep disorders, altered blood pressure, and abnormal melatonin secretion. The aim of this study was to assess
Obara, Elisabeth Anne, Hannibal, Jens, Heegaard, Steffen, Fahrenkrug, Jan   +3 more
openaire   +3 more sources

Retinofugal Projections from Melanopsin-Expressing Retinal Ganglion Cells Revealed by Intraocular Injections of Cre-Dependent Virus.

PLoS ONE, 2016
To understand visual functions mediated by intrinsically photosensitive melanopsin-expressing retinal ganglion cells (mRGCs), it is important to elucidate axonal projections from these cells into the brain.
Anton Delwig, DeLaine D Larsen, Douglas Yasumura, Cindy F Yang, Nirao M Shah, David R Copenhagen   +5 more
doaj   +1 more source

Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation.

PLoS ONE, 2020
Melanopsin is a visual pigment expressed in a small subset of ganglion cells in the mammalian retina known as intrinsically photosensitive retinal ganglion cells (ipRGCs) and is implicated in regulating non-image forming functions such as circadian ...
Juan C Valdez-Lopez, Sahil Gulati, Elelbin A Ortiz, Krzysztof Palczewski, Phyllis R Robinson   +4 more
doaj   +1 more source

Melanopsin and Cone Photoreceptor Inputs to the Afferent Pupil Light Response

Frontiers in Neurology, 2019
Background: Retinal photoreceptors provide the main stage in the mammalian eye for regulating the retinal illumination through changes in pupil diameter, with a small population of melanopsin-expressing intrinsically photosensitive retinal ganglion cells
Andrew J. Zele, Andrew J. Zele, Prakash Adhikari, Prakash Adhikari, Dingcai Cao, Beatrix Feigl, Beatrix Feigl, Beatrix Feigl   +7 more
doaj   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Characterization of the melanopsin gene (Opn4x) of diurnal and nocturnal snakes

BMC Evolutionary Biology, 2019
Background A number of non-visual responses to light in vertebrates, such as circadian rhythm control and pupillary light reflex, are mediated by melanopsins, G-protein coupled membrane receptors, conjugated to a retinal chromophore.
Einat Hauzman, Venkatasushma Kalava, Daniela Maria Oliveira Bonci, Dora Fix Ventura   +3 more
doaj   +1 more source

Melatonin Levels in 89 Individuals With Smith Magenis Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT In patients with Smith–Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients.
Wiebe Braam, Ann C. M. Smith
wiley   +1 more source

Loss of melanopsin-containing retinal ganglion cells in a rat glaucoma model

Chinese Medical Journal, 2008
Glaucoma can cause progressive damage to retinal ganglion cells. These cells can be classified as cells projecting to the superior colliculus and melanopsin-containing retinal ganglion cells, which project to the suprachiasmatic nucleus. This study was to investigate the effects of chronic intraocular pressure elevation on melanopsin-containing retinal
Huai-zhou, Wang, Qing-jun, Lu, Ning-li, Wang, Hong, Liu, Ling, Zhang, Gui-lin, Zhan   +5 more
openaire   +2 more sources

G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.

PLoS ONE, 2015
Phosphorylation is a primary modulator of mammalian G-protein coupled receptor (GPCR) activity. The GPCR melanopsin is the photopigment of intrinsically photosensitive retinal ganglion cells (ipRGCs) in the mammalian retina. Recent evidence from in vitro
Timothy J Sexton, Russell N Van Gelder
doaj   +1 more source