Results 61 to 70 of about 3,657 (172)
A systematic comparison of optogenetic approaches to visual restoration
Molecular Therapy: Methods & Clinical Development, 2022 During inherited retinal degenerations (IRDs), vision is lost due to photoreceptor cell death; however, a range of optogenetic tools have been shown to restore light responses in animal models. Restored response characteristics vary between tools and the
Michael J. Gilhooley +5 more
doaj +1 more source
Advanced Science, Volume 13, Issue 28, 18 May 2026.Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat +6 more
wiley +1 more source
Frontiers in Neurology, 2021 Glaucoma damages retinal ganglion cells, including intrinsically photosensitive retinal ganglion cells (ipRGCs). These cells modulate various non-visual physiological and psychological functions which are modulated by light. In patients with glaucoma, we
Aki Kawasaki +4 more
doaj +1 more source
Brain and Behavior, Volume 16, Issue 3, March 2026.This study demonstrated that ictal photophobia was present in 89.8% and interictal photophobia in 93.4% of patients. Sleep disturbances were common, with 44.9% reporting difficulty falling asleep. Network analysis revealed stronger associations between interictal photophobia, daytime sleepiness, and medication overuse in chronic migraine compared to ...
Seden Demirci +7 more
wiley +1 more source
Melanopsin contributions to irradiance coding in the thalamo-cortical visual system.
PLoS Biology, 2010 Photoreception in the mammalian retina is not restricted to rods and cones but extends to a subset of retinal ganglion cells expressing the photopigment melanopsin (mRGCs).
Timothy M Brown +9 more
doaj +1 more source
Robust visual cortex evoked potentials (VEP) in Gnat1 and Gnat2 knockout mice
Frontiers in Cellular Neuroscience, 2022 Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin, imparting to themselves the ability to respond to light in the absence of input from rod or cone photoreceptors.
Michael D. Flood +6 more
doaj +1 more source
Journal of Pineal Research, Volume 78, Issue 2, March 2026.ABSTRACT Circadian rhythm alignment depends on environmental light detection via opsins. Pinopsin, originally identified in the pineal organ of birds and later in amphibian pineal complex and eyes, may play a role in this process, though its function has not been genetically tested.
Neda Heshami +4 more
wiley +1 more source
Aging Cell, Volume 25, Issue 2, February 2026.As flies age, their photoreceptor transcriptome is extensively reprogrammed, with about 40% of genes undergoing rhythmic expression changes. These transcriptional changes are accompanied by altered RNA Polymerase II occupancy, chromatin accessibility, and H3K4 methylation, without major changes to the occupancy of the core clock transcription factors ...
Sarah E. McGovern +4 more
wiley +1 more source
Melanopsin Stimulation Modulates Blackness Induction
Color Research &Application, Volume 51, Issue 1, January/February 2026.Spectral power distributions of (A) the surround and (B) the center stimuli. The stimulus intensity to melanopsin cells of the surround was modulated from 0.51 to 1.21 (#1; 0.51, #2; 0.65, #3; 0.78, #4; 0.93, #5; 1.09, #6; 1.21, #7; 0.51, #8; 0.67, #9; 0.95, #10; 1.21) in the melanopic/photopic ratio (M/P ratio) under both the 700 cd/m2 and 375 cd/m2 ...
Masahiko Yamakawa +2 more
wiley +1 more source
Light-Evoked Calcium Responses of Isolated Melanopsin-Expressing Retinal Ganglion Cells [PDF]
The Journal of Neuroscience, 2007 A small number (<2%) of mammalian retinal ganglion cells express the photopigment melanopsin and are intrinsically photosensitive (ipRGCs). Light depolarizes ipRGCs and increases intracellular calcium levels ([Ca2+]i) but the signaling cascades underlying these responses have yet to be elucidated.
Hartwick, Andrew T. E. +7 more
openaire +2 more sources