Results 71 to 80 of about 3,657 (172)

Targeted destruction of photosensitive retinal ganglion cells with a saporin conjugate alters the effects of light on mouse circadian rhythms.

PLoS ONE, 2008
Non-image related responses to light, such as the synchronization of circadian rhythms to the day/night cycle, are mediated by classical rod/cone photoreceptors and by a small subset of retinal ganglion cells that are intrinsically photosensitive ...
Didem Göz, Keith Studholme, Douglas A Lappi, Mark D Rollag, Ignacio Provencio, Lawrence P Morin   +5 more
doaj   +1 more source

The organization of melanopsin-immunoreactive cells in microbat retina.

PLoS ONE, 2018
Intrinsically photosensitive retinal ganglion cells (ipRGCs) respond to light and play roles in non-image forming vision, such as circadian rhythms, pupil responses, and sleep regulation, or image forming vision, such as processing visual information and
Mi-Jin Jeong, Hang-Gu Kim, Chang-Jin Jeon   +2 more
doaj   +1 more source

Cross‐Sectional and Longitudinal Associations of the Pupillary Light Response with Mild Cognitive Impairment

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Pupillary light response (PLR) alterations have been observed in individuals with Alzheimer's disease and related dementias (ADRD). Little is known about the predictive utility of the PLR as a biomarker for ADRD or general cognitive decline.
Matthew S. Panizzon, Eric L. Granholm, Kristine C Dell, Francesca Lopez, Chandra A. Reynolds, Carol E. Franz, William S. Kremen, Jeremy A. Elman, The Vietnam Era Twin Study of Aging   +8 more
wiley   +1 more source

Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells.

PLoS ONE, 2015
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are involved in circadian and other non-image forming visual responses. An open question is whether the activity of these neurons may also be under the regulation mediated by the neurohormone ...
Wen-Long Sheng, Wei-Yi Chen, Xiong-Li Yang, Yong-Mei Zhong, Shi-Jun Weng   +4 more
doaj   +1 more source

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

Annals of Neurology, Volume 98, Issue 6, Page 1178-1195, December 2025.
[Color figure can be viewed at www.annalsofneurology.org] Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and ...
Nico J. Diederich, Martin Brüne, John S. Allen, Nicole Bender, Emiliano Bruner, Jean‐Pierre Changeux, Corrado Cali, Olga Dolgova, Anne Grünewald, Geneviève Konopka, Peng Jin, Roger Lemon, Gilberto Levy, Pierre Magistretti, Markus J. Rantala, Kathleen S. Rockland, Roger Sullivan, Annie Swanepoel, Toshiki Uchihara, Katrin Amunts, Christopher G. Goetz   +20 more
wiley   +1 more source

Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract Recent studies have highlighted retinal optical coherence tomography (OCT) imaging as a promising biomarker for the early detection of Alzheimer's disease (AD). This review connects AD brain pathology – particularly amyloid beta (Aβ), tau, and vascular changes – with corresponding retinal changes.
M. Amin Banihashemi, Saffire H. Krance, Patrick Xiang Ji, Morgan Koo, Julie Ottoy, Richard H. Swartz, Peter J. Kertes, Christopher Hudson, Maged Goubran, Sandra E. Black   +9 more
wiley   +1 more source

Circadian rhythm dysfunction in glaucoma: A hypothesis

Journal of Circadian Rhythms, 2008
The absence of circadian zeitgebers in the social environment causes circadian misalignment, which is often associated with sleep disturbances. Circadian misalignment, defined as a mismatch between the sleep-wake cycle and the timing of the circadian ...
Jean-Louis Girardin, Zizi Ferdinand, Lazzaro Douglas R, Wolintz Arthur H   +3 more
doaj   +1 more source

Abnormal Sleep in Chronic Inflammatory Demyelinating Polyneuropathy

European Journal of Neurology, Volume 32, Issue 11, November 2025.
Beyond subjectively reduced sleep quality, actigraphic data show that persons with chronic inflammatory demyelinating polyneuropathy (CIDP) have a lowered sleep efficacy and experience increased nocturnal arousals. This suggests that sleep disturbance is a genuine aspect of CIDP adding to the underrecognized problem of non‐sensorimotor symptoms in this
Oliver L. Steiner, Claudia Angela, Fabian Klostermann   +2 more
wiley   +1 more source

Mouse ganglion-cell photoreceptors are driven by the most sensitive rod pathway and by both types of cones.

PLoS ONE, 2013
Intrinsically photosensitive retinal ganglion cells (iprgcs) are depolarized by light by two mechanisms: directly, through activation of their photopigment melanopsin; and indirectly through synaptic circuits driven by rods and cones. To learn more about
Shijun Weng, Maureen E Estevez, David M Berson   +2 more
doaj   +1 more source

Distribution of melanopsin positive neurons in pigmented and albino mice: Evidence for melanopsin interneurons in the mouse retina

Frontiers in Neuroanatomy, 2014
Here we have studied the population of intrinsically photosensitive retinal ganglion cells (ipRGCs) in adult pigmented and albino mice. Our data show that although pigmented (C57Bl/6) and albino (Swiss) mice have a similar total number of ipRGCs, their ...
Francisco Javier Valiente-Soriano, Diego eGarcía-Ayuso, Arturo eOrtín-Martínez, Manuel eJiménez-López, Caridad eGalindo-Romero, María Paz Villegas-Pérez, Marta eAgudo-Barriuso, Anthony Alexander Vugler, Manuel eVidal-Sanz   +8 more
doaj   +1 more source