Results 21 to 30 of about 3,657 (172)
Signalling by melanopsin (OPN4) expressing photosensitive retinal ganglion cells [PDF]
Eye, 2016 Over the past two decades there have been significant advances in our understanding of both the anatomy and function of the melanopsin system. It has become clear that rather than acting as a simple irradiance detector the melanopsin system is in fact far more complicated.
S, Hughes +5 more
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Acta Neuropathologica Communications, 2018 Parkinson’s disease (PD) patients often suffer from non-motor symptoms like sleep dysregulation, mood disturbances or circadian rhythms dysfunction. The melanopsin-containing retinal ganglion cells are involved in the control and regulation of these ...
Isabel Ortuño-Lizarán +6 more
doaj +1 more source
Cell Reports, 2019 Summary: Light influences various behaviors and physiological processes that occur outside of our conscious perception, including circadian photoentrainment, sleep, and even learning and mood.
Seul Ki Lee +2 more
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The development of melanopsin‐containing retinal ganglion cells in mice with early retinal degeneration [PDF]
European Journal of Neuroscience, 2009 AbstractIn mammals, the neuronal pathways by which rod and cone photoreceptors mediate vision have been well documented. The roles that classical photoreceptors play in photoentrainment, however, have been less clear. In mammals, intrinsically photosensitive retinal ganglion cells (ipRGCs) that express the photopigment melanopsin project directly to ...
Ruggiero, Linda +3 more
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Melanopsin, the photopigment of intrinsically photosensitive retinal ganglion cells [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractMelanopsin (gene symbol: Opn4) is the G protein‐coupled photopigment that confers photosensitivity upon intrinsically photosensitive retinal ganglion cells (ipRGCs). ipRGCs are the third class of retinal photoreceptor in mammals, complementing the two previously identified classes, the rods and cones.
Ignacio Provencio, Daniel M. Warthen
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PLoS ONE, 2014 Mammals contain 1 melanopsin (Opn4) gene that is expressed in a subset of retinal ganglion cells to serve as a photopigment involved in non-image-forming vision such as photoentrainment of circadian rhythms.
Lanfang Sun +6 more
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Melanopsin-expressing retinal ganglion cells in aging and disease.
Histology and histopathology, 2019 Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary light reflex, masking response, light-regulated melatonin secretion, and modulation of the sleep/wake cycle. There
Esquiva, Gema, Hannibal, Jens
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Melanopsin-Positive Intrinsically Photosensitive Retinal Ganglion Cells: From Form to Function [PDF]
The Journal of Neuroscience, 2011 Melanopsin imparts an intrinsic photosensitivity to a subclass of retinal ganglion cells (ipRGCs). Generally thought of as irradiance detectors, ipRGCs target numerous brain regions involved in non-image-forming vision. ipRGCs integrate their intrinsic, melanopsin-mediated light information with rod/cone signals relayed via synaptic connections to ...
Schmidt, Tiffany M. +5 more
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Melanopsin mediates retrograde visual signaling in the retina.
PLoS ONE, 2012 The canonical flow of visual signals proceeds from outer to inner retina (photoreceptors → bipolar cells → ganglion cells). However, melanopsin-expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic ...
Dao-Qi Zhang +4 more
doaj +1 more source
Melanopsin‐Expressing Intrinsically Photosensitive Retinal Ganglion Cells in Retinal Disease
Optometry and Vision Science, 2014 ABSTRACT Melanopsin‐containing intrinsically photosensitive retinal ganglion cells (ipRGCs) are a class of photoreceptors with established roles in non–image‐forming processes. Their contributions to image‐forming vision may include the estimation of brightness. Animal models have been central
Feigl, Beatrix, Zele, Andrew J.
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