Results 1 to 10 of about 3,657 (172)

Synaptic Specializations of Melanopsin-Retinal Ganglion Cells in Multiple Brain Regions Revealed by Genetic Label for Light and Electron Microscopy [PDF]

Cell Reports, 2019
Summary: The form and synaptic fine structure of melanopsin-expressing retinal ganglion cells, also called intrinsically photosensitive retinal ganglion cells (ipRGCs), were determined using a new membrane-targeted version of a genetic probe for ...
Keun-Young Kim, Luis C. Rios, Hiep Le, Alex J. Perez, Sébastien Phan, Eric A. Bushong, Thomas J. Deerinck, Yu Hsin Liu, Maya A. Ellisman, Varda Lev-Ram, Suyeon Ju, Sneha A. Panda, Sanghee Yoon, Masatoshi Hirayama, Ludovic S. Mure, Megumi Hatori, Mark H. Ellisman, Satchidananda Panda   +17 more
doaj   +2 more sources

Amplifying and ameliorating light avoidance in mice with photoreceptor targeting and calcitonin gene-related peptide sensitization. [PDF]

Headache
Abstract Objective The aim of this study was to determine the photoreceptor basis of light avoidance in mice and assess the effect of CGRP sensitization on this behavior. Background Prior studies have suggested that photophobia is mediated by a subset of retinal ganglion cells (RGCs) that contain melanopsin, making them intrinsically photosensitive ...
Kaiser EA, Cavanah A, Aguirre GK, Jensen FE.   +3 more
europepmc   +2 more sources

Light, Sound, and Melatonin: Investigating Multisensory Pathways for Visual Restoration [PDF]

Medicina
Multisensory integration is fundamental for coherent perception and interaction with the environment. While cortical mechanisms of multisensory convergence are well studied, emerging evidence implicates specialized retinal ganglion cells—particularly ...
Dario Rusciano
doaj   +2 more sources

Melanopsin-mediated image statistics from natural and human-made environments [PDF]

Scientific Reports
Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) play a critical role in regulating physiological and behavioral responses to light.
Pablo A. Barrionuevo, Francisco Diaz-Barrancas   +1 more
doaj   +2 more sources

The Roles of Rods, Cones, and Melanopsin in Photoresponses of M4 Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) and Optokinetic Visual Behavior

Frontiers in Cellular Neuroscience, 2018
Intrinsically photosensitive retinal ganglion cells (ipRGCs) mediate not only image-forming vision like other ganglion cells, but also non-image-forming physiological responses to light such as pupil constriction and circadian photoentrainment.
Melanie M. Schroeder, Krystal R. Harrison, Krystal R. Harrison, Elizabeth R. Jaeckel, Hunter N. Berger, Xiwu Zhao, Michael P. Flannery, Emma C. St. Pierre, Nancy Pateqi, Agnieszka Jachimska, Andrew P. Chervenak, Kwoon Y. Wong, Kwoon Y. Wong   +12 more
doaj   +3 more sources

Melanopsin Retinal Ganglion Cells Regulate Cone Photoreceptor Lamination in the Mouse Retina. [PDF]

Cell Rep, 2018
Tufford AR, Onyak JR, Sondereker KB, Lucas JA, Earley AM, Mattar P, Hattar S, Schmidt TM, Renna JM, Cayouette M.   +9 more
europepmc   +2 more sources

Melanopic stimulation does not alter psychophysical threshold sensitivity for luminance flicker

Scientific Reports, 2021
In addition to the rod and cone photoreceptors the retina contains intrinsically photosensitive retinal ganglion cells (ipRGCs). These cells express the photopigment melanopsin and are known to be involved in reflexive visual functions such as pupil ...
Joris Vincent, Edda B. Haggerty, David H. Brainard, Geoffrey K. Aguirre   +3 more
doaj   +1 more source

Dopamine modulates the retinal clock through melanopsin-dependent regulation of cholinergic waves during development

BMC Biology, 2023
Background The mammalian retina contains an autonomous circadian clock that controls various aspects of retinal physiology and function, including dopamine (DA) release by amacrine cells. This neurotransmitter plays a critical role in retina development,
Chaimaa Kinane, Hugo Calligaro, Antonin Jandot, Christine Coutanson, Nasser Haddjeri, Mohamed Bennis, Ouria Dkhissi-Benyahya   +6 more
doaj   +1 more source

The multistable melanopsins of mammals

Frontiers in Ophthalmology, 2023
Melanopsin is a light-activated G protein coupled receptor that is expressed widely across phylogeny. In mammals, melanopsin is found in intrinsically photosensitive retinal ganglion cells (ipRGCs), which are especially important for “non-image” visual ...
Alan J. Emanuel, Michael Tri H. Do
doaj   +1 more source

Melanopsin Driven Light Responses Across a Large Fraction of Retinal Ganglion Cells in a Dystrophic Retina

Frontiers in Neuroscience, 2020
Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin and project to central targets, allowing them to contribute to both image-forming and non-image forming vision.
Cyril G. Eleftheriou, Phillip Wright, Annette E. Allen, Daniel Elijah, Franck P. Martial, Robert J. Lucas   +5 more
doaj   +1 more source