Results 11 to 20 of about 3,657 (172)

Multimodal investigation of melanopsin retinal ganglion cells in Alzheimer's disease. [PDF]

Ann Clin Transl Neurol, 2023
AbstractObjectiveIn Alzheimer's disease (AD), the presence of circadian dysfunction is well‐known and may occur early in the disease course. The melanopsin retinal ganglion cell (mRGC) system may play a relevant role in contributing to circadian dysfunction.
La Morgia C, Mitolo M, Romagnoli M, Stanzani Maserati M, Evangelisti S, De Matteis M, Capellari S, Bianchini C, Testa C, Vandewalle G, Santoro A, Carbonelli M, D'Agati P, Filardi M, Avanzini P, Barboni P, Zenesini C, Baccari F, Liguori R, Tonon C, Lodi R, Carelli V.   +21 more
europepmc   +6 more sources

Melanopsin ganglion cells are the most resistant retinal ganglion cell type to axonal injury in the rat retina.

PLoS ONE, 2014
We report that the most common retinal ganglion cell type that remains after optic nerve transection is the M1 melanopsin ganglion cell. M1 ganglion cells are members of the intrinsically photosensitive retinal ganglion cell population that mediates non ...
Luis Pérez de Sevilla Müller, Allison Sargoy, Allen R Rodriguez, Nicholas C Brecha   +3 more
doaj   +3 more sources

Mood, the Circadian System, and Melanopsin Retinal Ganglion Cells. [PDF]

Annu Rev Neurosci, 2017
The discovery of a third type of photoreceptors in the mammalian retina, intrinsically photosensitive retinal ganglion cells (ipRGCs), has had a revolutionary impact on chronobiology. We can now properly account for numerous non-vision-related functions of light, including its effect on the circadian system.
Lazzerini Ospri L, Prusky G, Hattar S.
europepmc   +4 more sources

Melanopsin Retinal Ganglion Cells and Pupil: Clinical Implications for Neuro-Ophthalmology. [PDF]

Front Neurol, 2018
Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs that mediate many relevant non-image forming functions of the eye, including the pupillary light reflex, through the projections to the olivary pretectal nucleus. In particular, the post-illumination pupil response (PIPR), as evaluated by chromatic pupillometry, can be used
La Morgia C, Carelli V, Carbonelli M.
europepmc   +6 more sources

Melanopsin retinal ganglion cell loss in Alzheimer disease [PDF]

Annals of Neurology, 2015
ObjectiveMelanopsin retinal ganglion cells (mRGCs) are photoreceptors driving circadian photoentrainment, and circadian dysfunction characterizes Alzheimer disease (AD). We investigated mRGCs in AD, hypothesizing that they contribute to circadian dysfunction.MethodsWe assessed retinal nerve fiber layer (RNFL) thickness by optical coherence tomography ...
LA MORGIA, CHIARA, Ross Cisneros, Fred N, Koronyo, Yosef, Hannibal, Jens, GALLASSI, ROBERTO, Cantalupo, Gaetano, SAMBATI, LUISA, Pan, Billy X, Tozer, Kevin R, Barboni, Piero, PROVINI, FEDERICA, Avanzini, Pietro, Carbonelli, Michele, Pelosi, Annalisa, Chui, Helena, LIGUORI, ROCCO, BARUZZI, AGOSTINO, Koronyo Hamaoui, Maya, Sadun, Alfredo A, CARELLI, VALERIO   +19 more
openaire   +7 more sources

Photon capture and signalling by melanopsin retinal ganglion cells [PDF]

Nature, 2008
A subset of retinal ganglion cells has recently been discovered to be intrinsically photosensitive, with melanopsin as the pigment. These cells project primarily to brain centres for non-image-forming visual functions such as the pupillary light reflex and circadian photoentrainment.
Do, Michael Tri H., Kang, Shin H., Xue, Tian, Zhong, Haining, Liao, Hsi-Wen, Bergles, Dwight E., Yau, King-Wai   +6 more
openaire   +2 more sources

Intrinsically Photosensitive (Melanopsin) Retinal Ganglion Cell Function in Glaucoma [PDF]

Investigative Opthalmology & Visual Science, 2011
To determine whether glaucoma alters intrinsically photosensitive retinal ganglion cell (ipRGC) function.Forty-one patients (25 with glaucoma and 16 healthy age-matched control participants) were tested. Intrinsically photosensitive retinal ganglion cell function was directly measured by the sustained, postillumination pupil response (PIPR).
Feigl, Beatrix, Mattes, Dietmar, Thomas, Ravi, Zele, Andrew J.   +3 more
openaire   +5 more sources

A Role for Melanopsin in Alpha Retinal Ganglion Cells and Contrast Detection [PDF]

Neuron, 2014
Distinct subclasses of retinal ganglion cells (RGCs) mediate vision and nonimage-forming functions such as circadian photoentrainment. This distinction stems from studies that ablated melanopsin-expressing intrinsically photosensitive RGCs (ipRGCs) and showed deficits in nonimage-forming behaviors, but not image vision.
Schmidt, Tiffany M., Alam, Nazia M., Chen, Shan, Kofuji, Paulo, Li, Wei, Prusky, Glen T., Hattar, Samer   +6 more
openaire   +2 more sources

Brain responses to violet, blue, and green monochromatic light exposures in humans: prominent role of blue light and the brainstem. [PDF]

PLoS ONE, 2007
Relatively long duration retinal light exposure elicits nonvisual responses in humans, including modulation of alertness and cognition. These responses are thought to be mediated in part by melanopsin-expressing retinal ganglion cells which are more ...
Gilles Vandewalle, Christina Schmidt, Geneviève Albouy, Virginie Sterpenich, Annabelle Darsaud, Géraldine Rauchs, Pierre-Yves Berken, Evelyne Balteau, Christian Degueldre, André Luxen, Pierre Maquet, Derk-Jan Dijk   +11 more
doaj   +1 more source

Melanopsin Cell Dysfunction is Involved in Sleep Disruption in Parkinson’s Disease

Journal of Parkinson’s Disease, 2020
Background: Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) signal the environmental light to mediate circadian photoentrainment and sleep-wake cycles.
Beatrix Feigl, Sunila Dumpala, Graham K. Kerr, Andrew J. Zele   +3 more
doaj   +1 more source