Results 31 to 40 of about 3,657 (172)

Melanopsin retinal ganglion cells are resistant to neurodegeneration in mitochondrial optic neuropathies [PDF]

Brain, 2010
Mitochondrial optic neuropathies, that is, Leber hereditary optic neuropathy and dominant optic atrophy, selectively affect retinal ganglion cells, causing visual loss with relatively preserved pupillary light reflex. The mammalian eye contains a light detection system based on a subset of retinal ganglion cells containing the photopigment melanopsin ...
LA MORGIA, CHIARA, Ross Cisneros F. N., Sadun A. A., Hannibal J., Munarini A., Mantovani V., Barboni P., Cantalupo G., Tozer K. R., Sancisi E., Salomao S. R., Moraes M. N., Moraes Filho M. N., Heegaard S., Milea D., Kjer P., MONTAGNA, PASQUALE, CARELLI, VALERIO   +17 more
openaire   +4 more sources

Morphology and mosaics of melanopsin‐expressing retinal ganglion cell types in mice [PDF]

Journal of Comparative Neurology, 2010
AbstractMelanopsin is the photopigment of intrinsically photosensitive retinal ganglion cells (ipRGCs). Melanopsin immunoreactivity reveals two dendritic plexuses within the inner plexiform layer (IPL) and morphologically heterogeneous retinal ganglion cells.
David M, Berson, Ana Maria, Castrucci, Ignacio, Provencio   +2 more
openaire   +3 more sources

Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies

npj Aging and Mechanisms of Disease, 2017
Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and non-image forming adaptation of physiology and behavior to light.
Megumi Hatori, Claude Gronfier, Russell N. Van Gelder, Paul S. Bernstein, Josep Carreras, Satchidananda Panda, Frederick Marks, David Sliney, Charles E. Hunt, Tsuyoshi Hirota, Toshiharu Furukawa, Kazuo Tsubota   +11 more
doaj   +1 more source

Adult Expression of Tbr2 Is Required for the Maintenance but Not Survival of Intrinsically Photosensitive Retinal Ganglion Cells

Frontiers in Cellular Neuroscience, 2022
Retinal ganglion cells expressing the photopigment melanopsin are intrinsically photosensitive (ipRGCs). ipRGCs regulate subconscious non-image-forming behaviors such as circadian rhythms, pupil dilation, and light-mediated mood.
Sadaf Abed, Andreea Reilly, Sebastian J. Arnold, David A. Feldheim   +3 more
doaj   +1 more source

Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity [PDF]

Science, 2002
The primary circadian pacemaker, in the suprachiasmatic nucleus (SCN) of the mammalian brain, is photoentrained by light signals from the eyes through the retinohypothalamic tract. Retinal rod and cone cells are not required for photoentrainment. Recent evidence suggests that the entraining photoreceptors are retinal ganglion cells (RGCs) that project ...
S, Hattar, H W, Liao, M, Takao, D M, Berson, K W, Yau   +4 more
openaire   +2 more sources

Melanopsin expression is an indicator of the well-being of melanopsin-expressing retinal ganglion cells but not of their viability

Neural Regeneration Research, 2016
Light is an electromagnetic stimulus that in mammals is sensed by specialized neurons in the retina. The physiological response to light encompasses two fundamental and different functional outputs: image-forming and non-image forming. The image-forming response is classically known as vision, while the non-image forming responses include the circadian
Agudo-Barriuso, Marta, Nadal-Nicolás, Francisco M, Madeira, Maria H., Rovere, Giuseppe, Vidal-Villegas, Beatriz, Vidal-Sanz, Manuel   +5 more
openaire   +4 more sources

Form vision from melanopsin in humans

Nature Communications, 2019
The perception of spatial patterns (form vision) is thought to rely on rod and cone cells in the retina. Here, the authors show that a third kind of retinal cell, melanopsin-expressing ganglion cells, can also detect form in humans, under particular ...
Annette E. Allen, Franck P. Martial, Robert J. Lucas   +2 more
doaj   +1 more source

Melanopsin-expressing retinal ganglion cells: implications for human diseases

Vision Research, 2011
In the last decade, there was the seminal discovery of melanopsin-expressing retinal ganglion cells (mRGCs) as a new class of photoreceptors that subserve the photoentrainment of circadian rhythms and other non-image forming functions of the eye. Since then, there has been a growing research interest on these cells, mainly focused on animal models ...
LA MORGIA, CHIARA, Ross Cisneros F. N., Hannibal J., MONTAGNA, PASQUALE, Sadun A. A., CARELLI, VALERIO   +5 more
openaire   +3 more sources

Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond

Frontiers in Neurology, 2017
There is increasing awareness on the role played by circadian rhythm abnormalities in neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Chiara La Morgia, Chiara La Morgia, Fred N. Ross-Cisneros, Alfredo A. Sadun, Alfredo A. Sadun, Valerio Carelli, Valerio Carelli   +6 more
doaj   +1 more source

Melanopsin-Encoded Response Properties of Intrinsically Photosensitive Retinal Ganglion Cells [PDF]

Neuron, 2016
Melanopsin photopigment expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs) plays a crucial role in the adaptation of mammals to their ambient light environment through both image-forming and non-image-forming visual responses. The ipRGCs are structurally and functionally distinct from classical rod/cone photoreceptors and have ...
Ludovic S, Mure, Megumi, Hatori, Quansheng, Zhu, James, Demas, Irene M, Kim, Surendra K, Nayak, Satchidananda, Panda   +6 more
openaire   +2 more sources