Results 71 to 80 of about 7,378 (211)

Connexin30.2:In vitro interaction with connexin36 in hela cells and expression in AII amacrine cells and intrinsically photosensitive ganglion cells in the mouse retina [PDF]

, 2016
Electrical coupling via gap junctions is an abundant phenomenon in the mammalian retina and occurs in all major cell types. Gap junction channels are assembled from different connexin subunits, and the connexin composition of the channel confers specific
Anderson, Arndt Meyer, Birthe Dorgau, Bolte, Brüggen, Coronel-Cruz, Deans, Dedek, Dedek, DeVries, Dorgau, Feigenspan, Feigenspan, Gemel, Güldenagel, Güler, Han, Hartveit, Haverkamp, Helbig, Helena Greb, Hilgen, Hombach, Jasmin Segelken, Jeon, Karin Dedek, Kim, Kothmann, Kothmann, Kranz, Kreuzberg, Kreuzberg, Kreuzberg, Kumar, Lee, Lee, Li, Manasson, Maxeiner, Meyer, Mills, Müller, Müller, Pan, Pang, Pang, Reifler, Reto Weiler, Rice, Sand, Schindelin, Schubert, Sekaran, Sheriar G. Hormuzdi, Stephan Tetenborg, Sun, Söhl, Teubner, Ulrike Janssen-Bienhold, Vaney, Veruki, Völgyi, Völgyi   +62 more
core   +2 more sources

Broad Epigenetic Shifts in the Aging Drosophila Retina Contribute to Its Altered Diurnal Rhythmic Transcriptome

Aging Cell, Volume 25, Issue 2, February 2026.
As flies age, their photoreceptor transcriptome is extensively reprogrammed, with about 40% of genes undergoing rhythmic expression changes. These transcriptional changes are accompanied by altered RNA Polymerase II occupancy, chromatin accessibility, and H3K4 methylation, without major changes to the occupancy of the core clock transcription factors ...
Sarah E. McGovern, Gaoya Meng, Makayla N. Marlin, Sophia A. Pruitt, Vikki M. Weake   +4 more
wiley   +1 more source

Light-induced fos expression in intrinsically photosensitive retinal ganglion cells in melanopsin knockout (opn4) mice.

PLoS ONE, 2009
Retinal ganglion cells that express the photopigment melanopsin are intrinsically photosensitive (ipRGCs) and exhibit robust synaptically driven ON-responses to light, yet they will continue to depolarize in response to light when all synaptic input from
Gary E Pickard, Scott B Baver, Malcolm D Ogilvie, Patricia J Sollars   +3 more
doaj   +1 more source

Medical management of hereditary optic neuropathies. [PDF]

, 2014
Hereditary optic neuropathies are diseases affecting the optic nerve. The most common are mitochondrial hereditary optic neuropathies, i.e., the maternally inherited Leber's hereditary optic neuropathy (LHON) and dominant optic atrophy (DOA).
Barboni, Piero, Carbonelli, Michele, Carelli, Valerio, La Morgia, Chiara, Sadun, Alfredo Arrigo   +4 more
core   +1 more source

Melanopsin Stimulation Modulates Blackness Induction

Color Research &Application, Volume 51, Issue 1, January/February 2026.
Spectral power distributions of (A) the surround and (B) the center stimuli. The stimulus intensity to melanopsin cells of the surround was modulated from 0.51 to 1.21 (#1; 0.51, #2; 0.65, #3; 0.78, #4; 0.93, #5; 1.09, #6; 1.21, #7; 0.51, #8; 0.67, #9; 0.95, #10; 1.21) in the melanopic/photopic ratio (M/P ratio) under both the 700 cd/m2 and 375 cd/m2 ...
Masahiko Yamakawa, Katsunori Okajima, John S. Werner   +2 more
wiley   +1 more source

A Role for Melanopsin in Alpha Retinal Ganglion Cells and Contrast Detection [PDF]

Neuron, 2014
Distinct subclasses of retinal ganglion cells (RGCs) mediate vision and nonimage-forming functions such as circadian photoentrainment. This distinction stems from studies that ablated melanopsin-expressing intrinsically photosensitive RGCs (ipRGCs) and showed deficits in nonimage-forming behaviors, but not image vision.
Schmidt, Tiffany M., Alam, Nazia M., Chen, Shan, Kofuji, Paulo, Li, Wei, Prusky, Glen T., Hattar, Samer   +6 more
openaire   +2 more sources

Melanopsin activates divergent phototransduction pathways in intrinsically photosensitive retinal ganglion cell subtypes

eLife, 2023
Melanopsin signaling within intrinsically photosensitive retinal ganglion cell (ipRGC) subtypes impacts a broad range of behaviors from circadian photoentrainment to conscious visual perception. Yet, how melanopsin phototransduction within M1-M6 ipRGC subtypes impacts cellular signaling to drive diverse behaviors is still largely unresolved.
Ely Contreras, Jacob D Bhoi, Takuma Sonoda, Lutz Birnbaumer, Tiffany M Schmidt   +4 more
openaire   +3 more sources

NMDA Receptors Contribute to Retrograde Synaptic Transmission from Ganglion Cell Photoreceptors to Dopaminergic Amacrine Cells

Frontiers in Cellular Neuroscience, 2017
Recently, a line of evidence has demonstrated that the vertebrate retina possesses a novel retrograde signaling pathway. In this pathway, phototransduction is initiated by the photopigment melanopsin, which is expressed in a small population of retinal ...
Lei-Lei Liu, Nathan J. Spix, Dao-Qi Zhang   +2 more
doaj   +1 more source

Contribution of human melanopsin retinal ganglion cells to steady-state pupil responses [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2010
The recent discovery of melanopsin-containing retinal ganglion cells (mRGCs) has led to a fundamental reassessment of non-image forming processing, such as circadian photoentrainment and the pupillary light reflex. In the conventional view of retinal physiology, rods and cones were assumed to be the only photoreceptors in the eye and were, therefore ...
Sei-ichi, Tsujimura, Kazuhiko, Ukai, Daisuke, Ohama, Atsuo, Nuruki, Kazutomo, Yunokuchi   +4 more
openaire   +2 more sources

A systematic comparison of optogenetic approaches to visual restoration

Molecular Therapy: Methods & Clinical Development, 2022
During inherited retinal degenerations (IRDs), vision is lost due to photoreceptor cell death; however, a range of optogenetic tools have been shown to restore light responses in animal models. Restored response characteristics vary between tools and the
Michael J. Gilhooley, Moritz Lindner, Teele Palumaa, Steven Hughes, Stuart N. Peirson, Mark W. Hankins   +5 more
doaj   +1 more source