Results 141 to 150 of about 64,266 (267)

Inhibition of late sodium current prevents pathological hyperactivation of calcium/calmodulin‐dependent protein kinase IIδ in a murine model of acute doxorubicin‐related cardiotoxicity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder, Anna‐Maria Pfützenreuter, Lea Maria Funke, Maria Johanna Baier, Daniel Tarnowski, Laura Stengel, Lars Siegfried Maier, Can Martin Sag   +7 more
wiley   +1 more source

Oxidative Stress and Blood Parameters During Shearing in Sheep Treated with Melatonin. [PDF]

Animals (Basel)
Carcangiu V, Luridiana S, Cocco R, Trimasse O, Bennaghmouch I, Ouadday M, Mura MC.   +6 more
europepmc   +1 more source

Collagen Type VI Alpha 1 as a Regulator of Redox Homeostasis in Antioxidant‐Enhanced Osteogenesis of Dental Stem Cells

Cell Proliferation, EarlyView.
Under physiological conditions, NAC activates the PI3K‐AKT‐COL6A1 axis to sustain redox balance and enhance osteogenesis. COL6A1 deficiency, however, compromises this axis, inducing oxidative stress and impairing NAC's osteogenic efficacy. ABSTRACT Alveolar bone injury represents a prevalent clinical challenge in dentistry, for which stem cell‐based ...
Zhaosong Meng, Jiacheng Liu, Yue Zhang, Ruimeng Yang, Jingyi Zhang, Haosun Yang, Zheng Wang, Ran Wei, Zhe Li, Shuling Guo, Lizhi Hu, Lei Sui   +11 more
wiley   +1 more source

Melatonin suppresses abnormal hyperexcitability of hippocampal CA1 neurons in early-stage oxygen-glucose deprivation. [PDF]

Front Pharmacol
Cui Y, Wang Q, Liu C, Zhou H.
europepmc   +1 more source

Sleep health of adults with cerebral palsy: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
Although many people with cerebral palsy (CP) are adults, most sleep research in CP focuses on children. As poor sleep can affect pain, mood, energy, daily functioning, and quality of life we reviewed what is currently known about the sleep health of adults with CP. We searched three major research databases (MEDLINE, Embase, and CINAHL) up to February
Deepika Nagabhushan, Caleb Kim, Daniel G. Whitney, Rita Ayyangar, Angeline Bowman, Sonia Sharma, Maxwell S. Barnish, Daniel Whibley   +7 more
wiley   +1 more source

Phytomelatonin as a key regulator of drought stress adaptation: signaling networks, microbial interactions, and biotechnological potential. [PDF]

Front Plant Sci
Dubey N, Shree S, Prakash S, Subramanian V, H P S, Kumar S.   +5 more
europepmc   +1 more source

Sleep disturbances in children with cerebral palsy, their siblings, and parents: A qualitative descriptive study

Developmental Medicine &Child Neurology, EarlyView.
Children with cerebral palsy who experienced clinically significant sleep disturbances, their parents, and their siblings, were interviewed to understand the impact of sleep disturbance on the whole family. Six themes were identified, demonstrating the need for tailored, multidisciplinary, holistic sleep assessment and intervention, and family support.
Mary‐Elaine McCavert, Oliver Perra, Karen McConnell, Claire Kerr   +3 more
wiley   +1 more source

Melatonin Targets Mitochondrial Redox Homeostasis: Optimizing the Intracellular Microenvironment. [PDF]

Int J Mol Sci
Reiter RJ, Sharma R, Loh D, Chuffa LGA, Bai Y, Zuccari DAPC, Galano A, Manucha W.   +7 more
europepmc   +1 more source

Biochemical profiling and symptomatology of androgen deficiency in males with cluster headache: A prospective case–control study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Cluster headache (CH) has historically been considered a male‐dominated disorder, suggesting a role for androgens in its pathophysiology. We aimed to evaluate hormone profiles and symptoms of androgen deficiency in CH.
Willemijn C. Naber, Roemer B. Brandt, Mariël Leon Morales‐Grooters, Ronald van der Wal, Sjoerd A. A. van den Berg, Jelle J. Goeman, Antoinette Maassen van den Brink, Rolf Fronczek   +7 more
wiley   +1 more source

Melatonin and cardiovascular risk: an NHANES reality check after recent heart failure concerns. [PDF]

Open Heart
Khan B, Lima BB.
europepmc   +1 more source