Results 121 to 130 of about 108,758 (309)
Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents
Advanced Intelligent Discovery, EarlyView.This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer +3 more
wiley +1 more source
Design and structure-activity relationships of subtype selective melatonin receptor ligands.
, 2008 Convegno - FASEB Summer Research Conferences Melatonin Receptors: Actions and ...
GOBBI G. +7 more
core +1 more source
Relationship between post-awakening salivary cortisol and melatonin secretion in healthy participants [PDF]
, 2016 We report the relationship between patterns of post-awakening salivary melatonin and cortisol secretion in healthy participants (n=51; mean age 21.6 ±5.0 years).
Thorn, L. +5 more
core +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT ADNP‐related Helsmoortel–Van der Aa syndrome (ADNP‐related HVDAS) is a single gene form of autism spectrum disorder (ASD) caused by pathogenic sequence variants in the activity‐dependent neuroprotective protein (ADNP) gene. In addition to ASD, ADNP‐related HVDAS is associated with a wide range of cognitive, behavioral, and physical health ...
Jarrett Fastman +11 more
wiley +1 more source
Melatonin in Chinese medicinal herbs
, 2003 Melatonin is a highly conserved molecule that not only exists in animals, but also is present in bacteria, unicellular organisms and in plants. Since melatonin is an antioxidant, in plants melatonin was speculated to protect them from intrinsic and ...
Zhang, WB +5 more
core +1 more source
The effects of acute melatonin supplementation on central and peripheral responses in healthy humans during sympathetic stimuli [PDF]
, 2023 There is evidence that melatonin has more functions other than regulating sleeping tendencies such as anti-hypertensive and antioxidant functions, however how melatonin exerts these functions is unknown.
Skillett, Sarah
core
Biallelic PAX6 Variants in an Adult With Severe Microphthalmia and Preserved Intellectual Function
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT PAX6 encodes a dosage‐sensitive transcription factor that is essential for eye development. Heterozygous PAX6 disease is well characterized, but biallelic disease is extremely rare and has been associated with anophthalmia, severe brain malformations, and perinatal lethality.
Karl De Geer +4 more
wiley +1 more source
Morning Plasma Melatonin Differences in Autism: Beyond the Impact of Pineal Gland Volume
Frontiers in Psychiatry, 2019 While low plasma melatonin, a neuro-hormone synthesized in the pineal gland, has been frequently associated with autism, our understanding of the mechanisms behind it have remained unclear.
Anna Maruani +17 more
doaj +1 more source
Effect of Melatonin and Analogues on Corneal Wound Healing: Involvement of Mt2 Melatonin Receptor
, 2015 Purpose: We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing. Methods: New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soaked in n-heptanol on the cornea ...
Alarma Estrany, Pilar +7 more
core +1 more source
Advanced NanoBiomed Research, EarlyView.Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang +12 more
wiley +1 more source