Results 11 to 20 of about 29,812 (167)

Role of melatonin receptors in the effect of estrogen on brain edema, intracranial pressure and expression of aquaporin 4 after traumatic brain injury [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2018
Objective(s): Traumatic brain injury (TBI) is one of the most common causes of death and disability in modern societies. The role of steroids and melatonin is recognized as a neuroprotective factor in traumatic injuries.
Nader Shahrokhi   +4 more
doaj   +1 more source

Assessment of melatonin-alpha adrenergic receptor complexes by molecular docking analysis

open access: yesBrazilian Journal of Biology, 2022
The pineal melatonin (N-acetyl-5-methoxytryptamine) is a molecule associated in a way or another with probably all physiological systems, aiming to fulfil its functional integrative roles in central nervous system activity, sleep and wakefulness cycles ...
V. G. Borges, J. E. Gabriel
doaj   +1 more source

Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

open access: yesRespiratory Research, 2020
Background It is well known that ventilation with high volume or pressure may damage healthy lungs or worsen injured lungs. Melatonin has been reported to be effective in animal models of acute lung injury.
Geng-Chin Wu   +5 more
doaj   +1 more source

Preliminary Evaluation of Human Gingiva as an Extrapineal Site of Melatonin Biosynthesis in States of Periodontal Health and Disease [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2018
Introduction: Melatonin is a pineal gland hormone that plays an important role in periodontal homeostasis. Extra pineal melatonin production has been found to occur in tissues like the ovaries, retina and gastrointestinal tract.
Balaji Thodur Madapusi, Suresh Ranga Rao
doaj   +1 more source

Modulation of human ovarian function by melatonin

open access: yesFrontiers in Bioscience-Elite, 2020
Melatonin, a hormone which is primarily released by the pineal gland, has a wide range of actions in the female reproductive tract. While the melatonin receptor subtype, MT3, has been identified in amphibian animals and birds, in humans and other mammals,
Seema Rai, Hindole Gosh
doaj   +1 more source

Modeling the Heterodimer Interfaces of Melatonin Receptors

open access: yesFrontiers in Cellular Neuroscience, 2021
Melatonin receptors are Class A G protein-coupled receptors (GPCRs) that regulate a plethora of physiological activities in response to the rhythmic secretion of melatonin from the pineal gland.
Lap Hang Tse   +3 more
doaj   +1 more source

Clinical usefulness of melatonin MT1 and MT2 receptor agonists in the treatment of sleep disorders and depression

open access: yesMedycyna Ogólna i Nauki o Zdrowiu, 2022
Introduction and objective Melatonin is the most important compound produced by the pineal gland. Its daily secretion cycle is responsible for the normal rhythm of sleep and wakefulness.
Sara Hmaidan   +3 more
doaj   +1 more source

Melatonin abolished proinflammatory factor expression and antagonized osteoarthritis progression in vivo

open access: yesCell Death and Disease, 2022
Progressive structural changes in osteoarthritis (OA) involve synovial inflammation and angiogenesis, as well as activation of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin (IL)-8, and the angiogenic factor vascular ...
Shan-Chi Liu   +7 more
doaj   +1 more source

Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. [PDF]

open access: yesPLoS ONE, 2016
Melatonin is rhythmically secreted by both the pineal gland and retina in a circadian fashion, with its peak synthesis occurring during the night. Once synthesized, melatonin exerts its effects by binding to two specific G-protein coupled receptors ...
Sharon Owino   +3 more
doaj   +1 more source

Vascular Melatonin Receptors

open access: yesNeurosignals, 1993
High-affinity melatonin receptors are expressed in the tail artery of the rat and arteries forming the circle of Willis of the rat and certain primates. The characteristics of the vascular melatonin receptors seem to be similar to the ones described in the central nervous system.
M, Viswanathan   +2 more
openaire   +2 more sources

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