Results 21 to 30 of about 61,717 (309)

Evaluation of the EVA Descriptor for QSAR Studies: 3. The use of a Genetic Algorithm to Search for Models with Enhanced Predictive Properties (EVA_GA) [PDF]

, 2000
The EVA structural descriptor, based upon calculated fundamental molecular vibrational frequencies, has proved to be an effective descriptor for both QSAR and database similarity calculations.
Turner, D.B., Willett, P.
core   +1 more source

Melatonin abolished proinflammatory factor expression and antagonized osteoarthritis progression in vivo

Cell Death and Disease, 2022
Progressive structural changes in osteoarthritis (OA) involve synovial inflammation and angiogenesis, as well as activation of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin (IL)-8, and the angiogenic factor vascular ...
Shan-Chi Liu, Chun-Hao Tsai, Yu-Han Wang, Chen-Ming Su, Hsi-Chin Wu, Yi-Chin Fong, Shun-Fa Yang, Chih-Hsin Tang   +7 more
doaj   +1 more source

Vascular Melatonin Receptors

Neurosignals, 1993
High-affinity melatonin receptors are expressed in the tail artery of the rat and arteries forming the circle of Willis of the rat and certain primates. The characteristics of the vascular melatonin receptors seem to be similar to the ones described in the central nervous system.
M, Viswanathan, J T, Laitinen, J M, Saavedra   +2 more
openaire   +2 more sources

Circadian regulation of reproduction: From gamete to offspring [PDF]

, 2013
P01326625; Grants: GNT0519315Few challenges are more critical to the survival of a species than reproduction. To ensure reproductive success, myriad aspects of physiology and behaviour need to be tightly orchestrated within the animal, as well as timed ...
Boden, M., Kennaway, D., Varcoe, T.
core   +1 more source

GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals

BMC Evolutionary Biology, 2008
Background The melatonin receptor subfamily contains three members Mel1a, Mel1b and Mel1c, found in all vertebrates except for Mel1c which is found only in fish, Xenopus species and the chicken.
Malpaux Benoit, Pontarotti Pierre, Callebaut Isabelle, Migaud Martine, Levasseur Anthony, Dufourny Laurence, Monget Philippe   +6 more
doaj   +1 more source

Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. [PDF]

PLoS ONE, 2016
Melatonin is rhythmically secreted by both the pineal gland and retina in a circadian fashion, with its peak synthesis occurring during the night. Once synthesized, melatonin exerts its effects by binding to two specific G-protein coupled receptors ...
Sharon Owino, Susana Contreras-Alcantara, Kenkichi Baba, Gianluca Tosini   +3 more
doaj   +1 more source

Melatonin receptor genes

Annals of Medicine, 1998
Melatonin is produced rhythmically by the pineal gland and the retina with increased synthesis during darkness. Pineal melatonin serves as the 'chemical expression of darkness' conveying information on the ambient light-dark cycle into rhythmic bodily functions.
T, Kokkola, J T, Laitinen
openaire   +2 more sources

How to cite curated databases and how to make them citable [PDF]

, 2006
Curated scientific databases such as the IUPHAR database resemble conventional publications such as reference manuals in that they represent the work of a large number of people who both create and revise their contents.
Buneman, Peter
core   +1 more source

Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control [PDF]

, 2008
The pars tuberalis (PT) of the pituitary gland expresses a high density of melatonin (MEL) receptors and is believed to regulate seasonal physiology by decoding changes in nocturnal melatonin secretion.
Alison Downing, Ando, Andrew S. I. Loudon, Ashburner, Bae, Barrett, Bartness, Bechtold, Benoit Malpaux, Bockers, Bockers, Bockmann, Brahimi-Horn, Camon, Carr, Chemineau, Chen, Curlewis, Daphne Mouzaki, Dardente, Dave W. Burt, David Waddington, Draghici, Dupre, Fukuhara, Gerald A. Lincoln, Ghorbel, Graham, Grossmann, Hanon, Hazlerigg, Hazlerigg, Hazlerigg, Hogenesch, Hu, Hu, Johnston, Johnston, Johnston, Julian R. E. Davis, Kel, Kijas, Klosen, Ko, Lamolet, Lee, Lincoln, Lincoln, Lincoln, Lincoln, Malpaux, Merks, Messager, Michan, Morgan, Morgan, Mutoh, Nakao, Naya, Naya, Nilaweera, Oki, Poulin, Reick, Revollo, Richard Talbot, Roepke, Rutter, Samal, Sandrine M. Dupré, Schroeder, Segawa, Stehle, Stirland, Storey, Su, Tobler, Tournier, Wagner, Westfall, Williams, Wittkowski, Yang, Yokoyama   +83 more
core   +2 more sources

Melatonin Modulates the GABAergic Response in Cultured Rat Hippocampal Neurons

Journal of Pharmacological Sciences, 2012
In the present study, we investigated the effect of melatonin on the GABA-induced current (IGABA) and GABAergic miniature inhibitory postsynaptic currents (mIPSCs) in cultured rat hippocampal neurons using the whole-cell patch-clamp technique.
Xin-Ping Cheng, Hao Sun, Zeng-You Ye, Jiang-Ning Zhou   +3 more
doaj   +1 more source