Results 21 to 30 of about 29,812 (167)
GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals
BMC Evolutionary Biology, 2008 Background The melatonin receptor subfamily contains three members Mel1a, Mel1b and Mel1c, found in all vertebrates except for Mel1c which is found only in fish, Xenopus species and the chicken.
Malpaux Benoit +6 more
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Annals of Medicine, 1998 Melatonin is produced rhythmically by the pineal gland and the retina with increased synthesis during darkness. Pineal melatonin serves as the 'chemical expression of darkness' conveying information on the ambient light-dark cycle into rhythmic bodily functions.
T, Kokkola, J T, Laitinen
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Melatonin administration for sleep disorders in traumatic brain injury: A review of the literature
The Journal of the International Society of Physical and Rehabilitation Medicine, 2022 Melatonin is a neurohormone that acts at the suprachiasmatic nucleus to diminish the wake-promoting signal of the circadian clock and induce sleepiness. Exogenous melatonin is available as an over-the-counter supplement to induce sleepiness with 1.3% of ...
Christina Barton, Christopher Falco
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Melatonin Modulates the GABAergic Response in Cultured Rat Hippocampal Neurons
Journal of Pharmacological Sciences, 2012 In the present study, we investigated the effect of melatonin on the GABA-induced current (IGABA) and GABAergic miniature inhibitory postsynaptic currents (mIPSCs) in cultured rat hippocampal neurons using the whole-cell patch-clamp technique.
Xin-Ping Cheng +3 more
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Melatonin, Melatonin Receptors and Melanophores: A Moving Story [PDF]
Pigment Cell Research, 2004 Melatonin (5‐methoxy N‐acetyltryptamine) is a hormone synthesized and released from the pineal gland at night, which acts on specific high affinity G‐protein coupled receptors to regulate various aspects of physiology and behaviour, including circadian and seasonal responses, and some retinal, cardiovascular and immunological functions.
Sugden, D +3 more
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Empowering Melatonin Therapeutics with Drosophila Models
Diseases, 2021 Melatonin functions as a central regulator of cell and organismal function as well as a neurohormone involved in several processes, e.g., the regulation of the circadian rhythm, sleep, aging, oxidative response, and more.
Cassandra Millet-Boureima +5 more
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PLoS ONE, 2016 Aim"Perioceutics" including antimicrobial therapy and host modulatory therapy has emerged as a vital adjunctive treatment of periodontal disease. Melatonin level was significantly reduced in patients with periodontal diseases suggesting melatonin could ...
Wei Zhou +5 more
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Anti-Inflammatory Effects of Melatonin in Rats with Induced Type 2 Diabetes Mellitus
Life, 2022 Introduction: Insulin resistance is associated with a pro-inflammatory state increasing the risk for complications in patients with type 2 diabetes mellitus (T2DM).
Hande Yapislar +6 more
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Frontiers in Neuroscience, 2015 Melatonin receptor gene expression as well as melatonin synthesis and secretion activities were examined in the pineal gland of the grass puffer, which exhibits unique lunar/tidal cycle-synchronized mass spawing: spawning occurs before high tide on the ...
Taro eIkegami +4 more
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Characterization of central melatonin receptors using 125I‐melatonin [PDF]
FEBS Letters, 1986 The binding of 125I‐melatonin, a potent analog of melatonin, to rat brain synaptosomal preparations was investigated. 125I‐melatonin bound with high affinity (K d = 38 nM) to a single class of sites (B max = 81 protein). Kinetic studies indicated that binding was time‐dependent and reversible. Specific 125I‐melatonin binding was inhibited by melatonin,
Laudon, Moshe, Zisapel, Nava
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