Results 51 to 60 of about 29,812 (167)

Melatonin Alleviates BPA-Induced Testicular Apoptosis and Endoplasmic Reticulum Stress

Frontiers in Bioscience-Landmark
Background: The impact of melatonin on bisphenol A (BPA)-induced testicular apoptosis and endoplasmic reticulum (ER) stress was explored. Methods: The mice received BPA (50 mg/kg) by gavage for 30 days while being injected with 20 mg/kg melatonin ...
Qi Qi, Lei Feng, Jingjing Liu, Da Xu, Guoqing Wang, Xiaoyan Pan   +5 more
doaj   +1 more source

Melatonin regulates circadian clock proteins expression in allergic airway inflammation

Heliyon
Asthma demonstrates a strong circadian rhythm with disrupted molecular clock. Melatonin which can directly regulate circadian rhythm has been reported to alleviate asthma, but whether this effect is related to its regulation on circadian clock has not ...
Si-Nuo Guo, Xu-Qin Jiang, Ning Chen, Si-Ming Song, Yu Fang, Qiu-Meng Xie, Guang-He Fei, Hui-Mei Wu   +7 more
doaj   +1 more source

Research on the effects and related mechanisms of geomagnetic storm on depression

Brain Research Bulletin
Objective: Depression has become disabling disease in the world. Geomagnetic storm is closely related to depression behavior, and melatonin is an important factor in the pathogenesis of depression. This study observed the effects of different intensities
Hui Wu, Yuan Yang, Weiyu Chang, Xinli Chen, Shiqi Yang, Min Xu, Keyu Liu, Yu Yun, Liang Dong   +8 more
doaj   +1 more source

MELATONIN DAN MELATONIN RECEPTOR AGONIST SEBAGAI PENANGANAN INSOMNIA PRIMER KRONIS

e-Jurnal Medika Udayana, 2013
Melatonin is a hormone that has an important role in the mechanism of sleep. Hypnotic effects of melatonin and melatonin receptor agonist are mediated via MT1 and MT2 receptors, especially in circadian rhythm pacemaker, suprachiasmatic nucleus, which is ...
Ni Luh Putu Ayu Maha Iswari, Anak Ayu Sri Wahyuni   +1 more
doaj  

Integrating classical and quantum mechanics in melatonin receptors for structure-guided drug design

Academia Biology
Although melatonin receptor agonists are acknowledged for their therapeutic potential for managing sleep problems, the structural optimization of these compounds is made challenging by variations in crystallographic data.
Gabriela de Lima Menezes, Gabriel Vinícius Rolim da Silva, Katyanna Sales Bezerra, Marielena Vogel Saivish, Clara Sales Gurgel Ribeiro Dantas, Douglas Soares Galvão, John Fontenele Araújo, Jonas Ivan Nobre Oliveira, Roosevelt Alves da Silva, Umberto Laino Fulco   +9 more
doaj   +1 more source

Polymorphism of the MTNR1A Melatonin Receptor Gene in Goat Breeds of Northern Italy. [PDF]

Animals (Basel), 2023
Agradi S, Luridiana S, Mura MC, Cosso G, Vigo D, Menchetti L, Brecchia G, Carcangiu V, Curone G.   +8 more
europepmc   +1 more source

Melatonin receptor structure and signaling

Journal of Pineal Research
AbstractMelatonin (5‐methoxy‐N‐acetyltryptamine) binds with high affinity and specificity to membrane receptors. Several receptor subtypes exist in different species, of which the mammalian MT1 and MT2 receptors are the best‐characterized. They are members of the G protein‐coupled receptor superfamily, preferentially coupling to Gi/o proteins but also ...
Okamoto, Hiroyuki, Cecon, Erika, Nureki, Osamu, Rivara, Silvia, Jockers, Ralf   +4 more
openaire   +4 more sources

Blue Light and Temperature Actigraphy Measures Predicting Metabolic Health Are Linked to Melatonin Receptor Polymorphism. [PDF]

Biology (Basel), 2023
Gubin D, Danilenko K, Stefani O, Kolomeichuk S, Markov A, Petrov I, Voronin K, Mezhakova M, Borisenkov M, Shigabaeva A, Yuzhakova N, Lobkina S, Weinert D, Cornelissen G.   +13 more
europepmc   +1 more source

P71 | THE EXTRACELLULAR VESICLE POPULATIONS UNDERWENT ALTERATIONS SUBSEQUENT TO THE PRETREATMENT OF ADIPOSE-DERIVED STEM CELLS WITH MELATONIN RECEPTOR AGONIST

European Journal of Histochemistry
Melatonin, a neurohormone primarily involved in the regulation of circadian rhythms, exerts its physiological effects through MT1 and MT2 receptors expressed in various tissues, including adipose derived stem cells (ADSCs). Beyond its role in sleep-wake
doaj   +1 more source

The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story. [PDF]

Ann Med, 2023
Zhu H, Zhao ZJ, Liu HY, Cai J, Lu QK, Ji LD, Xu J.   +6 more
europepmc   +1 more source