Non-skeletal activities of vitamin d: From physiology to brain pathology [PDF]
, 2019 Vitamin D is a secosteroid hormone regulating the expression of almost 900 genes, and it is involved in the regulation of calcium and phosphate metabolism, immune response, and brain development.
Bruna Lo Sasso +6 more
core +1 more source
Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity
British Journal of Clinical Pharmacology, EarlyView.Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa +5 more
wiley +1 more source
Melatonin Transmits Photoperiodic Signals through the MT1 Melatonin Receptor [PDF]
The Journal of Neuroscience, 2009 Melatonin transmits photoperiodic signals that regulate reproduction. Two melatonin receptors (MT1 and MT2) have been cloned in mammals and additional melatonin binding sites suggested, but the receptor that mediates the effects of melatonin on the photoperiodic gonadal response has not yet been identified. We therefore investigated in mice whether and
Shinobu, Yasuo +3 more
openaire +2 more sources
Expression of three GnRH receptors in specific tissues in male and female sea lampreys Petromyzon marinus at three distinct life stages [PDF]
, 2013 Two recently cloned gonadotropin-releasing hormone (GnRH) receptors (lamprey GnRH-R-2 and lamprey GnRH-R-3) along with lamprey (l) GnRH-R-1 were shown to share similar structural features and amino acid motifs common to other vertebrate receptors.
Daukss, Dana M. +3 more
core +1 more source
The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats. [PDF]
, 2014 The hypocretin receptor (HcrtR) antagonist almorexant (ALM) has potent hypnotic actions but little is known about neurocognitive performance in the presence of ALM.
Kilduff, Thomas S +4 more
core +2 more sources
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source
Timing as a sexually selected trait: the right mate at the right moment [PDF]
, 2017 Sexual selection favours the expression of traits in one sex that attract members of the opposite sex for mating. The nature of sexually selected traits such as vocalization, colour and ornamentation, their fitness benefits as well as their costs have ...
Buck, C. Loren +7 more
core +3 more sources
PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature
Clinical Pharmacology &Therapeutics, EarlyView.The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Katalin Monostory +13 more
wiley +1 more source
Growing Teeth in the Dark: Circadian Rhythmic Tooth Growth Regulated by Melatonin?
Dental Hypotheses, 2011 Introduction: Melatonin is re-leased from the pineal gland and its release is regulated by the light. It is a well-known hormone for circadian rhythm that affects various activities of our body.
Gang Shen +3 more
doaj
Agomelatine is superior to melatonin in pain suppression: An experimental study
Neurological Sciences and Neurophysiology, 2020 Objective: Agomelatine is a synthetic analog of melatonin with selective agonist action on melatonin MT1 and MT2 receptors and antagonistic effect on serotonin 5HT2c receptors. Similar to melatonin, it also has antinociceptive properties.
Ali Okan Yucel +3 more
doaj +1 more source