Results 81 to 90 of about 2,729,675 (338)

Clinical usefulness of melatonin MT1 and MT2 receptor agonists in the treatment of sleep disorders and depression

Medycyna Ogólna i Nauki o Zdrowiu, 2022
Introduction and objective Melatonin is the most important compound produced by the pineal gland. Its daily secretion cycle is responsible for the normal rhythm of sleep and wakefulness.
Sara Hmaidan, Ewa Gibuła-Tarłowska, Paweł Grochecki, Ewa Kędzierska   +3 more
doaj   +1 more source

Research progress on the role of melatonin and its receptors in animal reproduction: A comprehensive review

Reproduction in domestic animals = Zuchthygiene, 2018
Melatonin and its receptors play a crucial role in the regulation of the animal reproductive process, primarily in follicular development. However, the role that melatonin performs in regulating hormones related with reproduction remains unclear ...
Hira sajjad Talpur, IB Chandio, Rahim Dad Brohi, Tesfaye Worku, Zia Ur Rehman, D. Bhattarai, Farman Ullah, L. Jiajia, Liguo Yang   +8 more
semanticscholar   +1 more source

Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism

Frontiers in Endocrinology, 2019
Melatonin, a hormone synthesized by both the pineal gland and retina, functions as an important modulator of a number of physiological functions.
Sharon Owino, Sharon Owino, Daniella D. C. Buonfiglio, Daniella D. C. Buonfiglio, Cynthia Tchio, Gianluca Tosini   +5 more
doaj   +1 more source

Clock genes regulate Ca2+ signaling and mitochondrial bioenergetics to inhibit Sjogren's disease

Arthritis &Rheumatology, Accepted Article.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjogren's disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA seq, and mitochondrial activity were used to investigate the effects of ...
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento Da Conceicao, Neelanjan Vishnu, Shankara N Varadarajan, Venugopal R. Bovilla, Rajender K Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Cross-species comparison of AlphaFold-derived G protein-coupled receptor structures reveals novel melatonin-related receptor in Neurospora crassa.

PLoS ONE
Melatonin, a molecule with diverse biological functions, is ubiquitously present in living organisms. There is significant interest in understanding melatonin signal transduction pathways in humans, particularly due to its critical role in regulating the
Cathryn S D Maienza, Guillaume Lamoureux, Kwangwon Lee   +2 more
doaj   +1 more source

Genetic effects of melatonin receptor genes on chicken reproductive traits

Czech Journal of Animal Science, 2013
The melatonin receptors are G protein-coupled receptors (GPCR) that bind melatonin. Three types of melatonin receptors have been cloned. The MTNR1A (or Mel1A or MT1) and MTNR1B (or Mel1B or MT2) receptor subtypes are present in humans and other mammals ...
D.Y. Li, L. Zhang, D.G. Smith, H.L. Xu, Y.P. Liu, X.L. Zhao, Y. Wang, Q. Zhu   +7 more
doaj   +1 more source

The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination [PDF]

, 2016
Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. The protective effects of melatonin (MLT) on various neurodegenerative diseases, including MS, have been suggested.
Ghadiri, T., Ghaemi, A., Gorji, A., Khodagholi, F., Noorbakhsh, F., Sharifzadeh, M., Vakilzadeh, G.   +6 more
core  

The effect of melatonin on bacterial translocation following ischemia/reperfusion injury in a rat model of superior mesenteric artery occlusion [PDF]

, 2015
Background: Acute mesenteric ischemia is a life-threatening vascular emergency resulting in tissue destruction due to ischemia-reperfusion injury. Melatonin, the primary hormone of the pineal gland, is a powerful scavenger of reactive oxygen species (ROS)
Aydin, B., Aydin, C., Berber, I., Birsen, O., Cevahir, N., Gumrukcu, G., Yenisey, C., Özban, Murat.   +7 more
core   +2 more sources

Adverse Childhood Experiences in Autistic and Neurotypical Girls

Autism Research, EarlyView.
ABSTRACT Adverse childhood experiences (ACEs) are potentially traumatic, life‐altering events that occur in childhood with long‐term negative physical and/or mental health outcomes. Previous research, while limited and largely focused on males, suggests children with autism spectrum disorder (ASD) are at higher risk of experiencing ACEs than typically ...
Jon Ebert, Rachael A. Muscatello, Trey McGonigle, Simon Vandekar, Blythe A. Corbett   +4 more
wiley   +1 more source

A Review of the Role of Melatonin in Irritable Bowel Syndrome [PDF]

, 2014
Irritable bowel syndrome (IBS) is a troubling disease experienced worldwide. The presentation of symptoms varies from patient to patient, and current prescription treatments can be inadequate in resolving symptoms.
Brinn, Nicole R., Gandhi, Mona A.
core   +1 more source