Results 121 to 130 of about 25,767 (309)

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors. [PDF]

J Chem Inf Model, 2022
Elisi GM, Scalvini L, Lodola A, Mor M, Rivara S.   +4 more
europepmc   +1 more source

The capability of L-carnitine-mediated antioxidant on cock during aging: evidence for the improved semen quality and enhanced testicular expressions of GnRH1, GnRHR, and melatonin receptors MT 1/2

, 2019
Abdelmotaleb Elokil, Ali Akbar Bhuiyan, Huazhen Liu, Mona N. Hussein, Hafiz I. Ahmed, Syed Ali Azmal, Liubin Yang, Shijun Li   +7 more
openalex   +1 more source

Melatonin regulates the expression of Bone Morphogenetic Protein 15 (Bmp-15), Growth Differentiation Factor 9 (Gdf-9) and LH receptor (Lhr) genes in developing follicles of rats

, 2020
Lia de Alencar Coelho, Daniella do Carmo Buonfiglio, Wilson Mitsuo Tatagiba Kuwabara, Jéssica Andrade-Silva, Patrícia Rodrigues Lourenço Gomes, Julieta Helena Scialfa, Rafael Peres, Fernanda Gaspar do Amaral, José Cipolla‐Neto   +8 more
openalex   +2 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Shumian Capsule Improves the Sleep Disorder and Mental Symptoms Through Melatonin Receptors in Sleep-Deprived Mice. [PDF]

Front Pharmacol, 2022
Li W, Cheng Y, Zhang Y, Qian Y, Wu M, Huang W, Yang N, Liu Y.   +7 more
europepmc   +1 more source

Hepatoprotective actions of melatonin: Possible mediation by melatonin receptors

World Journal of Gastroenterology, 2010
Melatonin, the hormone of darkness and messenger of the photoperiod, is also well known to exhibit strong direct and indirect antioxidant properties. Melatonin has previously been demonstrated to be a powerful organ protective substance in numerous models of injury; these beneficial effects have been attributed to the hormone's intense radical ...
openaire   +2 more sources

OR22-5 Effect of Melatonin Receptor 1 on Glucose and Lipid Metabolism in Melatonin-proficient (c3hf+ ∕+) Female Mice [PDF]

, 2022
Varunika Goyal
openalex   +1 more source

Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring

Cell Proliferation, EarlyView.
Maternal SD during pregnancy enhances the development of diet‐induced NASH in adult offspring of both sexes through an NR4A3‐dependent mechanism, characterised by heightened inflammation and increased apoptosis. Maternal melatonin supplementation effectively alleviates this increased susceptibility to NASH in offspring.
Fei Guo, Zexin Yang, Junsen She, Chen Fang, Yizhi Hu, Hefeng Huang, Ling Gao   +6 more
wiley   +1 more source

Negative regulation of melatonin secretion by melatonin receptors in ovine pinealocytes. [PDF]

PLoS One, 2021
Lépinay J, Taragnat C, Dubois JP, Chesneau D, Jockers R, Delagrange P, Bozon V.   +6 more
europepmc   +1 more source