Results 31 to 40 of about 25,767 (309)

Influence of melatonin on the development of functional nicotinic acetylcholine receptors in cultured chick retinal cells

Brazilian Journal of Medical and Biological Research, 2005
The influence of melatonin on the developmental pattern of functional nicotinic acetylcholine receptors was investigated in embryonic 8-day-old chick retinal cells in culture. The functional response to acetylcholine was measured in cultured retina cells
L.F.S. Sampaio, D.E. Hamassaki-Britto, R.P. Markus   +2 more
doaj   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Dampening of neurotransmitter action: molecular similarity within the melatonin structure

Endocrine Regulations, 2018
Objectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides.
Williams Wynford R.
doaj   +1 more source

Preliminary Evaluation of Human Gingiva as an Extrapineal Site of Melatonin Biosynthesis in States of Periodontal Health and Disease [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Melatonin is a pineal gland hormone that plays an important role in periodontal homeostasis. Extra pineal melatonin production has been found to occur in tissues like the ovaries, retina and gastrointestinal tract.
Balaji Thodur Madapusi, Suresh Ranga Rao
doaj   +1 more source

Characterization of central melatonin receptors using ¹²⁵I‐melatonin [PDF]

FEBS Letters, 1986
The binding of 125I‐melatonin, a potent analog of melatonin, to rat brain synaptosomal preparations was investigated. 125I‐melatonin bound with high affinity (K d = 38 nM) to a single class of sites (B max = 81 protein). Kinetic studies indicated that binding was time‐dependent and reversible. Specific 125I‐melatonin binding was inhibited by melatonin,
Laudon, Moshe, Zisapel, Nava
openaire   +2 more sources

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Is Melatonin the Cornucopia of the 21st Century?

Antioxidants, 2020
Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) and regulating the sleep/wake cycle in humans.
Nadia Ferlazzo, Giulia Andolina, Attilio Cannata, Maria Giovanna Costanzo, Valentina Rizzo, Monica Currò, Riccardo Ientile, Daniela Caccamo   +7 more
doaj   +1 more source

Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. [PDF]

PLoS ONE, 2016
Melatonin is rhythmically secreted by both the pineal gland and retina in a circadian fashion, with its peak synthesis occurring during the night. Once synthesized, melatonin exerts its effects by binding to two specific G-protein coupled receptors ...
Sharon Owino, Susana Contreras-Alcantara, Kenkichi Baba, Gianluca Tosini   +3 more
doaj   +1 more source

Seasonal Variation of Melatonin Concentration and mRNA Expression of Melatonin-Related Genes in Developing Ovarian Follicles of Mares Kept under Natural Photoperiods in the Southern Hemisphere

Animals, 2023
This study investigated the seasonal variations in mRNA expression of FSH (Fshr), LH (Lhr) receptors, melatonin (Mt1 and Mt2) receptors, melatonin-synthetizing enzymes (Asmt and Aanat) and melatonin concentration in developing follicles from mares raised
Lia Alencar Coelho, Luciano Andrade Silva, Ana Paula Reway, Daniella Do Carmo Buonfiglio, Jéssica Andrade-Silva, Patrícia Rodrigues Lourenço Gomes, José Cipolla-Neto   +6 more
doaj   +1 more source