Results 41 to 50 of about 25,767 (309)

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

Advanced Science, EarlyView.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei, Wei Liu, Bili Cao, Dan Zhao, Chengqiang Wang, Xin Hou, Tangyuan Ning, Biao Gong   +7 more
wiley   +1 more source

Circadian Rhythm Regulates Development of Enamel in Mouse Mandibular First Molar. [PDF]

PLoS ONE, 2016
Rhythmic incremental growth lines and the presence of melatonin receptors were discovered in tooth enamel, suggesting possible role of circadian rhythm.
Jiang Tao, Yue Zhai, Hyun Park, Junli Han, Jianhui Dong, Ming Xie, Ting Gu, Keidren Lewi, Fang Ji, William Jia   +9 more
doaj   +1 more source

Adverse Childhood Experiences in Autistic and Neurotypical Girls

Autism Research, EarlyView.
ABSTRACT Adverse childhood experiences (ACEs) are potentially traumatic, life‐altering events that occur in childhood with long‐term negative physical and/or mental health outcomes. Previous research, while limited and largely focused on males, suggests children with autism spectrum disorder (ASD) are at higher risk of experiencing ACEs than typically ...
Jon Ebert, Rachael A. Muscatello, Trey McGonigle, Simon Vandekar, Blythe A. Corbett   +4 more
wiley   +1 more source

Melatonin Modulates the GABAergic Response in Cultured Rat Hippocampal Neurons

Journal of Pharmacological Sciences, 2012
In the present study, we investigated the effect of melatonin on the GABA-induced current (IGABA) and GABAergic miniature inhibitory postsynaptic currents (mIPSCs) in cultured rat hippocampal neurons using the whole-cell patch-clamp technique.
Xin-Ping Cheng, Hao Sun, Zeng-You Ye, Jiang-Ning Zhou   +3 more
doaj   +1 more source

Melatonin Receptor Genes in Vertebrates [PDF]

International Journal of Molecular Sciences, 2013
Melatonin receptors are members of the G protein-coupled receptor (GPCR) family. Three genes for melatonin receptors have been cloned. The MT1 (or Mel1a or MTNR1A) and MT2 (or Mel1b or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype, Mel1c (or MTNR1C), has been identified in fish ...
Di Li, David Smith, Rüdiger Hardeland, Ming Yang, Huai Xu, Long Zhang, Hua Yin, Qing Zhu   +7 more
openaire   +3 more sources

Prevalence and impact of prescribing cascades in community‐dwelling adults: Longitudinal analysis of the Irish longitudinal study on ageing (TILDA)

British Journal of Clinical Pharmacology, EarlyView.
Prescribing cascades occur when medication is prescribed to prevent/treat the adverse effects of another medication and may be intentional/unintentional. This study examines the prevalence of nine prescribing cascades (ThinkCascades) in The Irish Longitudinal StuDy on Ageing (TILDA).
Ann Sinéad Doherty, Rose Anne Kenny, Frank Moriarty, Fiona Boland, Barbara Clyne, Tom Fahey, Denis O' Mahony, Emma Wallace   +7 more
wiley   +1 more source

Pharmacological modulation of MRAP2 protein on murine melatonin receptor signaling

Frontiers in Endocrinology
IntroductionMTNR1A and MTNR1B, crucial for regulating circadian rhythms and various physiological processes, have well- established biological significance.
Wenqi Song, Yanchuan Li, Hongtao Xu, Yaqun Zhang, Liu Liu, Yihao Li, Xinran Wang, Yueming Du, Yining Chen, Jianjun Lyu, Lingjing Jin, Chao Zhang, Yuchen Xiao   +12 more
doaj   +1 more source

Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer’s disease

European Journal of Histochemistry, 2009
The pineal hormone melatonin is involved in physiological transduction of temporal information from the light dark cycle to circadian and seasonal behavioural rhythms, as well as possessing neuroprotective properties.
P Brunner, N Sözer-Topcular, R Jockers, R Ravid, D Angeloni, F Fraschini   +5 more
doaj   +1 more source

Cardiac-targeted delivery of nuclear receptor RORα via ultrasound targeted microbubble destruction optimizes the benefits of regular dose of melatonin on sepsis-induced cardiomyopathy

Biomaterials Research, 2023
Background Large-dose melatonin treatment in animal experiments was hardly translated into humans, which may explain the dilemma that the protective effects against myocardial injury in animal have been challenged by clinical trials.
Shanjie Wang, Kegong Chen, Ye Wang, Zeng Wang, Zhaoying Li, JunChen Guo, Jianfeng Chen, Wenhua Liu, Xiaohui Guo, Guangcan Yan, Chenchen Liang, Huai Yu, Shaohong Fang, Bo Yu   +13 more
doaj   +1 more source

Clinical usefulness of melatonin MT1 and MT2 receptor agonists in the treatment of sleep disorders and depression

Medycyna Ogólna i Nauki o Zdrowiu, 2022
Introduction and objective Melatonin is the most important compound produced by the pineal gland. Its daily secretion cycle is responsible for the normal rhythm of sleep and wakefulness.
Sara Hmaidan, Ewa Gibuła-Tarłowska, Paweł Grochecki, Ewa Kędzierska   +3 more
doaj   +1 more source