Results 121 to 130 of about 364 (156)
Meldonium residues in milk: A possible scenario for inadvertent doping in sports?
Drug Testing and Analysis, 2021 The veterinary drug Emidonol® has been discussed as a possible scenario for inadvertent doping in sports. In a recent study, meldonium concentrations determined in raw milk reached up to 701 ng/ml. If consumed, urine collected post‐ingestion can present meldonium residues and adverse analytical findings in doping controls cannot be excluded.
Christian Gorgens +2 more
exaly +2 more sources
Meldonium: Pharmacological, toxicological, and analytical aspects [PDF]
Toxicology Research and Application, 2020 Meldonium is the active molecule from Mildronate® with similar chemical structure to an amino acid, and it is known as (3-(2,2,2-trimethylhydrazine) propionate) (CAS 76144-81-5). This pharmaceutical substance is approved in Eastern Europe for cerebral and myocardial ischemia and has been on the World Doping Association’s banned substances list since ...
André Valle De Bairros
exaly +2 more sources
Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses [PDF]
Drug Testing and Analysis, 2017 Although developed as a therapeutic medication, meldonium has found widespread use in human sports and was recently added to the World Anti‐Doping Agency's list of prohibited substances. Its reported abuse potential in human sports has led to concern by regulatory authorities about the possible misuse of meldonium in equine athletics.
Mikael Hedeland, Heather Knych
exaly +3 more sources
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Meldonium in Treatment of Patients With Myocardial Infarction
Kardiologiia, 2014Therapy with meldonium belongs to "metabolic direction" which is developing in cardiovascular medicine. Its purpose is restoration of impaired cellular metabolism.
G I, Nechaeva +2 more
openaire +2 more sources
Pharmacological Research, 2016 Meldonium (mildronate; 3-(2,2,2-trimethylhydrazinium)propionate; THP; MET-88) is a clinically used cardioprotective drug, which mechanism of action is based on the regulation of energy metabolism pathways through l-carnitine lowering effect. l-Carnitine biosynthesis enzyme γ-butyrobetaine hydroxylase and carnitine/organic cation transporter type 2 ...
Reinis Vilskersts +2 more
exaly +3 more sources
Sixty seconds on . . . meldonium
BMJ, 2016Yes, definitely a double fault for the Russian tennis star. Meldonium (also known as mildronate) is a drug made in Latvia used for treating heart failure, angina, and myocardial infarction. It isn’t licensed in the United States or Europe. We don’t know, but it seems unlikely. She has said that she had magnesium …
openaire +1 more source
Testing for Meldonium, a Doping Agent, in Human Hair
Drug Testing and AnalysisABSTRACT Meldonium has been developed in the 70s in Latvia and is currently used in a limited number of countries for heart‐related diseases, such as heart attack, failure, or angina pectoris. Due to its metabolic properties (decrease of lactate production, increase of glycogen use, and protective action again ...
, Pascal Kintz, Laurie Gheddar
exaly +3 more sources
Analytical methods for meldonium determination in urine samples
Analytical Letters, 2020Here is reported a rapid analytical method for meldonium and other beta blockers (metoprolol, amlodipine, bisoprolol, nebivolol, betaxolol, and carvediol) in urine samples using Fourier transform i...
L. D. Rusu +4 more
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Efficiency of Meldonium in the Complex Therapy of Acute Coronary Syndrome
Kardiologiia, 2014We examined 140 patients (mean age 54.8±3.1 years) with ST elevation acute coronary syndrome resulting in Q-wave myocardial infarction of the left ventricle. From the first hours complex therapy of these patients comprised meldonium (1 g/day intravenously for 2 weeks then orally until 1.5 months).
V P, Mikhin +4 more
openaire +2 more sources
The Ability to use Meldonium as Adaptogen in Winter in Patients With Cardiovascular Disease
Kardiologiia, 2014Given that the effects of frost can play the role of independent stress factor influencing the course of cardiovascular disease (CVD), it is reasonable to supplementation of drugs that increase the body's resistance to cold stress. Aim: To evaluate the possibility of using meldonium to prevent unwanted seasonal changes in CVD patients in the winter ...
M D, Smirnova +5 more
openaire +2 more sources