Results 1 to 10 of about 206 (146)

Screening of cytoprotectors against methotrexate-induced cytogenotoxicity from bioactive phytochemicals [PDF]

PeerJ, 2016
As a well known anti-neoplastic drug, the cytogenotoxicity of methotrexate (MTX) has received more attention in recent years. To develop a new cytoprotector to reduce the risk of second cancers caused by methotrexate, an umu test combined with a ...
Shaobin Gu, Ying Wu, Jianbo Yang
doaj   +5 more sources

Coal-Derived Humic Substances: Insight into Chemical Structure Parameters and Biomedical Properties [PDF]

Molecules
An investigation was carried out on humic substances (HSs) isolated from the coal of the Kansk-Achinsk basin (Krasnoyarsk Territory, Russia). The coal HSs demonstrate the main parameters of molecular structure inherent to this class of natural compounds.
Maria V Zykova, Mikhail Belousov, Evgeniya Trofimova   +2 more
exaly   +4 more sources

Cytoprotective Activity of Newly Synthesized 3-(Arylmethylamino)-6-Methyl-4-Phenylpyridin-2(1H)-Ones Derivatives [PDF]

Molecules, 2022
Currently, studies are being conducted on the possible role of the cytoprotective effect of biologically active substances in conditions of cerebral hypoxia or cardiomyopathies.
Shynggys Sergazy, Zarina Shulgau, Aigerim Zhulikeyeva, Yerlan Ramankulov, Irina V. Palamarchuk, Ivan V. Kulakov   +5 more
doaj   +2 more sources

Heme-Oxygenase 1 Mediated Activation of Cyp3A11 Protects Against Non-Steroidal Pain Analgesics Induced Acute Liver Damage in Sickle Cell Disease Mice [PDF]

Cells
Pain constitutes a significant comorbidity associated with sickle cell disease (SCD). Analgesics serve as the primary method for pain management; however, the long-term effects of these drugs on the liver of SCD patients remain not completely understood.
Ravi Vats, Ramakrishna Ungalara, Rikesh K. Dubey, Prithu Sundd, Tirthadipa Pradhan-Sundd   +4 more
doaj   +2 more sources

In vitro study of the anticancer activity of various doxorubicin-containing dispersions [PDF]

BioImpacts, 2019
Introduction: The aim of this research was to study the impact of various doxorubicin (Dox)-containing nanofluids, e.g. singlewalled carbon nanotube (SWCNT)+Dox, graphene oxide (GO)+Dox and DextranPNIPAM (copolymer)+Dox mixtures on HeLa cells (human ...
Tatiana Matvienko, Viktoriya Sokolova, Svitlana Prylutska, Yuliia Harahuts, Nataliya Kutsevol, Viktor Kostjukov, Maxim Evstigneev, Yuriy Prylutskyy, Matthias Epple, Uwe Ritter   +9 more
doaj   +2 more sources

Efficacy of a cytoprotector mexicor in urgent cardiology

Терапевтический архив, 2004
Aim. To study efficacy of cytoprotector mexicor in patients with unstable angina (UA), acute myocardial infarction (MI), hypertensive crises (HC) in combined therapy with conventional drugs. Material and methods.
A P Golikov, V P Mikhin, V Yu Polumiskov, S A Boitsov, E N Bogoslovskaya, N V Veselyeva, M M Lukyanov, D V Rudnev, A A Frolov   +8 more
doaj   +1 more source

Regulatory Role and Cytoprotective Effects of Exogenous Recombinant SELENOM under Ischemia-like Conditions and Glutamate Excitotoxicity in Cortical Cells In Vitro [PDF]

Biomedicines
Despite the successes in the prevention and treatment of strokes, it is still necessary to search for effective cytoprotectors that can suppress the damaging factors of cerebral ischemia.
Egor A. Turovsky, Egor Y. Plotnikov, Elena G. Varlamova   +2 more
doaj   +2 more sources

Dehydroepiandrosterone and Its Metabolite 5-Androstenediol: New Therapeutic Targets and Possibilities for Clinical Application [PDF]

Pharmaceuticals
Dehydroepiandrosterone and its sulfate are the most abundant steroids in humans. The metabolism of dehydroepiandrosterone can differ significantly depending on the organ or tissue and the subtype of steroid receptors expressed in it.
Tatiana A. Fedotcheva, Maria E. Uspenskaya, Darya N. Ulchenko, Nikolay L. Shimanovsky   +3 more
doaj   +2 more sources

CYTOPROTECTOR ROLE IN THE MANAGEMENT OF ARTERIAL HYPERTENSION TREATED WITH ENALAPRIL

Российский кардиологический журнал, 2009
The study investigated the effects of cardiac cytoprotectors – mildronate and trimetazidine, combined with ACE therapy, on lipid peroxidation product levels, endothelial function, circadian blood pressure (BP) profile, left ventricular myocardium, and ...
F. E. Khebodarov, V. P. Mikhin
doaj   +1 more source

Myocardial cytoprotectors demonstrate anti-apoptotic effect on vascular endotheliocytes

Кардиоваскулярная терапия и профилактика, 1970
Aim. To evaluate the effects of myocardial cytoprotectors on the levels of apoptotic endotheliocytes and membranederived microparticles of endothelial origin in peripheral blood of the patients with cardiovascular disease (CVD). Material and methods. The
A. I. Inzhutova
doaj   +1 more source