Screening of cytoprotectors against methotrexate-induced cytogenotoxicity from bioactive phytochemicals [PDF]
PeerJ, 2016 As a well known anti-neoplastic drug, the cytogenotoxicity of methotrexate (MTX) has received more attention in recent years. To develop a new cytoprotector to reduce the risk of second cancers caused by methotrexate, an umu test combined with a ...
Shaobin Gu, Ying Wu, Jianbo Yang
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Cytoprotective Activity of Newly Synthesized 3-(Arylmethylamino)-6-Methyl-4-Phenylpyridin-2(1H)-Ones Derivatives [PDF]
Molecules, 2022 Currently, studies are being conducted on the possible role of the cytoprotective effect of biologically active substances in conditions of cerebral hypoxia or cardiomyopathies.
Shynggys Sergazy +5 more
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Heme-Oxygenase 1 Mediated Activation of Cyp3A11 Protects Against Non-Steroidal Pain Analgesics Induced Acute Liver Damage in Sickle Cell Disease Mice [PDF]
CellsPain constitutes a significant comorbidity associated with sickle cell disease (SCD). Analgesics serve as the primary method for pain management; however, the long-term effects of these drugs on the liver of SCD patients remain not completely understood.
Ravi Vats +4 more
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In vitro study of the anticancer activity of various doxorubicin-containing dispersions [PDF]
BioImpacts, 2019 Introduction: The aim of this research was to study the impact of various doxorubicin (Dox)-containing nanofluids, e.g. singlewalled carbon nanotube (SWCNT)+Dox, graphene oxide (GO)+Dox and DextranPNIPAM (copolymer)+Dox mixtures on HeLa cells (human ...
Tatiana Matvienko +9 more
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Coal-Derived Humic Substances: Insight into Chemical Structure Parameters and Biomedical Properties [PDF]
MoleculesAn investigation was carried out on humic substances (HSs) isolated from the coal of the Kansk-Achinsk basin (Krasnoyarsk Territory, Russia). The coal HSs demonstrate the main parameters of molecular structure inherent to this class of natural compounds.
Maria V. Zykova +16 more
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Regulatory Role and Cytoprotective Effects of Exogenous Recombinant SELENOM under Ischemia-like Conditions and Glutamate Excitotoxicity in Cortical Cells In Vitro [PDF]
BiomedicinesDespite the successes in the prevention and treatment of strokes, it is still necessary to search for effective cytoprotectors that can suppress the damaging factors of cerebral ischemia.
Egor A. Turovsky +2 more
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Efficacy of a cytoprotector mexicor in urgent cardiology
Терапевтический архив, 2004 Aim. To study efficacy of cytoprotector mexicor in patients with unstable angina (UA), acute myocardial infarction (MI), hypertensive crises (HC) in combined therapy with conventional drugs. Material and methods.
A P Golikov +8 more
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Dehydroepiandrosterone and Its Metabolite 5-Androstenediol: New Therapeutic Targets and Possibilities for Clinical Application [PDF]
PharmaceuticalsDehydroepiandrosterone and its sulfate are the most abundant steroids in humans. The metabolism of dehydroepiandrosterone can differ significantly depending on the organ or tissue and the subtype of steroid receptors expressed in it.
Tatiana A. Fedotcheva +3 more
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CYTOPROTECTOR ROLE IN THE MANAGEMENT OF ARTERIAL HYPERTENSION TREATED WITH ENALAPRIL
Российский кардиологический журнал, 2009 The study investigated the effects of cardiac cytoprotectors – mildronate and trimetazidine, combined with ACE therapy, on lipid peroxidation product levels, endothelial function, circadian blood pressure (BP) profile, left ventricular myocardium, and ...
F. E. Khebodarov, V. P. Mikhin
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Рациональная фармакотерапия в кардиологии, 2015 Indications for myocardial cytoprotector, trimetazidine, in patients with ischemic heart disease are analyzed and justified according to evidence based medicine.
Zh. M. Sizova
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