Results 11 to 20 of about 205 (151)
Myocardial cytoprotectors demonstrate anti-apoptotic effect on vascular endotheliocytes
Кардиоваскулярная терапия и профилактика, 1970 Aim. To evaluate the effects of myocardial cytoprotectors on the levels of apoptotic endotheliocytes and membranederived microparticles of endothelial origin in peripheral blood of the patients with cardiovascular disease (CVD). Material and methods. The
A. I. Inzhutova
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Comparative effectiveness of myocardial cytoprotectors in chronic heart failure treatment
Российский кардиологический журнал, 2007 The study is focused on comparative effectiveness of myocardial cytoprotectors in chronic heart failure (CHF) treatment. In total, 120 patients with Functional Class (FC) II-III CHF were divided into two groups.
G. G. Semenkova, L. V. Kokoreva
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Changes in Metabolic Regulation and the Microbiota Composition after Supplementation with Different Fatty Acids in db/db Mice. [PDF]
Int J Food Sci, 2022 Introduction. The effects of fatty acids on health vary and depend on the type, amount, and route of consumption. EPA and DHA have a defined role in health, unlike coconut oil. Objective. The aim was to investigate the changes in metabolic regulation and the composition of the culture‐dependent microbiota after supplementation with different fatty ...
Martínez-Carrillo BE +6 more
europepmc +2 more sources
COMPARING MOLECULAR EFFECTS OF VARIOUS CYTOPROTECTORS IN COMPLEX THERAPY OF CORONARY HEART DISEASE
Российский кардиологический журнал, 2009 The molecular effects of trimetazidine and mildronate were investigated in patients with stable effort angina, Functional Class (FC) I-III. The comparison criteria included blood activity and concentrations of the main products of free-radical oxidation ...
E. A. Kartashova
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New data on well-known drug: focus on meldonium
Медицинский совет, 2021 The article reviews the efficacy of meldonium in patients with various diseases, which are based on secondary mitochondrial dysfunction. Mitochondria are complex cellular organelles that control many metabolic processes, including fatty acid oxidation ...
M. E. Statsenko +2 more
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Melatonin Ameliorates Cyclophosphamide‐Induced Spermatogenesis Disorder by Reducing Pyroptosis
Andrologia, Volume 2023, Issue 1, 2023., 2023 As a chemotherapeutic drug, cyclophosphamide (CP) has a negative impact on male fertility due to its reproductive toxicity. Melatonin (Mel) promotes the male reproductive system and increases testosterone synthesis. This study is aimed at exploring the molecular mechanism of Mel as a protector of male fertility against CP‐induced cytotoxicity.
Zhan Song +6 more
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Food Bioengineering, Volume 1, Issue 3-4, Page 298-306, December 2022., 2022 Whey protein was enzymatically hydrolyzed using an ultrahigh‐pressure synergistic enzymolysis method. The identified amino acid sequences were then synthesized, and their antioxidants and DPP‐IV inhibitory activities were determined. Whey protease hydrolysates could potentially be expected to be successfully commercially developed as functional ...
Zheng Yuanrong, Pang Jiakun, Liu Zhenmin
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Autophagy in the retinal pigment epithelium: a new vision and future challenges
The FEBS Journal, Volume 289, Issue 22, Page 7199-7212, November 2022., 2022 RPE cells have different systems (mitophagy, ER‐phagy, xenophagy, lipophagy, ribophagy, pexophagy, aggrephagy, and LAP) for breaking down and recycling damaged materials, allowing them to reduce ‘waste’ and reuse the ‘raw material’. Autophagosomes and phagosomes work as recycler and they take care of the cellular waste transport to the ‘incinerator ...
Daniela Intartaglia +2 more
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Gasdermins mediate cellular release of mitochondrial DNA during pyroptosis and apoptosis
The FASEB Journal, Volume 35, Issue 8, August 2021., 2021 Abstract Pyroptosis and intrinsic apoptosis are two forms of regulated cell death driven by active caspases where plasma membrane permeabilization is induced by gasdermin pores. Caspase‐1 induces gasdermin D pore formation during pyroptosis, whereas caspase‐3 promotes gasdermin E pore formation during apoptosis.
Carlos de Torre‐Minguela +3 more
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Molecular mechanisms of neuroprotective effects of thyroid hormones and their metabolites in acute brain ischemia [PDF]
Анналы клинической и экспериментальной неврологии, 2023 As endovascular reperfusion advances and multimodal neuroimagimg is implemented, neuroprotection in ischemic stroke progresses to the next level. In the recent years, the focus of neuroprotection research has been gradually shifting towards the research ...
Dmitry A. Filimonov +2 more
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