Results 1 to 10 of about 301 (116)
Changes in the Metabolome of Different Tissues in Response to Streptozotocin Diabetes and Mildronate Exposure: A Metabolomic Assessment [PDF]
MetabolitesBackground: Uncontrolled diabetes is characterised by a loss of blood glucose control and increased oxidation of fatty acids to produce ATP. Use of metabolic inhibitors to blunt fatty acid oxidation and restore glucose metabolism is a poorly studied ...
David Hauton +4 more
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Carnitine deficiency alters fuel metabolism and voluntary wheel running in mice [PDF]
Journal of Lipid ResearchCarnitine plays an obligatory role in energetics owing to its role in the translocation of long-chain fatty acids into the mitochondrion for oxidation.
Meagan S. Kingren +7 more
doaj +2 more sources
Gastrointestinal Disorders, 2023 L-carnitine plays a critical role in sperm functioning and maintaining male fertility. Mildronate is a widely used drug for treating cardiovascular diseases.
Artem P. Gureev +5 more
doaj +1 more source
Рациональная фармакотерапия в кардиологии, 2015 Aim. To estimate an effect of metabolic corrector mildronate on cardiac hemodynamics and endothelium function in patients with ischemic heart disease (IHD) and heart failure (HF)Material and methods.
I. V. Sergienko +4 more
doaj +3 more sources
A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesis. [PDF]
PLoS ONE, 2018 L-carnitine is important for the catabolism of long-chain fatty acids in the mitochondria. We investigated how the triacylglycerol (TAG)-lowering drug 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA) influenced lipid metabolism in carnitine-depleted ...
Carine Lindquist +5 more
doaj +1 more source
Кардиоваскулярная терапия и профилактика, 2013 The paper focuses on cytoprotective and additional effects of mildronate. The emphasis is on the latest original research evidence on mildronate effects in the settings of cardiovascular and cerebral ischemia.
I. G. Gordeev, E. O. Taratukhin
doaj +1 more source
Inhibited Carnitine Synthesis Causes Systemic Alteration of Nutrient Metabolism in Zebrafish
Frontiers in Physiology, 2018 Impaired mitochondrial fatty acid β-oxidation has been correlated with many metabolic syndromes, and the metabolic characteristics of the mammalian models of mitochondrial dysfunction have also been intensively studied.
Jia-Min Li +10 more
doaj +1 more source
Рациональная фармакотерапия в кардиологии, 2015 Aim. To study the effect of treatment with metabolic corrector mildronate on lipid profile, inflammatory factors and endothelium function in patients with ischemic heart disease (IHD).Material and methods.
I. V. Sergienko +6 more
doaj +3 more sources
Metabolic (cytoprotective) therapy of menopausal disturbances
Кардиоваскулярная терапия и профилактика, 2011 The paper presents modern views on cardiovascular aspects of menopause and metabolic therapy of menopausal disturbances with meldonium (Mildronate®). The role of estrogen deficiency in climacteric disturbance development, key pathogenetic mechanisms of ...
S. N. Tolstov, V. B. Mychka
doaj +1 more source
Рациональная фармакотерапия в кардиологии, 2016 Aim. To study effect of mildronate on stream-dependent vasodilation in patients with chronic heart failure (CHF).Material and methods. 30 patients with CHF taking standard therapy (diuretic, ACE inhibitor, β- blocker) as well as 30 healthy volunteers ...
L. G. Voronkov +2 more
doaj +1 more source