Results 1 to 10 of about 354 (165)

Changes in the Metabolome of Different Tissues in Response to Streptozotocin Diabetes and Mildronate Exposure: A Metabolomic Assessment [PDF]

Metabolites
Background: Uncontrolled diabetes is characterised by a loss of blood glucose control and increased oxidation of fatty acids to produce ATP. Use of metabolic inhibitors to blunt fatty acid oxidation and restore glucose metabolism is a poorly studied ...
David Hauton, Dragana Savic, John Walsby-Tickle, Damian Tyler, James S. O. McCullagh   +4 more
doaj   +2 more sources

Mildronate: An Antiischemic Drug for Neurological Indications [PDF]

CNS Neuroscience & Therapeutics, 2005
ABSTRACTMildronate (3‐(2,2,2‐trimethylhydrazinium)propionate; MET‐88; meldonium, quaterine) is an antiischemic drug developed at the Latvian Institute of Organic Synthesis. Mildronate was designed to inhibit carnitine biosynthesis in order to prevent accumulation of cytotoxic intermediate products of fatty acid β‐oxidation in ischemic tissues and to ...
Aleksandrs Gutcaits, Nikolajs Sjakste
exaly   +3 more sources

Inhibited Carnitine Synthesis Causes Systemic Alteration of Nutrient Metabolism in Zebrafish [PDF]

Frontiers in Physiology, 2018
Impaired mitochondrial fatty acid β-oxidation has been correlated with many metabolic syndromes, and the metabolic characteristics of the mammalian models of mitochondrial dysfunction have also been intensively studied.
Jia-Min Li, Ling-Yu Li, Xuan Qin, Pascal Degrace, Laurent Demizieux, Samwel M. Limbu, Samwel M. Limbu, Xin Wang, Mei-Ling Zhang, Dong-Liang Li, Zhen-Yu Du   +10 more
doaj   +2 more sources

A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesis. [PDF]

PLoS ONE, 2018
L-carnitine is important for the catabolism of long-chain fatty acids in the mitochondria. We investigated how the triacylglycerol (TAG)-lowering drug 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA) influenced lipid metabolism in carnitine-depleted ...
Carine Lindquist, Bodil Bjørndal, Christine Renate Rossmann, Asbjørn Svardal, Seth Hallström, Rolf Kristian Berge   +5 more
doaj   +2 more sources

Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism

Journal of Enzyme Inhibition and Medicinal Chemistry, 2009
Carnitine acetyltransferase (CrAT; EC 2.3.1.7) catalyzes the reversible transfer of acetyl groups between acetyl-coenzyme A (acetyl-CoA) and L-carnitine; it also regulates the cellular pool of CoA and the availability of activated acetyl groups. In this study, biochemical measurements, saturation transfer difference (STD) nuclear magnetic resonance ...
Jänis Kuka, Maija Dambrova, Edgars Liepinš   +2 more
exaly   +3 more sources

Mildronate effects on cognitive function in elderly patients with arterial hypertension

Кардиоваскулярная терапия и профилактика, 2012
Aim. To assess the effects of the “interval” (3 months of treatment, followed by treatment-free 3 months) and “persistent” (52 weeks) therapy with Mildronate (500 mg/d) in elderly patients with arterial hypertension (AH) and cognitive dysfunction ...
S. V. Nedogoda, M. E. Statsenko, S. V. Turkina, I. A. Tyshchenko, L. V. Poletaeva, V. V. Tsoma, A. A. Ledyaeva, E. N. Chumachok, O. L. Bykova   +8 more
doaj   +3 more sources

Protection of Testis against Lipopolysaccharide-Induced Toxicity: Mildronate-Induced L-Carnitine Depletion as a Modulator of Gut Microbiome Composition and Gastrointestinal Inflammation

Gastrointestinal Disorders, 2023
L-carnitine plays a critical role in sperm functioning and maintaining male fertility. Mildronate is a widely used drug for treating cardiovascular diseases.
Artem P. Gureev, Polina I. Babenkova, Veronika V. Nesterova, Arina D. Tsvetkova, Mariya V. Gryaznova, Ekaterina A. Shaforostova   +5 more
doaj   +1 more source

THE POSSIBILITY OF USAGE OF METABOLIC CORRECTION THERAPY IN PATIENTS WITH ISCHEMIC HEART DISEASE AND HEART FAILURE

Рациональная фармакотерапия в кардиологии, 2015
Aim. To estimate an effect of metabolic corrector mildronate on cardiac hemodynamics and endothelium function in patients with ischemic heart disease (IHD) and heart failure (HF)Material and methods.
I. V. Sergienko, M. E. Bugriy, T. V. Balahonova, G. A. Tkachev, V. B. Sergienko   +4 more
doaj   +3 more sources

ANTIOXIDANT EFFECT OF MILDRONATE IN PATIENTS AFTER CORONARY REVASCULARISATION

Российский кардиологический журнал, 2009
The study included 149 patients, aged 41–75 years, with Functional Class II-III stable angina, who underwent coronary artery bypass graft (CABG) surgery or percutaneous coronary intervention (PCI).
I. G. Gordeev, E. E. Luchinkina, V. A. Lusov   +2 more
doaj   +1 more source

Mildronate. Chronic fatigue syndrome

Medical alphabet, 2020
Chronic fatigue syndrome (CFS) is a state of constant, impairing quality of life, fatigue, lasting more than 6 months, inexplicable by any of coexisting patient’s pathological conditions. The prevalence of CFS in the world is approximately 2 % of the population (120–140 mln inhabitants of Earth). The etiology of CFS is unknown.
A. V. Filippova, A. P. Pereverzev, E. Yu. Ebzeeva, O. D. Ostroumova   +3 more
openaire   +2 more sources