Changes in the Metabolome of Different Tissues in Response to Streptozotocin Diabetes and Mildronate Exposure: A Metabolomic Assessment [PDF]
MetabolitesBackground: Uncontrolled diabetes is characterised by a loss of blood glucose control and increased oxidation of fatty acids to produce ATP. Use of metabolic inhibitors to blunt fatty acid oxidation and restore glucose metabolism is a poorly studied ...
David Hauton +4 more
doaj +2 more sources
Mildronate: An Antiischemic Drug for Neurological Indications [PDF]
CNS Neuroscience & Therapeutics, 2005 ABSTRACTMildronate (3‐(2,2,2‐trimethylhydrazinium)propionate; MET‐88; meldonium, quaterine) is an antiischemic drug developed at the Latvian Institute of Organic Synthesis. Mildronate was designed to inhibit carnitine biosynthesis in order to prevent accumulation of cytotoxic intermediate products of fatty acid β‐oxidation in ischemic tissues and to ...
Nikolajs Sjakste, Aleksandrs Gutcaits
exaly +3 more sources
Inhibited Carnitine Synthesis Causes Systemic Alteration of Nutrient Metabolism in Zebrafish [PDF]
Frontiers in Physiology, 2018 Impaired mitochondrial fatty acid β-oxidation has been correlated with many metabolic syndromes, and the metabolic characteristics of the mammalian models of mitochondrial dysfunction have also been intensively studied.
Jia-Min Li +10 more
doaj +2 more sources
A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesis. [PDF]
PLoS ONE, 2018 L-carnitine is important for the catabolism of long-chain fatty acids in the mitochondria. We investigated how the triacylglycerol (TAG)-lowering drug 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA) influenced lipid metabolism in carnitine-depleted ...
Carine Lindquist +5 more
doaj +2 more sources
Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism
Journal of Enzyme Inhibition and Medicinal Chemistry, 2009 Carnitine acetyltransferase (CrAT; EC 2.3.1.7) catalyzes the reversible transfer of acetyl groups between acetyl-coenzyme A (acetyl-CoA) and L-carnitine; it also regulates the cellular pool of CoA and the availability of activated acetyl groups. In this study, biochemical measurements, saturation transfer difference (STD) nuclear magnetic resonance ...
Kristaps Jaudzems +2 more
exaly +3 more sources
Mildronate effects on cognitive function in elderly patients with arterial hypertension
Кардиоваскулярная терапия и профилактика, 2012 Aim. To assess the effects of the “interval” (3 months of treatment, followed by treatment-free 3 months) and “persistent” (52 weeks) therapy with Mildronate (500 mg/d) in elderly patients with arterial hypertension (AH) and cognitive dysfunction ...
S. V. Nedogoda +8 more
doaj +3 more sources
Кардиоваскулярная терапия и профилактика, 2014 Aim. To assess the effectiveness of Mildronate in the prevention of arrhythmias during the perioperative period of open cholecystectomy under intravenous multicomponent anesthesia.Material and methods.
V. P. Mikhin +3 more
doaj +2 more sources
Gastrointestinal Disorders, 2023 L-carnitine plays a critical role in sperm functioning and maintaining male fertility. Mildronate is a widely used drug for treating cardiovascular diseases.
Artem P. Gureev +5 more
doaj +1 more source
TRIMETAZIDINE AND MILDRONATE AS DIRECT ACTION Β2 - ADRENOSENSIBILIZERS (EXPERIMENTAL EVIDENCE)
Российский кардиологический журнал, 2002 Trimetazidine and mildronate as direct action β2 - adrenosensibilizers (experimental evidence).
V. I. Tsirkin +6 more
doaj +1 more source
ANTIOXIDANT EFFECT OF MILDRONATE IN PATIENTS AFTER CORONARY REVASCULARISATION
Российский кардиологический журнал, 2009 The study included 149 patients, aged 41–75 years, with Functional Class II-III stable angina, who underwent coronary artery bypass graft (CABG) surgery or percutaneous coronary intervention (PCI).
I. G. Gordeev +2 more
doaj +1 more source