Results 31 to 40 of about 961 (200)
Mildronate in cardiology practice – current evidence, ongoing research, and future perspectives
Кардиоваскулярная терапия и профилактика, 2012 The review discusses the benefits and various practical aspects of the new cardioprotector mildronate use in cardiology. The latest evidence on the mildronate role in complex therapy of patients with stable angina, or patients in the rehabilitation ...
V. P. Mikhin +3 more
doaj +1 more source
Structural Properties, Order-Disorder Phenomena and Phase Stability of Orotic Acid Crystal Forms [PDF]
, 2016 Orotic acid (OTA) is reported to exist in the anhydrous (AH), monohydrate (Hy1) and dimethylsulfoxide monosolvate (SDMSO) forms. In this study we investigate the (de)hydration/desolvation behavior, aiming at an understanding of the elusive structural ...
Brittain H. G. +12 more
core +3 more sources
Journal of Diabetes Research, Volume 2018, Issue 1, 2018., 2018 The prevalence of diabetes is steadily rising, and once it occurs, it can cause multiple complications with a negative impact on the whole organism. Complications of diabetes may be macrovascular: such as stroke and ischemic heart disease as well as peripheral vascular and microvascular diseases—retinopathy, nephropathy, and neuropathy.
Alina Mihaela Leustean +7 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 3, Issue 4, Page 266-274, 2010., 2010 In addition to hemorrhagic cystitis, Fanconi Syndrome is a serious clinical side effect during ifosfamide (IFO) therapy. Fanconi syndrome is a generalized dysfunction of the proximal tubule which is characterized by excessive urinary excretion of glucose, phosphate, bicarbonate, amino acids and other solutes excreted by this segment of the nephron ...
Mohamed M. Sayed-Ahmed +2 more
wiley +1 more source
Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat [PDF]
, 2018 The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with ...
Al Kury, L. +7 more
core +3 more sources
Meldonium (Mildronate): Primum nоn nocere
Pharmacological Research, 2016 [No abstract available]
openaire +4 more sources
Partial deficiency of HIF-1α stimulates pathological cardiac changes in streptozotocin-induced diabetic mice [PDF]
, 2014 BACKGROUND: Diabetic cardiomyopathy is associated with a number of functional and structural pathological changes such as left ventricular dysfunction, cardiac remodeling, and apoptosis.
David Sedmera +6 more
core +1 more source
Investigating New Drug Options for Temozolomide Resistant IDH1 Mutant Glioma [PDF]
, 2023 Gliomas, a prevalent form of malignant brain tumors in adults, often exhibit mutations in the isocitrate dehydrogenase 1 (IDH1) gene. Temozolomide (TMZ) is a commonly used chemotherapy drug for treating gliomas; however, the development of drug ...
Sun, Xueyuan
core +1 more source
Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction [PDF]
, 2006 The inhibition of gamma-butyrobetaine (GBB) hydroxylase, a key enzyme in the biosynthesis of carnitine, contributes to lay ground for the cardioprotective mechanism of action of mildronate.
Dambrova, Maija +6 more
core +1 more source
MELDONIUM: EFFECTIVE ACTION POINTS
Кардиоваскулярная терапия и профилактика, 2013 The paper is focused on hypoxia and cell ischemia as universal pathogenetic mechanisms of disease development, which can be addressed by both etiotropic and pathogenetic therapy. The latter is represented by the so-called metabolic correctors. At present,
A. L. Vertkin +4 more
doaj +1 more source