Results 41 to 50 of about 961 (200)

Elevated vascular γ-butyrobetaine levels attenuate the development of high glucose-induced endothelial dysfunction [PDF]

, 2013
The aim of the present study was to investigate the effects of vascular tissue levels of l-carnitine and its precursor, γ-butyrobetaine (GBB), on the development of endothelial dysfunction induced by 5 μmol/L lysophosphatidylcholine (LPC), 10 mmol/L ...
Agouni, Akahira, Bartus, Bueno, Cosentino, Dambrova, Dambrova, Dambrova, Fang, Froese, Guo, Irat, Kawano, Kuka, Liepinsh, Liepinsh, Liepinsh, Meng, Nathanson, O'Brien, Rebouche, Simkhovich, Strijbis, Vilskersts, Vilskersts, Vlies, Witztum, Zanetti   +27 more
core   +1 more source

Fatty acid oxidation is critical for the tumorigenic potential and chemoresistance of pancreatic cancer stem cells. [PDF]

J Transl Med
Background: We have previously demonstrated the significant reliance of pancreatic Cancer Stem Cells (PaCSCs) on mitochondrial oxidative phosphorylation (OXPHOS), which enables versatile substrate utilization, including fatty acids (FAs).
Mascaraque M, Courtois S, Royo-García A, Barneda D, Stoian AM, Villaoslada I, Espiau-Romera P, Bokil A, Cano-Galiano A, Jagust P, Heeschen C, Sancho P.   +11 more
europepmc   +3 more sources

NEW PATHOGENETIC FACTORS OF ATHEROSCLEROSIS DEVELOPMENT AND POTENTIAL THERAPEUTIC APPROACHES

Кардиоваскулярная терапия и профилактика, 2013
It has been demonstrated that one of the factors in the pathogenesis of atherosclerosis, with the subsequent development of myocardial infarction (MI), stroke (S), or sudden death (SD), is trimethylaminoxide (TMAO), the end-product of dietary choline ...
I. Ya. Kalvinsh
doaj   +1 more source

The Regulation of Energy Metabolism Pathways Through L-Carnitine Homeostasis [PDF]

, 2011
Non
Edgars Liepinsh, Ivars Kalvinsh, Maija Dambrova   +2 more
core   +1 more source

Histidine Decapeptide‐Incorporating Lipid Nanoparticles with Low Ionizable Lipids Proportion for Efficient Small Interfering RNA Delivery

Macromolecular Bioscience, Volume 25, Issue 9, September 2025.
Following optimization of ionizable lipid proportion via cost‐efficient vortex‐mixing method, lipid nanoparticles (LNPs) with a lower ionizable lipid proportion (27.72%), termed LNP5, are fabricated with histidine decapeptide (His10) during formulation via microfluidic mixing method. His10‐incorporated LNP5 (LNP5H) exhibited a 1.6‐fold increase in gene
Yeonho Bae, Hyeondo Lee, Jun Hyuk Lee, Sangho Yeo, Hyejung Mok   +4 more
wiley   +1 more source

Pharmacological correction of L-NAME-induced oxide deficiency with derivatives of 3-(2,2,2-trimethylhydrazinium) propionate [PDF]

, 2016
This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate ...
Bystrova, N. A., Danilenko, L. M., Dolzhikov, A. A., Kesarev, O. G., Skachilova, S. Y.   +4 more
core   +2 more sources

Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat

ChemMedChem, Volume 19, Issue 24, December 16, 2024.
Inhibitors of the 2‐oxoglutarate (2OG)‐dependent hypoxia‐inducible factor prolyl hydroxylases (PHDs) are used for anemia treatment. Structures of the clinical PHD inhibitors Desidustat and Enarodustat complexed with the 2OG oxygenase factor inhibiting hypoxia‐inducible factor‐α (FIH) provide a basis to guide future PHD/2OG oxygenase inhibitor ...
Thomas P. Corner, Eidarus Salah, Anthony Tumber, Samanpreet Kaur, Yu Nakashima, Mark D. Allen, Lara I. Schnaubelt, Giorgia Fiorini, Lennart Brewitz, Christopher J. Schofield   +9 more
wiley   +1 more source

Мелдониум и нейропротекция. Теория, эксперимент и клиническая практика [PDF]

, 2018
У цьому огляді розглянуті можливості корекції метаболізму при гострій ішемії мозку (ГІМ) шляхом активації стрес-лімітуючих систем при застосуванні вірогідного полімодального метаболічного коректора мелдоніуму.
Муслин, В.П., Погорелов, А.В.   +1 more
core  

Mildronate effectiveness in post-hospital rehabilitation of patients with myocardial infarction

Кардиоваскулярная терапия и профилактика, 2012
Aim. To study the effects of mildronate, as a component of complex therapy, on left ventricular (LV) systolic and diastolic function and exercise capacity (EC) in myocardial infarction (MI) patients undergoing post-hospital rehabilitation.
V. P. Mikhin, O. N. Koltsova
doaj   +1 more source

biobibliogrāfija II [PDF]

, 2015
Latvijas Zinātņu akadēmijas akadēmiķe profesore Vija Zaiga Kluša : biobibliogrāfija II / Latvijas Universitātes Akadēmiskā bibliotēka; sast. Dagnija Ivbule; korektore Gita Bērziņa; maketu veidojusi Baiba Lazdiņa.
Ivbule, Dagnija, LU Akadēmiskā bibliotēka   +1 more
core