Results 21 to 30 of about 354 (165)

Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications

Journal of Diabetes Research, Volume 2018, Issue 1, 2018., 2018
The prevalence of diabetes is steadily rising, and once it occurs, it can cause multiple complications with a negative impact on the whole organism. Complications of diabetes may be macrovascular: such as stroke and ischemic heart disease as well as peripheral vascular and microvascular diseases—retinopathy, nephropathy, and neuropathy.
Alina Mihaela Leustean, Manuela Ciocoiu, Anca Sava, Claudia Florida Costea, Mariana Floria, Claudia Cristina Tarniceriu, Daniela Maria Tanase, Gaetano Santulli   +7 more
wiley   +1 more source

The synthesis of N-(4-aryl-thiazol-2-yl)-N1-(4,5,6,7-tetrahydro-3H-azepin-2-yl)-hydrazine hydrobromides and the cardioprotective activity of (41-methoxyphenyl-thiazol-2-yl) derivative [PDF]

Pharmacia, 2021
A novel series of N-(4-aryl-thiazol-2-yl)-N1-(4,5,6,7-tetrahydro-3Н-azepin-2-yl)-hydrazine derivatives were synthesized by interaction of equimolar quantities of substituted α-bromacetophenones with thiosemicarbazide and characterized on the basis of ...
Sergii А. Demchenko, Yulia А. Fedchenkova, Hanna О. Yeromina, Inna V. Herashenko, Olha H. Berdnyk, Anatolii M. Demchenko   +5 more
doaj   +3 more sources

Carnitine Deficiency and Oxidative Stress Provoke Cardiotoxicity in an Ifosfamide‐Induced Fanconi Syndrome Rat Model

Oxidative Medicine and Cellular Longevity, Volume 3, Issue 4, Page 266-274, 2010., 2010
In addition to hemorrhagic cystitis, Fanconi Syndrome is a serious clinical side effect during ifosfamide (IFO) therapy. Fanconi syndrome is a generalized dysfunction of the proximal tubule which is characterized by excessive urinary excretion of glucose, phosphate, bicarbonate, amino acids and other solutes excreted by this segment of the nephron ...
Mohamed M. Sayed-Ahmed, Amal Q. Darweesh, Amal J. Fatani   +2 more
wiley   +1 more source

MELDONIUM: EFFECTIVE ACTION POINTS

Кардиоваскулярная терапия и профилактика, 2013
The paper is focused on hypoxia and cell ischemia as universal pathogenetic mechanisms of disease development, which can be addressed by both etiotropic and pathogenetic therapy. The latter is represented by the so-called metabolic correctors. At present,
A. L. Vertkin, N. O. Khovasova, V. V. Pshenichnikova, M. A. Alekseev, A. U. Abdullaeva   +4 more
doaj   +1 more source

Meldonium (Mildronate): Primum nоn nocere

Pharmacological Research, 2016
[No abstract available]
openaire   +4 more sources

NEW PATHOGENETIC FACTORS OF ATHEROSCLEROSIS DEVELOPMENT AND POTENTIAL THERAPEUTIC APPROACHES

Кардиоваскулярная терапия и профилактика, 2013
It has been demonstrated that one of the factors in the pathogenesis of atherosclerosis, with the subsequent development of myocardial infarction (MI), stroke (S), or sudden death (SD), is trimethylaminoxide (TMAO), the end-product of dietary choline ...
I. Ya. Kalvinsh
doaj   +1 more source

Profiling Inhibitor Scaffolds for the Cancer Target Jumonji‐C Domain‐Containing Protein 6

ChemMedChem, Volume 20, Issue 23, November 28, 2025.
High‐throughput mass spectrometry assays identify scaffolds for the development of inhibitors of the anticancer target Jumonji‐C domain‐containing protein 6 (JMJD6). Molecular docking studies suggest strategies for structure‐guided inhibitor optimization.
Thomas P. Corner, Eidarus Salah, Anthony Tumber, James P. Holt‐Martyn, Lennart Brewitz, Christopher J. Schofield   +5 more
wiley   +1 more source

Histidine Decapeptide‐Incorporating Lipid Nanoparticles with Low Ionizable Lipids Proportion for Efficient Small Interfering RNA Delivery

Macromolecular Bioscience, Volume 25, Issue 9, September 2025.
Following optimization of ionizable lipid proportion via cost‐efficient vortex‐mixing method, lipid nanoparticles (LNPs) with a lower ionizable lipid proportion (27.72%), termed LNP5, are fabricated with histidine decapeptide (His10) during formulation via microfluidic mixing method. His10‐incorporated LNP5 (LNP5H) exhibited a 1.6‐fold increase in gene
Yeonho Bae, Hyeondo Lee, Jun Hyuk Lee, Sangho Yeo, Hyejung Mok   +4 more
wiley   +1 more source

Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat

ChemMedChem, Volume 19, Issue 24, December 16, 2024.
Inhibitors of the 2‐oxoglutarate (2OG)‐dependent hypoxia‐inducible factor prolyl hydroxylases (PHDs) are used for anemia treatment. Structures of the clinical PHD inhibitors Desidustat and Enarodustat complexed with the 2OG oxygenase factor inhibiting hypoxia‐inducible factor‐α (FIH) provide a basis to guide future PHD/2OG oxygenase inhibitor ...
Thomas P. Corner, Eidarus Salah, Anthony Tumber, Samanpreet Kaur, Yu Nakashima, Mark D. Allen, Lara I. Schnaubelt, Giorgia Fiorini, Lennart Brewitz, Christopher J. Schofield   +9 more
wiley   +1 more source

Mildronate effectiveness in post-hospital rehabilitation of patients with myocardial infarction

Кардиоваскулярная терапия и профилактика, 2012
Aim. To study the effects of mildronate, as a component of complex therapy, on left ventricular (LV) systolic and diastolic function and exercise capacity (EC) in myocardial infarction (MI) patients undergoing post-hospital rehabilitation.
V. P. Mikhin, O. N. Koltsova
doaj   +1 more source