Results 11 to 20 of about 961 (200)
Changes in the respiratory function of the heart and brain mitochondria of animals after chronic alcohol intoxication affected by a new GABA derivative [PDF]
Research Results in Pharmacology, 2021 Introduction: Chronic ethanol consumption leads to significant functional and structural changes in the mitochondria of the heart and brain, increasing generation of reactive oxygen species.
Tamara A. Popova +9 more
doaj +6 more sources
Altered Blood Molecular Markers of Cardiovascular Function in Rats after Intrauterine Hypoxia and Drug Therapy. [PDF]
Curr Issues Mol Biol, 2023 Many children and adults who have suffered prenatal hypoxia at an early age develop many serious diseases. This disease is an actual problem of pediatric cardiology and little studied.
Popazova O +4 more
europepmc +3 more sources
Mildronate and its Neuroregulatory Mechanisms: Targeting the Mitochondria, Neuroinflammation, and Protein Expression [PDF]
Medicina, 2013 This review for the first time summarizes the data obtained in the neuropharmacological studies of mildronate, a drug previously known as a cardioprotective agent. In different animal models of neurotoxicity and neurodegenerative diseases, we demonstrated its neuroprotecting activity. By the use of immunohistochemical methods and Western blot analysis,
Vija, Klusa +7 more
openaire +4 more sources
Cardioprotective Activity of Pharmacological Agents Affecting NO Production and Bioavailability in the Early Postnatal Period after Intrauterine Hypoxia in Rats. [PDF]
Biomedicines, 2023 Intrauterine hypoxia in newborns leads to a multifaceted array of alterations that exert a detrimental impact on the cardiovascular system. The aim of this research was to assess the cardioprotective effects of modulators of the nitric oxide (NO) system,
Popazova O +5 more
europepmc +3 more sources
Use of Meldonium in the Treatment of Patients with Coronary Artery Disease and Concomitant Arterial Hypertension [PDF]
, 2019 Coronary artery disease (CAD) remains one of the leading causes of mortality and disability in Ukraine. Arterial hypertension (AH) is one of the most common diseases and a leading risk factor for coronary artery disease.The aim of the work is to evaluate
Vakaliuk, I. (Ihor) +1 more
core +7 more sources
Gut and obesity/metabolic disease: Focus on microbiota metabolites
MedComm, Volume 3, Issue 3, September 2022., 2022 The beneficial and negative metabolites produced by gut microbiota. The gut microbiota produces all kinds of beneficial or negative metabolites and directly affects the intestinal barrier and gut hormone (GLP‐1 and PYY) release. After entering circulation, those metabolites regulate satiety, insulin release, adipose tissue function, and systemic ...
Ke Lin, Lixin Zhu, Li Yang
wiley +1 more source
NMR in Biomedicine, Volume 34, Issue 4, April 2021., 2021 Glucose metabolism is decreased in the diabetic heart. Meldonium may provide a route to counteract this by reducing L‐carnitine levels and decreasing the uptake of fatty acids into the mitochondria, resulting in improved cardiac glucose utilization. Hyperpolarized magnetic resonance has revealed that meldonium treatment elevated pyruvate dehydrogenase ...
Dragana Savic +7 more
wiley +1 more source
Рациональная фармакотерапия в кардиологии, 2015 Aim. To estimate an effect of metabolic corrector mildronate on cardiac hemodynamics and endothelium function in patients with ischemic heart disease (IHD) and heart failure (HF)Material and methods.
I. V. Sergienko +4 more
doaj +3 more sources
Mildronate. Chronic fatigue syndrome
Medical alphabet, 2020 Chronic fatigue syndrome (CFS) is a state of constant, impairing quality of life, fatigue, lasting more than 6 months, inexplicable by any of coexisting patient’s pathological conditions. The prevalence of CFS in the world is approximately 2 % of the population (120–140 mln inhabitants of Earth). The etiology of CFS is unknown.
A. V. Filippova +3 more
openaire +2 more sources
ChemMedChem, Volume 15, Issue 13, Page 1139-1149, July 3, 2020., 2020 Sights on a new target: A concise synthesis of C‐3‐substituted pyridine‐2,4‐dicarboxylic acid (2,4‐PDCA) derivatives is reported. The derivatives are potent inhibitors of the human 2‐oxoglutarate‐dependent oxygenase aspartate/asparagine‐β‐hydroxylase (AspH), which is a potential medicinal chemistry target for cancer therapy.
Lennart Brewitz +5 more
wiley +1 more source